Synthesis of novel N-(4-benzoylphenyl)-2-furamide derivatives and their pharmacological evaluation as potent antihyperlipidemic agents in rats [0.03%]
新型N-(4-苯甲酰基苯基)-2-呋喃甲胺衍生物的合成及其降血脂药理活性评价
T Al-Qirim,G Shattat,G A Sheikha et al.
T Al-Qirim et al.
In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis and pharmacological activity of a series of novel N-(4-benzoylphenyl)-2-furamides (3a-3e). Hyperlipidemia was induced in rats by single in...
Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases [0.03%]
单萜化合物端紫苏酮的抗炎特性：在炎症性气道疾病联合治疗中的现有证据
U R Juergens
U R Juergens
1,8-cineole is a natural monoterpene, also known as eucalyptol. It is a major compound of many plant essential oils, mainly extracted from Eucalyptus globulus oil. As an isolated compound, 1,8-cineole is known for its mucolytic and spasmoly...
Expression of HPV-16 E6 protein and p53 inactivation increases the uterine cervical cancer invasion [0.03%]
HPV-16 E6蛋白表达及P53失活增强子宫颈癌侵袭性
X Yang,L Lu
X Yang
Introduction: Human papillomavirus infection (HPV-16) and expression of HPV E6 protein are the major risk factors of cervical cancer. Studies reported that expression of E6 protein adversely affect the function of p53 and...
Luteolin induces apoptosis, G0/G1 cell cycle growth arrest and mitochondrial membrane potential loss in neuroblastoma brain tumor cells [0.03%]
黄酮类化合物山柰酚诱导神经母细胞瘤脑肿瘤细胞凋亡、G0/G1期生长阻滞和线粒体膜电位丧失
F Wang,F Gao,S Pan et al.
F Wang et al.
The objective of the present research work was to evaluate the anticancer properties of luteolin against SH-SY5Y neuroblastoma tumor cell line. Cell viability was evaluated by MTT assay after luteolin treatment. Lactate dehydrogenase assay ...
Synthesis and characterization of centhaquin and its citrate salt and a comparative evaluation of their cardiovascular actions [0.03%]
羟基环己二烯-imine(_centhaquin)_及其柠檬酸盐的合成，表征及心血管活性比较研究
M S J Reniguntala,M S Lavhale,S V Andurkar et al.
M S J Reniguntala et al.
Centhaquin is a compound that produces hypotension and bradycardia in higher doses and resuscitation in lower doses. It is water insoluble, and is unsuitable for intravenous use. We prepared the citrate salt of centhaquin and evaluated its ...
Comparative Study
Drug research. 2015 Apr;65(4):184-91. DOI:10.1055/s-0034-1375629 2015
Chronopharmacology of analgesic effect and tolerance induced by six narcotic analgesics in mice [0.03%]
六种麻醉止痛剂的小鼠止痛效果和耐受性的时辰药理学研究
Z-q Yu,C-l Zhang,Y-j Xu et al.
Z-q Yu et al.
Narcotic analgesics, especially morphine, exert significantly different effects depending on the time within one day. The objective of this study was to observe whether the dosing time of 6 narcotic analgesics in mice affected their efficac...
Effect of Chronic Administration of Buspirone and Fluoxetine on Inflammatory Cytokines in 6-Hydroxydopamine-lesioned Rats [0.03%]
长效布斯吡龙和氟西丁对6-羟基多巴胺损伤大鼠炎症细胞因子的影响
H Sharifi,A M Nayebi,S Farajnia et al.
H Sharifi et al.
Neuro-inflammation in Parkinson's disease (PD) is associated with glial cell activation and production of different inflammatory cytokines. In this study we investigated the effect of chronic administration of buspirone and fluoxetine on ce...
Efficacy and Safety of Sufentanil and Pethidine in Spinal Anesthesia for Painless Labor [0.03%]
硫酸舒芬太尼与哌替啶用于无痛分娩腰麻镇痛效果及安全性分析
S Salarian,M Fathi,B Farzanegan et al.
S Salarian et al.
Saddle spinal is a reliable method for control of pain during labor. This method has rapid onset and causes complete sensory block without significant influence on motor neurons.Our goal was to compare the analgesic efficacy and side effect...
Randomized Controlled Trial
Drug research. 2015 Jul;65(7):344-6. DOI:10.1055/s-0034-1372610 2015
A simple HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat liver tissue [0.03%]
一种简单的心脏组织和血浆中阿卡波糖的固相萃取-阳离子交换反向色谱法测定方法
Y Liu,C Shao,B Fan et al.
Y Liu et al.
A simple HPLC method to determine the amount of 10-methoxycamptothecin (MCPT) and its major metabolite 10-hydroxycamptothecin (HCPT) in rat liver tissue was developed in the present study. Camptothecin (CPT) was used as internal standard (I...
Validation and method development of Tadalafil in bulk and tablet dosage form by RP-HPLC [0.03%]
原料药和片剂制剂中西地那非的RP-HPLC验证及方法学研究
A Bojanapu,A T Subramaniam,J Munusamy et al.
A Bojanapu et al.
A novel, precise, rapid and sensitive reverse phase high performance liquid chromatographic method has been developed for the validated estimation of Tadalafil in bulk and tablet dosage form. The separation was achieved on Agilent Eclipse X...