Protective Effects of Xanthine Derivatives Against Arsenic Trioxide-Induced Oxidative Stress in Mouse Hepatic and Renal Tissues [0.03%]
甲羟基衍生物对三氧化二砷诱导的小鼠肝肾组织氧化应激的保护作用
Navid Omidifar,Ahmad Gholami,Mansoureh Shokripour et al.
Navid Omidifar et al.
In this study, the protective efficacy of pentoxifylline (PTX) as a xanthine derivative against arsenic trioxide (ATO)-induced kidney and liver damage in mice was investigated. Thirty-six mice were divided into six groups, receiving intrape...
In-silico, Synthesis, Characterization, and In-vitro Studies on Benzylidene-based 2-chloroquinolin Derivatives as Free Radical Scavengers in Parkinson's Disease [0.03%]
基于苯甲酰亚胺的2-氯喹啉衍生物作为清除帕金森病中自由基的物质的计算机模拟，合成，表征及体外研究
Gomathy Subramanian,Kaveri Prasad,Jagdish Chand et al.
Gomathy Subramanian et al.
Parkinson's disease is the loss of dopaminergic neurons in the substantial nigra part of the brain leading to neurodegeneration. Whereas, reactive oxygen species and mitochondrial impairment are considered to be the major pathophysiology of...
Effects of SGLT2 Inhibitors and DPP-4 Inhibitors on Advanced Glycation End Products [0.03%]
SGLT2抑制剂和DPP-4抑制剂对晚期甘#endregion
Masataka Kusunoki,Fumiya Hisano,Shin-Ichi Matsuda et al.
Masataka Kusunoki et al.
Clinical trials have revealed that sodium glucose cotransporter 2 (SGLT2) inhibitors suppress the onset of heart failure and cardiovascular death in diabetic patients. On the other hand, few reports have been published concerning such effec...
Design, Synthesis and In Vitro Evaluation of Levodopa Stearic Acid Hydrazide Conjugate for the Management of Parkinson's DiseaseNovel Conjugate for Parkinson's Disease [0.03%]
左旋多巴硬脂酸肼偶联物的设计、合成及体外评估在帕金森病治疗中的应用新型偶联物用于治疗帕金森病
Vasanthi Chinraj,Ramakkamma Aishwarya Reddy,Jubie Selvaraj et al.
Vasanthi Chinraj et al.
Parkinson's disease is the highest prevalent neurodegenerative disease in elderly individuals after Alzheimer's disease. The pathological identification for Parkinson's disease is loss of dopaminergic neurons in substantia nigra region of t...
Therapeutic Effects of Tamsulosin in Nightmare Disorder: A Randomized, Double Blind, Placebo-Controlled, Cross-Over, Pilot Study [0.03%]
坦索罗辛对噩梦障碍的治疗作用：一项随机、双盲、安慰剂对照、交叉、试点研究
Negin Naderifar,Elnaz Roohi,Ali Sharifi et al.
Negin Naderifar et al.
Nightmare disorder is associated with functional impairment, distress, and low quality of life; however, studies on pharmacotherapy of this debilitating disorder yielded mixed results. Prazosin, a non-selective α1 blocker is reported to be...
Randomized Controlled Trial
Drug research. 2024 Feb;74(2):53-59. DOI:10.1055/a-2226-3604 2024
Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model [0.03%]
使用缺血/再灌注损伤模型研究香豆素衍生物在心力衰竭中的生物活性
Lauro Figueroa-Valverde,Marcela Rosas-Nexticapa,Magdalena Alvarez-Ramirez et al.
Lauro Figueroa-Valverde et al.
Heart failure is a health problem worldwide. There are some drugs for it, including digoxin, spironolactone, captopril, and valsartan, but some of these drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia, hyponatre...
Correction: Structure-Based Drug Design for Targeting IRE1: An in Silico Approach for Treatment of Cancer [0.03%]
纠正：基于结构的药物设计以IRE1作为靶点：一种癌症治疗的计算机模拟方法
Alireza Poustforoosh,Sanaz Faramarz,Mohammad Hadi Nematollahi et al.
Alireza Poustforoosh et al.
Published Erratum
Drug research. 2024 Feb;74(2):e1. DOI:10.1055/a-2235-8845 2024
"In-silico Design and Development of Novel Hydroxyurea Lipid Drug Conjugates for Breast Cancer Therapy Targeting PI3K/AKT/mTOR Pathway" [0.03%]
"针对PI3K/AKT/mTOR通路的乳腺癌治疗设计和开发新型羟基脲脂质药物 conjugates"
注意：在专业领域中，某些术语可能保持不变或使用其广泛接受的缩写形式，以确保准确性和一致性。例如，“Hydroxyurea Lipid Drug Conjugates”翻译为“羟基脲脂质药物共轭体”，但有时为了简洁和精确，可能会直接保留"Conjugates"一词或使用其对应的缩写。因此，更常见的表达可能是：“针对PI3K/AKT/mTOR通路的乳腺癌治疗设计和开发新型羟基脲脂质药物共轭体”。
Saranya Dharmaraj,Akey Krishna Swaroop,Mariappan Esakkimuthukumar et al.
Saranya Dharmaraj et al.
Hydroxyurea (HU) has shown promise in breast cancer treatment, but its hydrophilic nature limits its efficacy. Therefore, conjugating HU with lipids could increase its liphophilicity and improve its cellular uptake, leading to increased eff...
Quality by Design in Pharmaceuticals: A Review of its Impact on Regulatory Compliance and Product Quality [0.03%]
制药行业中的设计质量：对其对法规符合性和产品质量影响的综述
Raja Shekhar Nunavath,Madhu Tanya Singh,Anubha Jain et al.
Raja Shekhar Nunavath et al.
The pharmaceutical industry has embraced the quality-by-design (QbD) approach as a promising development, formulation and manufacturing strategy. QbD provides a systematic and science-based framework for designing and producing high-quality...
Structure-Based Drug Design for Targeting IRE1: An in Silico Approach for Treatment of Cancer [0.03%]
基于结构的药物设计针对IRE1的抗癌虚拟筛选方法
Alireza Poustforoosh,Sanaz Faramarz,Mohammad Hadi Nematollahi et al.
Alireza Poustforoosh et al.
Background: Endoplasmic Reticulum (ER) stress and Unfolded Protein Response (UPR) play a key role in cancer progression. The aggregation of incorrectly folded proteins in the ER generates ER stress, which in turn activate...