B cell academy of the gut: an update on gut associated germinal centre B cell dynamics [0.03%]
肠道B细胞学院：关于肠道相关生发中心B细胞动态的最新研究
Christopher Wichmann,Elisa Wirthgen,Carla R Nowosad et al.
Christopher Wichmann et al.
Background: The gut is an environment in which the immune system closely interacts with a vast number of foreign antigens, both inert such as food and alive, from the viral, bacterial, fungal and protozoal microbiota. Wit...
Effects of multistrain Bifidobacteria and Lactobacillus probiotics on HMO compositions after supplementation to pregnant women at threatening preterm delivery: design of the randomized clinical PROMO trial [0.03%]
多菌株益生菌对妊娠期有早产风险的孕妇乳汁低聚糖的影响：PROMO试验的设计
A Welp,E Laser,K Seeger et al.
A Welp et al.
Background: As an indigestible component of human breast milk, Human Milk Oligosaccharides (HMOs) play an important role as a substrate for the establishing microbiome of the newborn. They have further been shown to have ...
Immune-mediated inflammatory diseases (IMIDs) in children: key research questions and some answers [0.03%]
儿童免疫介导性炎症性疾病（IMIDs）：关键研究问题及部分答案
Tilmann Kallinich,Marcus A Mall
Tilmann Kallinich
Changes in vitamins and trace elements after initiation of highly effective CFTR modulator therapy in children and adults with cystic fibrosis - a real-life insight [0.03%]
高效CFTR调控药物治疗对囊性纤维化患儿及成人维生素和微量元素水平的影响——基于真实世界研究的见解
Dorit Fabricius,Tina Knieling,Noelle Zurmuehl et al.
Dorit Fabricius et al.
Background: Highly-effective CFTR-modulator therapy with elexa-/teza-/ivacaftor (ETI) has led to improvements in pulmonary outcomes, sweat chloride, body mass index (BMI) and quality of life in people with cystic fibrosis...
Tipping the balance in autoimmunity: are regulatory t cells the cause, the cure, or both? [0.03%]
调控性T细胞在自身免疫中的平衡作用：是病因、治疗手段还是两者兼有？
Matthias Hardtke-Wolenski,Sybille Landwehr-Kenzel
Matthias Hardtke-Wolenski
Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation route, Tregs can be subdivided into...
Adverse effects of remdesivir for the treatment of acute COVID-19 in the pediatric population: a retrospective observational study [0.03%]
瑞德西韦治疗儿童急性COVID-19的不良反应：一项回顾性观察研究
Abigail Schulz,Natalie Huynh,Margaret Heger et al.
Abigail Schulz et al.
Background: Although the severity of coronavirus disease 2019 (COVID-19) tends to be lower in children, it can still lead to severe illness, particularly among those with chronic medical conditions. While remdesivir (RDV)...
The role of regulatory B cells in immune regulation and childhood allergic asthma [0.03%]
调节性B细胞在免疫调节和儿童过敏性哮喘中的作用
Caroline Vanessa Kliem,Bianca Schaub
Caroline Vanessa Kliem
Background: As the most common chronic disease in childhood, asthma displays a major public health problem worldwide with the incidence of those affected rising. As there is currently no cure for allergic asthma, it is ma...
Phagocytic cell death leads to enhanced release of pro-inflammatory S100A12 in familial Mediterranean fever [0.03%]
吞噬细胞死亡导致遗传性地中海发热患者促炎症S100A12释放增加
G Varga,S Schleifenbaum,U Koenig et al.
G Varga et al.
Background: Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been sho...
Installation of the developing nephron in the fetal human kidney during advanced pregnancy [0.03%]
妊娠晚期人肾发育小管的形成与发展
Will W Minuth
Will W Minuth
Background: The kidneys of preterm and low birth weight babies reflect vulnerability, since several noxae can evoke the termination of nephron formation. This again leads to oligonephropathy with severe consequences for h...
Gene therapy-based strategies for spinal muscular atrophy-an Asia-Pacific perspective [0.03%]
基于基因治疗的脊髓性肌萎缩症策略——亚太地区视角
Michelle A Farrar,Loudella Calotes-Castillo,Ranil De Silva et al.
Michelle A Farrar et al.
Onasemnogene abeparvovec has been life-changing for children with spinal muscular atrophy (SMA), signifying the potential and progress occurring in gene- and cell-based therapies for rare genetic diseases. Hence, it is important that clinic...