Next-generation sequencing of cell-free microbial DNA in blood samples of critically ill children: a single-center experience [0.03%]
儿童重症监护病房患者血液中游离微生物DNA的高通量测序分析
Jonas E Adolph,Christina Pentek,Thomas Bauch et al.
Jonas E Adolph et al.
Background: Rapid and accurate pathogen detection is critical for optimizing outcomes in pediatric sepsis. Next-generation sequencing (NGS) of cell-free DNA (cfDNA) from blood enables culture-independent identification of...
Excessive poly(ADP)-ribosylation in the inflamed mucosa of pediatric celiac disease points to a novel inflammatory mechanism and therapeutic target [0.03%]
儿童乳糜泻炎症黏膜中过度的聚（腺苷二磷酸）核糖基化指出了一个新型的炎性机制和治疗靶点
Tala M Haddadin,Tarek M Masannat,Irshad A Sheikh et al.
Tala M Haddadin et al.
Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten exposure in genetically susceptible individuals, characterized by chronic intestinal inflammation, epithelial damage, and immune dysreg...
Time-resolved urinary proteomics reveals heme-associated oxidative stress responses in neonatal hypoxic-ischaemic encephalopathy [0.03%]
基于时间的尿蛋白组学研究揭示了新生儿缺氧缺血性脑病中的血红素相关氧化应激反应
Magdalena Zasada,Maciej Suski,Marta Olszewska et al.
Magdalena Zasada et al.
Background: Neonatal hypoxic-ischemic encephalopathy (HIE) triggers systemic oxidative stress and redox imbalance, contributing to multi-organ injury. Urine is a noninvasive matrix for longitudinal profiling of molecular ...
Savina Abraham-Pol,Ertan Mayatepek,Mark Dzietko
Savina Abraham-Pol
Perinatal brain injury remains a major cause of neonatal morbidity and lifelong neurological disability. Despite advances in neonatal care, the molecular determinants that modulate vulnerability and recovery in the immature brain remain poo...
Soluble mucosal addressin cell adhesion molecule 1 is a biomarker for pediatric ulcerative colitis [0.03%]
可溶性黏膜地址素细胞粘附分子1是儿童溃疡性结肠炎的生物标志物
Moritz Muschaweck,Christian Gutbier,Gernot Sellge et al.
Moritz Muschaweck et al.
Background: Enhanced expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) on high endothelial venules facilitates lymphocyte migration to sites of intestinal inflammation in inflammatory bowel disease (IBD)...
miR223, miR30e, and miR30a show associations with perinatal metabolic acidosis in neonates with hypoxic-ischemic encephalopathy [0.03%]
miR223、miR30e和miR30a与缺氧缺血性脑病新生儿围生期代谢性酸中毒的关系研究
Rohan Mahesh Patil,Matteo Miele,Maurizio Giordano et al.
Rohan Mahesh Patil et al.
Objective: Hypoxic-Ischemic Encephalopathy (HIE) is a leading cause of neonatal death and long-term disabilities, leading researchers to explore novel candidate biomarkers to improve early diagnosis and guide treatment st...
Untargeted metabolomics profiling of childhood asthma: linking metabolic pattern to disease severity [0.03%]
儿童哮喘未目标代谢组学谱分析：将代谢模式与疾病严重程度相联系
Shereen M Aleidi,Yousra A Hagyousif,Basma Majed Sharaf et al.
Shereen M Aleidi et al.
Background: Asthma is a heterogeneous inflammatory airway disorder associated with complex metabolic alterations. Despite significant advances in diagnosis and treatment, its prevalence and disease burden continue to rise...
O-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma [0.03%]
O-GlcNAcylation表达通过抑制MYCN来预测神经母细胞瘤的良好预后并缓解恶性表型
Neng-Yu Lin,Hsiu-Hao Chang,Chia-Yeh Hsieh et al.
Neng-Yu Lin et al.
Background: Neuroblastoma (NB) is a common pediatric malignancy originating from neural crest progenitor cells. While O-GlcNAcylation is known to regulate cancer cell metabolism and behavior, its specific role and prognos...
Longitudinal functional lung imaging in children with Post-COVID-19 syndrome [0.03%]
患有新冠后遗症的儿童的功能性肺部影像学纵向研究
Calvin Kraus,Lina Tan,Maximilian Hinsen et al.
Calvin Kraus et al.
Background: Respiratory distress and COVID-19-related symptoms persist as Post-COVID-19 syndrome (PCS) in a proportion of children and adolescents. We aimed to determine whether ventilation or perfusi...
Antioxidants rescue murine mesangial cells from docosahexaenoic acid-induced ferroptosis [0.03%]
抗氧化剂可救治系列乙酸诱导的鼠系肌成纤维细胞铁死亡
Leon Saschin,Anna Kowalewski,Gregor Fink et al.
Leon Saschin et al.
Background: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with anti-inflammatory effects. However, few studies have investigated their molecular effects in the kidney. We have previously shown that intrau...