Savina Abraham-Pol,Ertan Mayatepek,Mark Dzietko
Savina Abraham-Pol
Perinatal brain injury remains a major cause of neonatal morbidity and lifelong neurological disability. Despite advances in neonatal care, the molecular determinants that modulate vulnerability and recovery in the immature brain remain poo...
Soluble mucosal addressin cell adhesion molecule 1 is a biomarker for pediatric ulcerative colitis [0.03%]
可溶性黏膜地址素细胞粘附分子1是儿童溃疡性结肠炎的生物标志物
Moritz Muschaweck,Christian Gutbier,Gernot Sellge et al.
Moritz Muschaweck et al.
Background: Enhanced expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) on high endothelial venules facilitates lymphocyte migration to sites of intestinal inflammation in inflammatory bowel disease (IBD)...
miR223, miR30e, and miR30a show associations with perinatal metabolic acidosis in neonates with hypoxic-ischemic encephalopathy [0.03%]
miR223、miR30e和miR30a与缺氧缺血性脑病新生儿围生期代谢性酸中毒的关系研究
Rohan Mahesh Patil,Matteo Miele,Maurizio Giordano et al.
Rohan Mahesh Patil et al.
Objective: Hypoxic-Ischemic Encephalopathy (HIE) is a leading cause of neonatal death and long-term disabilities, leading researchers to explore novel candidate biomarkers to improve early diagnosis and guide treatment st...
Untargeted metabolomics profiling of childhood asthma: linking metabolic pattern to disease severity [0.03%]
儿童哮喘未目标代谢组学谱分析：将代谢模式与疾病严重程度相联系
Shereen M Aleidi,Yousra A Hagyousif,Basma Majed Sharaf et al.
Shereen M Aleidi et al.
Background: Asthma is a heterogeneous inflammatory airway disorder associated with complex metabolic alterations. Despite significant advances in diagnosis and treatment, its prevalence and disease burden continue to rise...
O-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma [0.03%]
O-GlcNAcylation表达通过抑制MYCN来预测神经母细胞瘤的良好预后并缓解恶性表型
Neng-Yu Lin,Hsiu-Hao Chang,Chia-Yeh Hsieh et al.
Neng-Yu Lin et al.
Background: Neuroblastoma (NB) is a common pediatric malignancy originating from neural crest progenitor cells. While O-GlcNAcylation is known to regulate cancer cell metabolism and behavior, its specific role and prognos...
Longitudinal functional lung imaging in children with Post-COVID-19 syndrome [0.03%]
患有新冠后遗症的儿童的功能性肺部影像学纵向研究
Calvin Kraus,Lina Tan,Maximilian Hinsen et al.
Calvin Kraus et al.
Background: Respiratory distress and COVID-19-related symptoms persist as Post-COVID-19 syndrome (PCS) in a proportion of children and adolescents. We aimed to determine whether ventilation or perfusi...
Antioxidants rescue murine mesangial cells from docosahexaenoic acid-induced ferroptosis [0.03%]
抗氧化剂可救治系列乙酸诱导的鼠系肌成纤维细胞铁死亡
Leon Saschin,Anna Kowalewski,Gregor Fink et al.
Leon Saschin et al.
Background: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with anti-inflammatory effects. However, few studies have investigated their molecular effects in the kidney. We have previously shown that intrau...
Monogenic obesity due to MC4R deficiency: lessons from a multigenerational case [0.03%]
MC4R缺陷引起的单基因型肥胖症：一个多代家庭的启示
Eleni Z Giannopoulou,Stefanie Zorn,Melanie Schirmer et al.
Eleni Z Giannopoulou et al.
Background: Melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity, yet remains underdiagnosed. Patients with monogenic obesity often undergo a frustrating diagnostic and therapeutic odyss...
Claudia U Duerr,Marcus A Mall
Claudia U Duerr
ILC2s are innate lymphoid cells that become activated by alarmins and are major producers of type 2 signature cytokines. In mice and human, ILC2s have been identified and characterized in several pre-clinical disease models and patients wit...
Pazopanib as maintenance therapy in pediatric ewing sarcoma: a case series of six patients [0.03%]
帕唑帕尼作为六例儿童尤因肉瘤维持治疗的疗效观察报告
Nihan Bayram,Murat Elli,Yontem Yaman et al.
Nihan Bayram et al.
Introduction: Ewing sarcoma (ES) is an aggressive pediatric bone and soft tissue malignancy. Despite advances in multimodal therapy, outcomes remain suboptimal for patients with high-risk features such as large tumor volu...