GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn's disease [0.03%]
GM-CSF与髓系调节细胞在克罗恩病发病机制及治疗中的作用
Jan Däbritz
Jan Däbritz
Background: Intestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-st...
Modified mRNA as a new therapeutic option for pediatric respiratory diseases and hemoglobinopathies [0.03%]
改良型mRNA作为儿科呼吸系统疾病和血红蛋白病的新治疗选择
Justin S Antony,Alexander Dewerth,Ashiqul Haque et al.
Justin S Antony et al.
Background: The immunogenicity and limited stability of conventional messenger RNA (mRNA) has traditionally restricted its potential therapeutic use. In 1992, the first clinical application of mRNA was reported as a poten...
Silke Meiners,Korbinian Ballweg
Silke Meiners
Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pathway or the lysosome-autophagy ...
Mike-Andrew Westhoff,Oliver Brühl,Klaus-Michael Debatin
Mike-Andrew Westhoff
Background: Most cancer therapies are devised for adult or even elder patients. However, when dealing with pediatric cancers, additional considerations are needed. ...
Fanconi anemia: young patients at high risk for squamous cell carcinoma [0.03%]
范可尼贫血症：年轻患者患鳞状细胞癌的风险较高
Eunike Velleuer,Ralf Dietrich
Eunike Velleuer
Background: Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, i...
Bianca Ueberberg,Malte Kohns,Ertan Mayatepek et al.
Bianca Ueberberg et al.
Background: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diag...
Katharina Rose Luise Schmitt,Giang Tong,Felix Berger
Katharina Rose Luise Schmitt
Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the p...
Chrysanthy Ikonomidou
Chrysanthy Ikonomidou
Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate cell death, aberrant network rewi...
Renal response to short- and long-term exercise in very-long-chain acyl-CoA dehydrogenase-deficient (VLCAD(-/-)) mice [0.03%]
短期和长期运动对极长链酰基辅酶a脱氢酶缺陷小鼠肾脏的反应
Sara Tucci,Antonia Krogmann,Diran Herebian et al.
Sara Tucci et al.
Background: Deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD) is the most common disorder of mitochondrial β-oxidation of long-chain fatty acids. In order to maintain glucose homeostasis, the kidney and liver ...
Klaus-Michael Debatin
Klaus-Michael Debatin