Mike-Andrew Westhoff,Oliver Brühl,Klaus-Michael Debatin
Mike-Andrew Westhoff
Background: Most cancer therapies are devised for adult or even elder patients. However, when dealing with pediatric cancers, additional considerations are needed. ...
Fanconi anemia: young patients at high risk for squamous cell carcinoma [0.03%]
范可尼贫血症：年轻患者患鳞状细胞癌的风险较高
Eunike Velleuer,Ralf Dietrich
Eunike Velleuer
Background: Fanconi anemia is one of the best studied inherited cancer-prone diseases. Greatly improved protocols for hematopoietic stem cell transplantation increasingly save the lives of these young patients. However, i...
Bianca Ueberberg,Malte Kohns,Ertan Mayatepek et al.
Bianca Ueberberg et al.
Background: MicroRNAs (miRNAs) are crucial regulators of human immunity e.g. against Mycobacterium tuberculosis. Against the background of still alarming high mortality of tuberculosis effective biomarkers to improve diag...
Katharina Rose Luise Schmitt,Giang Tong,Felix Berger
Katharina Rose Luise Schmitt
Therapeutic hypothermia is an effective cytoprotectant and promising intervention shown to improve outcome in patients following cardiac arrest and neonatal hypoxia-ischemia. However, despite our clinical and experimental experiences, the p...
Chrysanthy Ikonomidou
Chrysanthy Ikonomidou
Matrix metalloproteinases are vital drivers of synaptic remodeling in health and disease. It is suggested that at early stages of epileptogenesis, inhibition of matrix metalloproteinases may help ameliorate cell death, aberrant network rewi...
Renal response to short- and long-term exercise in very-long-chain acyl-CoA dehydrogenase-deficient (VLCAD(-/-)) mice [0.03%]
短期和长期运动对极长链酰基辅酶a脱氢酶缺陷小鼠肾脏的反应
Sara Tucci,Antonia Krogmann,Diran Herebian et al.
Sara Tucci et al.
Background: Deficiency of very long-chain acyl-CoA dehydrogenase (VLCAD) is the most common disorder of mitochondrial β-oxidation of long-chain fatty acids. In order to maintain glucose homeostasis, the kidney and liver ...
Klaus-Michael Debatin
Klaus-Michael Debatin
Monogenic forms of childhood obesity due to mutations in the leptin gene [0.03%]
由于瘦素基因突变导致的儿童肥胖单基因病形式
Jan-Bernd Funcke,Julia von Schnurbein,Belinda Lennerz et al.
Jan-Bernd Funcke et al.
Congenital leptin deficiency is a rare autosomal recessive monogenic obesity syndrome caused by mutations in the leptin gene. This review describes the molecular and cellular characteristics of the eight distinct mutations found so far in h...
Jörg Dötsch
Jörg Dötsch
Background and findings: Perinatal programming, i.e., the (epigenetic) modification of (genetic) functions throughout lifetime, suffers from the notion of premature theories and difficult and extensive research strategies...
Cara J Westmark
Cara J Westmark
Background: Fragile X is the most common form of inherited intellectual disability and the leading known genetic cause of autism. There is currently no cure or approved medication for fragile X although various drugs targ...