Georg F Vogel,Michael W Hess,Kristian Pfaller et al.
Georg F Vogel et al.
Microvillus inclusion disease (MVID) is characterised by onset of intractable life-threatening watery diarrhoea during infancy. Transmission electron microscopy demonstrates shortening or absence of apical microvilli, pathognomonic microvil...
Birthe Gericke,Mahdi Amiri,Hassan Y Naim
Birthe Gericke
Osmotic diarrhea and abdominal pain in humans are oftentimes associated with carbohydrate malabsorption in the small intestine due to loss of function of microvillar disaccharidases. Disaccharidases are crucial for the digestion and the sub...
Yatrik M Shah
Yatrik M Shah
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestine. IBD is a multifactorial disorder, and IBD-associated genes are critical in innate immune response, inflammatory response, autophagy, and epitheli...
Expression and function of histamine and its receptors in atopic dermatitis [0.03%]
组胺及其受体在特应性皮炎的表达及功能研究进展
M Albrecht,A M Dittrich
M Albrecht
Background: Atopic dermatitis constitutes a most burdensome chronic inflammatory skin disease. Standard treatment is cumbersome and often targets its main symptom, pruritus, only insufficiently. ...
Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis? [0.03%]
多能干细胞在疾病建模和药物筛选中的作用：能否为囊性纤维化治疗带来新视角？
Ulrich Martin
Ulrich Martin
Despite continuous improvements in treating clinical symptoms and the identification of single compounds that effectively rescue some rare mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), associated lung and live...
Post stroke hemi-dystonia in children: a neglected area of research [0.03%]
儿童脑卒中后半侧肌张力不全：一个被忽视的研究领域
Daniel Tibussek,Ertan Mayatepek,Dirk Klee et al.
Daniel Tibussek et al.
Background: Childhood arterial ischemic stroke (CAIS) is increasingly recognized as an important cause of significant long-term morbidity in the pediatric population. Post stroke movement disorders, above all hemi-dystoni...
Jennie G Ono,Tilla S Worgall,Stefan Worgall
Jennie G Ono
Asthma is a clinically heterogeneous disorder, whose onset and progression results from a complex interplay between genetic susceptibility, allergens, and viral triggers. Sphingolipids and altered sphingolipid metabolism have emerged as pot...
GM-CSF and the role of myeloid regulatory cells in the pathogenesis and treatment of Crohn's disease [0.03%]
GM-CSF与髓系调节细胞在克罗恩病发病机制及治疗中的作用
Jan Däbritz
Jan Däbritz
Background: Intestinal monocytes/macrophages sustain the intestinal immune homeostasis and might be an attractive therapeutic target for the management of inflammatory bowel disease (IBD). Granulocyte macrophage colony-st...
Modified mRNA as a new therapeutic option for pediatric respiratory diseases and hemoglobinopathies [0.03%]
改良型mRNA作为儿科呼吸系统疾病和血红蛋白病的新治疗选择
Justin S Antony,Alexander Dewerth,Ashiqul Haque et al.
Justin S Antony et al.
Background: The immunogenicity and limited stability of conventional messenger RNA (mRNA) has traditionally restricted its potential therapeutic use. In 1992, the first clinical application of mRNA was reported as a poten...
Silke Meiners,Korbinian Ballweg
Silke Meiners
Protein homeostasis describes the tight supervision of protein synthesis, correct protein maturation and folding, as well as the timely disposal of unwanted and damaged proteins by the ubiquitin-proteasome pathway or the lysosome-autophagy ...