Robert C Fellner,Shawn T Terryah,Robert Tarran
Robert C Fellner
Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are all chronic pulmonary diseases, albeit with different etiologies, that are characterized by airflow limitation, chronic inflammation, and abnormal mucus prod...
Matthias C Hütten,Tim G A M Wolfs,Boris W Kramer
Matthias C Hütten
After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfer...
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens [0.03%]
缺氧对肠上皮细胞功能的影响及其对细菌病原菌入侵的后果
Nathalie E Zeitouni,Sucheera Chotikatum,Maren von Köckritz-Blickwede et al.
Nathalie E Zeitouni et al.
The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted by increasing local blood flow...
Manipulating proteostasis to repair the F508del-CFTR defect in cystic fibrosis [0.03%]
调控蛋白质稳态修复囊性纤维化F508del-CFTR缺陷
Speranza Esposito,Antonella Tosco,Valeria R Villella et al.
Speranza Esposito et al.
Cystic fibrosis (CF) is a lethal monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that entails the (diagnostic) increase in sweat electrolyte concentrations, progressive lung disea...
Update on host-pathogen interactions in cystic fibrosis lung disease [0.03%]
囊性纤维化肺病中宿主与病原菌相互作用的最新研究进展
Andreas Hector,Nina Frey,Dominik Hartl
Andreas Hector
Bacterial and fungal infections are hallmarks of cystic fibrosis (CF) lung disease. In the era of long-term inhaled antibiotics and increasing CF patient survival, new "emerging" pathogens are detected in CF airways, yet their pathophysiolo...
Underlying molecular and cellular mechanisms in childhood irritable bowel syndrome [0.03%]
儿童肠易激综合征的分子和细胞机制
Bruno P Chumpitazi,Robert J Shulman
Bruno P Chumpitazi
Irritable bowel syndrome (IBS) affects a large number of children throughout the world. The symptom expression of IBS is heterogeneous, and several factors which may be interrelated within the IBS biopsychosocial model play a role. These fa...
Fructose malabsorption [0.03%]
果糖不耐症
Karolin Ebert,Heiko Witt
Karolin Ebert
Incomplete intestinal absorption of fructose might lead to abdominal complaints such as pain, flatulence and diarrhoea. Whether defect fructose transporters such as GLUT5 or GLUT2 are involved in the pathogenesis of fructose malabsorption i...
Diverse roles of endoplasmic reticulum stress sensors in bacterial infection [0.03%]
内质网应激传感器在细菌感染中的多种作用
Helena Pillich,Maria Loose,Klaus-Peter Zimmer et al.
Helena Pillich et al.
Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there are graded responses collectiv...
M Vittoria Barone,K Peter Zimmer
M Vittoria Barone
Background: Celiac disease (CD) is a frequent inflammatory intestinal disease, with a genetic background, caused by gliadin-containing food. Some gliadin peptides are not digested by intestinal proteases and can have diff...
Maria Henström,Mauro D&#x;Amato
Maria Henström
Irritable bowel syndrome (IBS) is a common condition with a complex and largely unknown etiology. There is no cure, and treatment options are mainly directed to the amelioration of symptoms. IBS causes reduced quality of life and poses cons...