The need for coordination of research activities in pediatric lung diseases [0.03%]
儿童肺部疾病研究活动协调的必要性
Harald Ehrhardt,Klaus-Peter Zimmer
Harald Ehrhardt
Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease [0.03%]
中性粒细胞弹性蛋白酶和基质金属蛋白酶12在囊性纤维化肺病中的作用
Claudius J Wagner,Carsten Schultz,Marcus A Mall
Claudius J Wagner
Chronic lung disease remains the major cause of morbidity and mortality in patients with cystic fibrosis (CF). Recent studies in young children with CF diagnosed by newborn screening identified neutrophil elastase (NE), a major product rele...
Early injury of the neonatal lung contributes to premature lung aging: a hypothesis [0.03%]
新生儿肺损伤导致早产儿肺衰老假说
Silke Meiners,Anne Hilgendorff
Silke Meiners
Chronic lung disease of the newborn, also known as bronchopulmonary dysplasia (BPD), is the most common chronic lung disease in early infancy and results in an increased risk for long-lasting pulmonary impairment in the adult. BPD develops ...
Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development [0.03%]
支气管肺发育不良的发病机制：炎症与器官发育相遇的时候
Tayyab Shahzad,Sarah Radajewski,Cho-Ming Chao et al.
Tayyab Shahzad et al.
Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary function and an increased risk of ...
Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis [0.03%]
基于 Mendeliome 测序的新生儿乳酸酸中毒的病因诊断与治疗
Walid Fazeli,Mert Karakaya,Peter Herkenrath et al.
Walid Fazeli et al.
Background: Neonatal lactic acidosis can be associated to severe inborn errors of metabolism. Rapid identification of the underlying disorder may improve the clinical management through reliable counseling of the parents ...
Dieter Blaas,Renate Fuchs
Dieter Blaas
About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some...
Serena Vitale,Stefania Picascia,Carmen Gianfrani
Serena Vitale
The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells guarantee a first line of defense ...
MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality [0.03%]
微小核糖核酸与肺晚期发育及支气管肺发育不良：阐明因果关系的必要性
Claudio Nardiello,Rory E Morty
Claudio Nardiello
MicroRNA are emerging as powerful regulators of cell differentiation and tissue and organ development. Several microRNA have been described to play a role in branching morphogenesis, a key step in early lung development. However, considerab...
Mesenchymal stromal cells in the development and therapy of bronchopulmonary dysplasia [0.03%]
间充质基质细胞在支气管肺发育不良的发病机制及治疗中的作用
Marius A Möbius,Mario Rüdiger
Marius A Möbius
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, remains a major healthcare burden. Despite great progresses in perinatal medicine over the past decades, no cure for BPD has been found. The complex pathophysiology ...
Alveologenesis: key cellular players and fibroblast growth factor 10 signaling [0.03%]
肺泡发生：关键细胞成分及成纤维细胞生长因子10信号通路
Cho-Ming Chao,Alena Moiseenko,Klaus-Peter Zimmer et al.
Cho-Ming Chao et al.
Background: Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epit...