Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development [0.03%]
支气管肺发育不良的发病机制：炎症与器官发育相遇的时候
Tayyab Shahzad,Sarah Radajewski,Cho-Ming Chao et al.
Tayyab Shahzad et al.
Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary function and an increased risk of ...
Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis [0.03%]
基于 Mendeliome 测序的新生儿乳酸酸中毒的病因诊断与治疗
Walid Fazeli,Mert Karakaya,Peter Herkenrath et al.
Walid Fazeli et al.
Background: Neonatal lactic acidosis can be associated to severe inborn errors of metabolism. Rapid identification of the underlying disorder may improve the clinical management through reliable counseling of the parents ...
Dieter Blaas,Renate Fuchs
Dieter Blaas
About 150 human rhinovirus serotypes are responsible for more than 50 % of recurrent upper respiratory infections. Despite having similar 3D structures, some bind members of the low-density lipoprotein receptor family, some ICAM-1, and some...
Serena Vitale,Stefania Picascia,Carmen Gianfrani
Serena Vitale
The gut mucosa is continuously exposed to food and microbial antigens. Both enterocytes and intraepithelial lymphocytes have a pivotal role in maintaining the integrity of intestinal mucosa, as these cells guarantee a first line of defense ...
MicroRNA in late lung development and bronchopulmonary dysplasia: the need to demonstrate causality [0.03%]
微小核糖核酸与肺晚期发育及支气管肺发育不良：阐明因果关系的必要性
Claudio Nardiello,Rory E Morty
Claudio Nardiello
MicroRNA are emerging as powerful regulators of cell differentiation and tissue and organ development. Several microRNA have been described to play a role in branching morphogenesis, a key step in early lung development. However, considerab...
Mesenchymal stromal cells in the development and therapy of bronchopulmonary dysplasia [0.03%]
间充质基质细胞在支气管肺发育不良的发病机制及治疗中的作用
Marius A Möbius,Mario Rüdiger
Marius A Möbius
Bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, remains a major healthcare burden. Despite great progresses in perinatal medicine over the past decades, no cure for BPD has been found. The complex pathophysiology ...
Alveologenesis: key cellular players and fibroblast growth factor 10 signaling [0.03%]
肺泡发生：关键细胞成分及成纤维细胞生长因子10信号通路
Cho-Ming Chao,Alena Moiseenko,Klaus-Peter Zimmer et al.
Cho-Ming Chao et al.
Background: Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epit...
Robert C Fellner,Shawn T Terryah,Robert Tarran
Robert C Fellner
Asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are all chronic pulmonary diseases, albeit with different etiologies, that are characterized by airflow limitation, chronic inflammation, and abnormal mucus prod...
Matthias C Hütten,Tim G A M Wolfs,Boris W Kramer
Matthias C Hütten
After birth, adequate lung function is necessary for the successful adaptation of a preterm baby. Both prenatal and postnatal insults and therapeutic interventions have an immediate effect on lung function and gas exchange but also interfer...
The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens [0.03%]
缺氧对肠上皮细胞功能的影响及其对细菌病原菌入侵的后果
Nathalie E Zeitouni,Sucheera Chotikatum,Maren von Köckritz-Blickwede et al.
Nathalie E Zeitouni et al.
The maintenance of oxygen homeostasis in human tissues is mediated by several cellular adaptations in response to low-oxygen stress, called hypoxia. A decrease in tissue oxygen levels is initially counteracted by increasing local blood flow...