Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.) [0.03%]
维生素D补充：营养委员会，德国儿科和青少年医学协会(DGKJ e. V.)及德国儿童内分泌学和糖尿病协会(DGKED e. V.)的联合立场声明——两岁后
Thomas Reinehr,Dirk Schnabel,Martin Wabitsch et al.
Thomas Reinehr et al.
Background: Low vitamin D serum concentrations have been associated with rickets and other disorders in observational studies. Since vitamin D serum concentrations in children and adolescents are frequently below referenc...
Complementary foods in baby food pouches: position statement from the Nutrition Commission of the German Society for Pediatrics and Adolescent Medicine (DGKJ, e.V.) [0.03%]
德国儿科和青少年医学协会(DGKJ，eV)营养委员会关于婴儿食品包装辅食的立场声明
Berthold Koletzko,Christoph Bührer,Regina Ensenauer et al.
Berthold Koletzko et al.
Pureed complementary feeding products packed in squeezable plastic pouches, usually with a spout and a screw cap, have been increasingly marketed. The Committee on Nutrition recommends that infants and young children should not suck pureed ...
KUNO-Kids birth cohort study: rationale, design, and cohort description [0.03%]
中国儿童出生队列研究：研究目的、设计与受试者特征描述
Susanne Brandstetter,Antoaneta A Toncheva,Jakob Niggel et al.
Susanne Brandstetter et al.
Background: Birth cohort studies can contribute substantially to the understanding of health and disease - in childhood and over the life course. The KUNO-Kids birth cohort study was established to investigate various asp...
Gene correction of HBB mutations in CD34+ hematopoietic stem cells using Cas9 mRNA and ssODN donors [0.03%]
使用Cas9信使RNA和单链寡核苷酸捐赠者在CD34阳性造血干细胞中纠正HBB突变
Justin S Antony,Ngadhnjim Latifi,A K M Ashiqul Haque et al.
Justin S Antony et al.
Background: β-Thalassemia is an inherited hematological disorder caused by mutations in the human hemoglobin beta (HBB) gene that reduce or abrogate β-globin expression. Although lentiviral-mediated expression of β-glo...
Chrysanthy Ikonomidou
Chrysanthy Ikonomidou
Survival rates of children with cancer are steadily increasing. This urges our attention to neurocognitive and psychiatric outcomes, as these can markedly influence the quality of life of these children. Neurobehavioral morbidity in childho...
The role of S100 proteins in the pathogenesis and monitoring of autoinflammatory diseases [0.03%]
S100蛋白在自身炎症性疾病发病机制和监测中的作用
Dirk Holzinger,Dirk Foell,Christoph Kessel
Dirk Holzinger
S100A8/A9 and S100A12 are released from activated monocytes and granulocytes and act as proinflammatory endogenous toll-like receptor (TLR)4-ligands. S100 serum concentrations correlate with disease activity, both during local and systemic ...
Stefan E G Burdach,Mike-Andrew Westhoff,Maximilian Felix Steinhauser et al.
Stefan E G Burdach et al.
Outcome in treatment of childhood cancers has improved dramatically since the 1970s. This success was largely achieved by the implementation of cooperative clinical research trial groups that standardized and developed treatment of childhoo...
Georg Varga,Dirk Foell
Georg Varga
Monocytes are central to our health as they contribute to both hemispheres of our immune system, the innate and the adaptive arm. Sensing signals from the outside world, monocytes govern the innate immunity by initiating inflammation, e.g.,...
Intrauterine growth restriction - impact on cardiovascular diseases later in life [0.03%]
宫内生长受限与成人期心血管疾病的关系
Carlos Menendez-Castro,Wolfgang Rascher,Andrea Hartner
Carlos Menendez-Castro
Intrauterine growth restriction (IUGR) is a fetal pathology which leads to increased risk for certain neonatal complications. Furthermore, clinical and experimental studies revealed that IUGR is associated with a significantly higher incide...
CISH promoter polymorphism effects on T cell cytokine receptor signaling and type 1 diabetes susceptibility [0.03%]
CISH启动子多态性对T细胞细胞因子受体信号转导及1型糖尿病易感性的影响
Julia Seyfarth,Heinz Ahlert,Joachim Rosenbauer et al.
Julia Seyfarth et al.
Background: Impaired regulatory T cell immunity plays a central role in the development of type 1 diabetes (T1D). Interleukin-2 receptor (IL-2R) signaling is essential for regulatory T cells (TREG), and cytokine-inducible...