Nup133 and ERα mediate the differential effects of hyperoxia-induced damage in male and female OPCs [0.03%]
Nup133和ERα介导高氧诱导的损伤在雄性和雌性OPCs中产生不同效果
Donna Elizabeth Sunny,Elke Hammer,Sebastian Strempel et al.
Donna Elizabeth Sunny et al.
Background: Hyperoxia is a well-known cause of cerebral white matter injury in preterm infants with male sex being an independent and critical risk factor for poor neurodevelopmental outcome. Sex is therefore being widely...
Julia Etich,Lennart Leßmeier,Mirko Rehberg et al.
Julia Etich et al.
Osteogenesis imperfecta (OI) is a rare congenital disease with a wide spectrum of severity characterized by skeletal deformity and increased bone fragility as well as additional, variable extraskeletal symptoms. Here, we present an overview...
Genotype-phenotype correlations in children and adolescents with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency [0.03%]
21-羟化酶缺乏非典型先天性肾上腺皮质增生患儿的基因型与表型相关性
Helmuth-Günther Dörr,Nadja Schulze,Markus Bettendorf et al.
Helmuth-Günther Dörr et al.
Background: Nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency is caused by mutations in the active 21-hydroxylase gene (CYP21A2). The clinical symptoms can vary greatly. To date, no systematic s...
Shivanthan Shanthikumar,Melanie R Neeland,Jovana Maksimovic et al.
Shivanthan Shanthikumar et al.
Biomarkers which predict future health outcomes are key to the goals of precision health. Such biomarkers do not have to be involved in the causal pathway of a disease, and their performance is best assessed using statistical tests of clini...
Infant formula with cow's milk fat and prebiotics affects intestinal flora, but not the incidence of infections during infancy in a double-blind randomized controlled trial [0.03%]
以乳脂肪和益生元的婴儿配方奶对肠道菌群有影响，但不能降低双盲随机对照试验中的感染发生率
Antonia Nomayo,Andreas Schwiertz,Rainer Rossi et al.
Antonia Nomayo et al.
Background: The postnatal intestinal colonization of human milk-fed and formula-fed infants differs substantially, as does the susceptibility to infectious diseases during infancy. Specific ingredients in human milk, such...
Pro-inflammatory cytokine ratios determine the clinical course of febrile neutropenia in children receiving chemotherapy [0.03%]
儿童化疗发热性中性粒细胞减少的预后与炎症因子比值相关
Mira Siegmund,Julia Pagel,Tasja Scholz et al.
Mira Siegmund et al.
Background: Febrile neutropenia is a common and serious complication during treatment of childhood cancer. Empirical broad-spectrum antibiotics are usually administered until neutrophil cell count recovery. It was the aim...
Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring [0.03%]
确认摄入咖啡因且产下早产儿孕妇群体中的CYP2E1代谢活性调节作用
M R Alcorta-García,C N López-Villaseñor,G Sánchez-Ferrer et al.
M R Alcorta-García et al.
Background: To ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm...
Shedding light on pediatric diseases: multispectral optoacoustic tomography at the doorway to clinical applications [0.03%]
儿科疾病光学声学断层扫描临床应用之门扉式多光谱仪
Adrian P Regensburger,Alexandra L Wagner,Jing Claussen et al.
Adrian P Regensburger et al.
Optoacoustic imaging (OAI), or photoacoustic imaging (PAI), has fundamentally influenced basic science by providing high-resolution visualization of biological mechanisms. With the introduction of multispectral optoacoustic tomography (MSOT...
Kenichi Kinjo,Tomoko Yoshida,Yoshitomo Kobori et al.
Kenichi Kinjo et al.
Background: X chromosome inactivation (XCI) is an indispensable process in the development of human female embryos. Reportedly, XCI occurs when a blastocyst contains 10-12 embryonic progenitor cells. To date, it remains u...
Shaping of the nephron - a complex, vulnerable, and poorly explored backdrop for noxae impairing nephrogenesis in the fetal human kidney [0.03%]
人胎肾受损背景下复杂的、易损的和研究较少的肾小管成形过程
Will W Minuth
Will W Minuth
Background: The impairment of nephrogenesis is caused by noxae, all of which are significantly different in molecular composition. These can cause an early termination of nephron development in preterm and low birth weigh...