The mutual patterning between the developing nephron and its covering tissues-valid reasons to rethink the search for traces left by impaired nephrogenesis [0.03%]
发育中的肾小球与其覆盖组织之间的相互作用模式之间存在的互惠模式-重新思考寻找肾小球发育不良留下的痕迹的有效理由
Will W Minuth
Will W Minuth
Background: The impairment of nephrogenesis can cause the termination of nephron formation in preterm and low birth weight babies. This leads to oligonephropathy with severe health consequences in later life. Although man...
Novel ways to monitor immunosuppression in pediatric kidney transplant recipients-underlying concepts and emerging data [0.03%]
儿科肾脏移植受者的免疫抑制监测的新方法-基本概念和最新数据
Thurid Ahlenstiel-Grunow,Lars Pape
Thurid Ahlenstiel-Grunow
After pediatric kidney transplantation, immunosuppressive therapy is given to avoid acute and chronic rejections. However, the immunosuppression causes an increased risk of severe viral complications and bacterial infections and is associat...
Tristan Römer,Norbert Wagner,Till Braunschweig et al.
Tristan Römer et al.
Background: Infantile myofibromatosis (IM) is the most common cause of multiple fibrous tumors in infancy. Multicentric disease can be associated with life-threatening visceral lesions. Germline gain-of-function mutations...
Identification of a novel MICU1 nonsense variant causes myopathy with extrapyramidal signs in an Iranian consanguineous family [0.03%]
识别出一个新颖的MICU1无义突变引起伊朗近亲结婚家系的肌病伴锥外体受累症状
Fatemeh Bitarafan,Mehrnoosh Khodaeian,Elham Amjadi Sardehaei et al.
Fatemeh Bitarafan et al.
Background: Ca2+ as a universal second messenger regulates basic biological functions including cell cycle, cell proliferation, cell differentiation, and cell death. Lack of the protein mitochondrial calcium uptake1 (MICU...
Daratumumab therapy for post-HSCT immune-mediated cytopenia: experiences from two pediatric cases and review of literature [0.03%]
达雷妥尤单抗治疗移植后免疫介导的血细胞减少症：2 例儿科患者治疗经验及文献回顾
Lina Driouk,Robert Schmitt,Anke Peters et al.
Lina Driouk et al.
Background: Immune-mediated cytopenias (AIC) are challenging complications following allogeneic hematopoietic stem cell transplantation (HSCT). While broad-acting immunosuppressive agents like corticosteroids are often st...
Combined RT-qPCR and pyrosequencing of a Spike glycoprotein polybasic cleavage motif can uncover pediatric SARS-CoV-2 infections associated with heterogeneous presentation [0.03%]
结合RT-qPCR和测序检测S蛋白多碱基裂解位点可发现临床表现各异的儿童新型冠状病毒感染者
Patrick Philipp Weil,Jacqueline Hentschel,Frank Schult et al.
Patrick Philipp Weil et al.
Background: Reverse transcription of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (+)RNA genome and subgenomic RNAs (sgRNAs) and subsequent quantitative polymerase chain reaction (RT-qPCR) is the relia...
Relationship between adiponectin, TNFα, and SHBG in prepubertal children with obesity [0.03%]
肥胖学龄前儿童脂联素、TNFα和SHBG的关联分析
Marta Ramon-Krauel,María Jesús Leal-Witt,Óscar Osorio-Conles et al.
Marta Ramon-Krauel et al.
Background: Sex hormone-binding globulin (SHBG) levels are low in adult subjects with obesity when compared to normal-weight individuals. Obesity is associated with higher tumor necrosis factor alpha (TNFα) plasma levels...
Molecular causes of congenital anomalies of the kidney and urinary tract (CAKUT) [0.03%]
儿童肾脏和泌尿道畸形(CAKUT)的分子病因学原因
Stefan Kohl,Sandra Habbig,Lutz T Weber et al.
Stefan Kohl et al.
Congenital anomalies of the kidney and urinary tract (CAKUT) occur in 0.5-1/100 newborns and as a group they represent the most frequent cause for chronic kidney failure in children. CAKUT comprise clinically heterogeneous conditions, rangi...
Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality [0.03%]
Ruvbl1基因敲除导致严重的表皮发育缺陷和围产期致死
Claudia Dafinger,Thomas Benzing,Jörg Dötsch et al.
Claudia Dafinger et al.
Epidermal development is a complex process of regulated cellular proliferation, differentiation, and tightly controlled cell death involving multiple cellular signaling networks. Here, we report a first description linking the AAA+ (ATPases...
Ruth Janoschek,Thorben Hoffmann,Yousef Ashraf Tawfik Morcos et al.
Ruth Janoschek et al.