Disease Course in Patients Switched from Natalizumab to Alemtuzumab: An Italian Multicenter, Prospective, Observational Study [0.03%]
意大利多中心前瞻性观察研究中由那他珠单抗转换为奥法木单抗患者的疾病转归分析
Simona Malucchi,Paola Perini,Francesca Rinaldi et al.
Simona Malucchi et al.
Introduction: Natalizumab is a highly efficacious therapy (HET) for patients with relapsing remitting multiple sclerosis (RRMS). Its prolonged use is limited by the risk of progressive multifocal leukoencephalopathy (PML)...
Pharmacokinetics, Pharmacodynamics, and Safety of Nipocalimab in Healthy Chinese Volunteers: A Single-Dose, Phase I Study [0.03%]
尼普卡利单抗在健康中国受试者中的药代动力学、药效学和安全性：一项单次给药I期临床试验
Haiyan Li,Juanfang Liu,Xiaohong Wang et al.
Haiyan Li et al.
Introduction: Nipocalimab is a high-affinity, fully human, immunoglobulin G (IgG) 1 monoclonal antibody that inhibits the neonatal Fc receptor. Nipocalimab is under development for the treatment of various IgG autoantibod...
Role of Immune Reconstitution Therapy with Cladribine Tablets in the Management of Relapsing Multiple Sclerosis in Older Patients [0.03%]
克拉屈滨片在老年复发性多发性硬化症患者免疫重建治疗中的作用
Raed Alroughani,Jihad Inshasi,Samar Farouk et al.
Raed Alroughani et al.
The pathophysiology and presentation of relapsing multiple sclerosis (RMS) differ importantly between younger and older patients. Older patients usually suffer fewer MS relapses but present with a chronically inflammatory phenotype (inflamm...
What Patients Don't Say and Physicians Don't Ask: A Needs Assessment in Myasthenia Gravis Integrating Patient and Healthcare Professional Perspectives [0.03%]
肌无力患者未表达的需求和医生未询问的问题：从患者和医务人员的视角进行需求评估
Cornelia Reyes Acosta,Ivo Vlaev,Alexis Rodriguez et al.
Cornelia Reyes Acosta et al.
Introduction: Myasthenia gravis (MG) is a rare, autoimmune neuromuscular disease characterized by unpredictable fluctuating muscle weakness. This unpredictability makes effective patient-healthcare professional (HCP) dial...
Understanding the Patient Experience of Advanced Parkinson's Disease: Qualitative Research with Patients and Expert Clinicians to Identify Symptoms and Associated Health-Related Quality of Life Impacts [0.03%]
帕金森病晚期患者就医体验定性研究：患者及专家医师合作识别病症及相关的生命质量影响因素
Nicola Williamson,Thomas Morel,Helena Bradley et al.
Nicola Williamson et al.
Introduction: Parkinson's disease (PD) is a progressive neurodegenerative condition, characterized by motor symptoms (MS) and non-motor symptoms (NMS). Currently, there is no global definition of advanced PD, but those in...
Network Meta-analysis of Randomized Controlled Trials Assessing Neuromodulation Therapies for Painful Diabetic Neuropathy [0.03%]
评估神经调控疗法治疗糖尿病性神经痛的随机对照试验的网络meta分析研究
Li Li,Xueqin Luo,Yong Liu et al.
Li Li et al.
Introduction: Neuromodulation therapies (including non-invasive and invasive neuromodulation) are being used to treat painful diabetic neuropathy (PDN). M...
Evaluating Cognitive Outcomes in Multiple Sclerosis: Real-World Impact of Ozanimod on Processing Speed Using BICAMS [0.03%]
奥扎莫德对多发性硬化患者处理速度的现实世界影响——利用BICAMS评估认知结局
Aurora Zanghì,Paola Sofia Di Filippo,Carlo Avolio et al.
Aurora Zanghì et al.
Introduction: Cognitive dysfunction represents a major burden in multiple sclerosis (MS). The impact on cognitive outcomes of ozanimod in real-world settings remains to be fully elucidated. ...
Advancing Future Amyotrophic Lateral Sclerosis Medicines by Incorporating The Patient Voice Into Patient-Centered Holistic Measurement Strategies for Clinical and Real-World Studies: Results from Targeted Literature Reviews [0.03%]
基于患者的声音，通过以患者为中心的全方位测量策略开发未来肌萎缩侧索硬化症药物：靶向文献回顾结果
Diana Rofail,Michael Chladek,Betsy Williams et al.
Diana Rofail et al.
Introduction: This analysis sought to understand the patient experience in amyotrophic lateral sclerosis (ALS) and to assess whether commonly used clinical outcome assessments (COAs) reliably and validly capture that expe...
The Modified Functional Status Questionnaire for Assessing Patients with Parkinson's Disease Psychosis Treated with Pimavanserin: A Post Hoc Analysis [0.03%]
艾司西酞普兰治疗帕金森病精神病患者的改良功能状态问卷评估：事后分析结果
Virgilio G H Evidente,Lambros Chrones,Ratna Revankar et al.
Virgilio G H Evidente et al.
Introduction: Over half of patients with Parkinson's disease experience psychosis (PDP) symptoms over the course of their disease. In addition to significantly impacting patients' health-related quality of life and cognit...
Feasibility of Identifying Acute Nontraumatic Intracerebral Hemorrhage Events Using Diagnostic Coding Among Veterans with Mild Cognitive Impairment or Alzheimer's Dementia [0.03%]
利用诊断编码在轻度认知障碍或阿尔茨海默病的老兵中识别急性非创伤性脑出血事件的可行性研究
Dan Berlowitz,Ying Wang,Joel Reisman et al.
Dan Berlowitz et al.
Introduction: Based on manual review of clinical notes of using the International Classification of Diseases, Tenth Revision coding, we evaluated the feasibility and validity for monitoring, recording, and reporting intra...