Summary of Research: Fertility Outcomes in Risdiplam-Treated Male Patients with Spinal Muscular Atrophy: A Multicenter Case Series [0.03%]
利司扑兰治疗脊髓性肌萎缩症的男性患者的生育结局多中心病例系列研究总结
Shelley Coskery,Marcus Erdler,Margaret R Frey et al.
Shelley Coskery et al.
This Summary of Research summarizes a previously published original article, "Fertility Outcomes in Risdiplam-Treated Male Patients with Spinal Muscular Atrophy: A Multicenter Case Series." Risdiplam (EVRYSDI®) is a medication approved for...
SGLT-2 Inhibitors in the Prevention and Progression of Neurodegenerative Diseases: A Narrative Review [0.03%]
钠葡萄糖协同转运蛋白-2抑制剂在神经退行性疾病预防和进展中的作用：叙述性综述
Paulina Kostrzewska,Paweł Kuca,Przemysław Witek et al.
Paulina Kostrzewska et al.
Neurodegenerative diseases are among the most prevalent and debilitating disorders in aging populations. Despite growing insights into their complex pathophysiology, effective disease-modifying treatments remain limited. Sodium-glucose cotr...
Cognitive Function and Proteomic Changes in Patients with Autoantibody-Positive Neurodegenerative Dementia [0.03%]
自身抗体阳性神经退行性痴呆患者的认知功能和蛋白质组学改变
Jin Gong,Chang Xu,Wenxian Sun et al.
Jin Gong et al.
Introduction: Neurodegenerative dementia (ND) is characterized by progressive cognitive decline. The role of autoantibodies in ND remains controversial, as they may contribute to neurological damage or, under certain path...
Selective S1P Receptor Modulation in Multiple Sclerosis Alters CXCL13:CXCR5-Associated Immune Activities Without Impacting Anti-SARS-CoV-2 Immunity [0.03%]
选择性S1P受体调节对多发性硬化症中CXCL13：CXCR5相关免疫活动的影响而不影响抗SARS-CoV-2免疫力
Andrea Harrer,Richard F Radlberger,Beate Buchegger et al.
Andrea Harrer et al.
Introduction: Sphingosine-1-phosphate receptor (S1PR) modulators are effective therapies for multiple sclerosis (MS) that block lymphocyte egress from secondary lymphoid organs. This migration inhibition carries the risk ...
The Use of Long-Acting Injectables for People with Schizophrenia: Consensus Panel Recommendations for Overcoming Barriers and Implementing Treatment [0.03%]
长效注射制剂在精神分裂症患者中应用的专家共识推荐：克服障碍和实施治疗建议
John M Kane,Ofer Agid,David J Castle et al.
John M Kane et al.
Introduction: Antipsychotic medications are effective for people living with schizophrenia, but long-term treatment adherence remains challenging, leading to relapses and poor outcomes. Long-acting injectable antipsychoti...
Comparative Efficacy of Double-Filtration Plasmapheresis Versus Intravenous Methylprednisolone in Acute Attacks of Neuromyelitis Optica Spectrum Disorder: A Prospective Cohort Study [0.03%]
双滤过血浆置换与静脉注射甲基泼尼松龙治疗视神经脊髓炎谱系病急性发作的疗效比较：一项前瞻性队列研究
Xiwen Ai,Qiuju Li,Kan Wang et al.
Xiwen Ai et al.
Introduction: While double-filtration plasmapheresis (DFPP) and intravenously administered methylprednisolone (IVMP) are both established treatments for acute attacks of neuromyelitis optica spectrum disorder (NMOSD), the...
Expert Guidance on Cognitive Impairment in Alzheimer's Disease: A Practical Seven-Step Approach from the United Arab Emirates [0.03%]
阿联酋阿尔茨海默病认知障碍专家指导：实际的七步方法
Tauofik Alsaadi,Abubaker Almadani,Suhail AlRukn et al.
Tauofik Alsaadi et al.
Introduction: Cognitive impairment (CI) spans a spectrum from mild CI to severe dementia, with Alzheimer's disease (AD) the most prevalent cause of CI and dementia. Although dementia burden and prevalence in Arab countrie...
Improvement in Motor Consistency and Stability with Foslevodopa/Foscarbidopa in Advanced Parkinson's Disease: Post Hoc Analysis of Two Phase 3 Clinical Trials [0.03%]
帕金森病晚期使用Fos Levodopa/Fos Carbidopa可改善运动的稳定性和一致性：两项3期临床试验的事后分析
Rajesh Pahwa,Jason Aldred,Michael J Soileau et al.
Rajesh Pahwa et al.
Introduction: People with advanced Parkinson's disease (aPD) frequently experience unpredictable "Off" time and debilitating motor fluctuations. Foslevodopa/foscarbidopa (LDp/CDp), a levodopa/carbidopa (LD/CD) prodrug, is...
Associations of Folate and Homocysteine Levels with Futile Recanalization in Acute Ischemic Stroke After Successful Endovascular Thrombectomy [0.03%]
叶酸和同型半胱氨酸水平与急性缺血性卒中血管内取栓成功后再灌注失败的相关性研究
Taoyuan Lu,Wenbo Cao,Bin Yang et al.
Taoyuan Lu et al.
Introduction: Our preliminary study identified two metabolically distinct thrombus subtypes, demonstrating enhanced lipid metabolic signatures but downregulated folate biosynthesis pathways associated with poor prognosis....
Associations of Folate and Homocysteine Levels with Futile Recanalization in Acute Ischemic Stroke After Successful Endovascular Thrombectomy [0.03%]
叶酸和同型半胱氨酸水平与急性缺血性卒中血管内治疗后无效再通的相关性研究
Taoyuan Lu,Wenbo Cao,Bin Yang et al.
Taoyuan Lu et al.
Introduction: Our preliminary study identified two metabolically distinct thrombus subtypes, demonstrating enhanced lipid metabolic signatures but downregulated folate biosynthesis pathways associated with poor prognosis....