Cenobamate for Adjunctive Treatment in Adult and Pediatric Patients with Refractory Lennox-Gastaut Syndrome: A Retrospective Chart Review [0.03%]
用于成人和儿童难治性Lennox-Gastaut综合征附加治疗的群氨苯甲酸：一项回顾性研究
Karen Keough,Alec Romick
Karen Keough
Introduction: Lennox-Gastaut syndrome (LGS) is a particularly severe developmental epileptic encephalopathy (DEE) characterized by multiple types of drug-resistant, incapacitating seizures. Despite aggressive therapy incl...
Comparative Effectiveness of Fumarates Versus Sphingosine-1-Phosphate Receptor Modulators in Black Patients with Multiple Sclerosis [0.03%]
比较马来酸盐和鞘氨醇-1-磷酸受体调节剂治疗黑人多发性硬化症患者的疗效研究
Sophia Woodson,Edward J Gettings,Chu-Yueh Guo et al.
Sophia Woodson et al.
Introduction: Multiple sclerosis (MS) is a heterogeneous disease that disproportionately impacts Black people with MS (PwMS), who experience more severe disease and higher relapse rates compared with non-Black populations...
Real-World Treatment Outcomes in Black, Hispanic, Asian, and White People with Multiple Sclerosis Treated with Fumarates in the USA [0.03%]
美国富马酸盐治疗的多发性硬化症患者中不同人种的真实世界预后状况
Sophia Woodson,Edward J Gettings,Chu-Yueh Guo et al.
Sophia Woodson et al.
Introduction: Multiple sclerosis (MS) is a heterogeneous disease affecting a diverse population. Compared with white people with MS (PwMS), Black PwMS have more severe disease and higher incidence of MS, whereas Hispanic ...
Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson's Disease [0.03%]
帕金森病进展和治疗效果评估的PARCOMS量表的编制及验证研究
Gil L&#x;Italien,Basia Rogula,Lauren Powell et al.
Gil L&#x;Italien et al.
Introduction: Measures designed to comprehensively assess Parkinson's disease (PD) irrespective of disease stage and treatment status may be unable to capture nuances in disease progression, particularly in early-stage PD...
Patient Experience of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease: Qualitative Patient and Clinician Interviews Informing the Development of a Conceptual Model [0.03%]
髓磷脂少突胶质细胞糖蛋白抗体相关疾病患者的体验：定性患者和临床医生访谈，为概念模型的开发提供信息
Jeffrey L Bennett,Asha Paireddy,Charlotte Cox et al.
Jeffrey L Bennett et al.
Introduction: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare, autoimmune demyelinating central nervous system disease. Currently, little is known about the signs, symptoms, and health-re...
Differentiation Between Early and Severe Stages of Dementia in Claims Data Based on Diagnosis, Prescription, and Utilization Patterns [0.03%]
基于诊断、处方和使用模式的理赔数据中痴呆早期和晚期的区别化研究
Moritz Platen,Maresa Buchholz,Anika Rädke et al.
Moritz Platen et al.
Introduction: Claims data typically lack clinical parameters such as dementia severity, limiting insights into disease progression and related healthcare utilization and costs. Although diagnoses, prescriptions, and utili...
Long-Term Safety and Efficacy of Repeated Cycles of RimabotulinumtoxinB in the Treatment of Chronic Sialorrhea: Results of the OPTIMYST Trial [0.03%]
替丹博林肉毒杆菌素 B 治疗重症流涎症的长期安全性和疗效：OPTIMYST 研究结果
Rajesh Pahwa,Eric Molho,Mark Lew et al.
Rajesh Pahwa et al.
Introduction: Botulinum toxin injections into the salivary glands inhibit saliva production by reducing the release of acetylcholine at the parasympathetic nerve terminals within the salivary gland. The phase 3 study repo...
Levodopa Intestinal Gel Infusion Therapies in Advanced Parkinson's Disease: A Swedish Study on Real-World Use and Costs [0.03%]
瑞典一项关于帕金森病晚期左旋多巴肠道凝胶输注治疗的现实世界使用及成本研究
Per Odin,Christoffer Tærud,Jenny Samuelsson et al.
Per Odin et al.
Introduction: This study evaluated real-world cassette use and cost of levodopa-carbidopa intestinal gel (LCIG; 2000 mg levodopa equivalent dose [LED]) and levodopa-entacapone-carbidopa intestinal gel (LECIG; 1250 mg LED)...
A Patient-centric Clinical Trial Design to Comprehensively Evaluate Low-Sodium Oxybate in People with Idiopathic Hypersomnia or Narcolepsy [0.03%]
以患者为中心的临床试验设计，全面评估低钠氧疗在特发性过度嗜睡或发作性睡眠症患者中的疗效
Deborah A Nichols,Teresa L Steininger,Douglas S Fuller et al.
Deborah A Nichols et al.
Introduction: Low-sodium oxybate (LXB; Xywav®) is approved to treat idiopathic hypersomnia in adults and excessive daytime sleepiness or cataplexy in individuals aged ≥ 7 years with narcolepsy. The efficacy and safety o...
Dysphagia Management is Associated with Reduced Mortality in Patients with Moderate to Severe Acute Ischemic Stroke [0.03%]
吞咽障碍管理与中重度急性缺血性卒中的死亡率降低相关
Julian Frederic Hotz,Lisa Kaindl,Lisa Schneider et al.
Julian Frederic Hotz et al.
Introduction: Dysphagia and pneumonia are common complications in patients with acute ischemic stroke (AIS), contributing to increased morbidity and mortality. This study evaluated the impact of pneumonia and dysphagia ma...