Safety and Effectiveness of Direct Oral Anticoagulants in Combination with Antiseizure Medications: Protocol for a Systematic Review and Meta-analysis [0.03%]
直接口服抗凝血药与抗癫痫药物联用的安全性和有效性：系统评价和meta分析方案
Kai Michael Schubert,Johan Zelano,David J Seiffge et al.
Kai Michael Schubert et al.
Introduction: The concurrent use of direct oral anticoagulants (DOACs) and antiseizure medications (ASMs) is increasingly common, particularly among patients with atrial fibrillation, stroke, and epilepsy. Certain ASMs ma...
Safety and Effectiveness of Direct Oral Anticoagulants in Combination with Antiseizure Medications: Protocol for a Systematic Review and Meta-analysis [0.03%]
直接口服抗凝药与抗癫痫药物联合使用的效果和安全性：系统评价和 meta 分析方案
Kai Michael Schubert,Johan Zelano,David J Seiffge et al.
Kai Michael Schubert et al.
Introduction: The concurrent use of direct oral anticoagulants (DOACs) and antiseizure medications (ASMs) is increasingly common, particularly among patients with atrial fibrillation, stroke, and epilepsy. Certain ASMs ma...
Perspective of Disease and Treatment in Patients with Multiple Sclerosis: A Polish Multi-center Study [0.03%]
多发性硬化病患者的疾病及治疗观念：波兰多中心研究的观点
Justyna Chojdak-Łukasiewicz,Alina Kułakowska,Joanna Tarasiuk et al.
Justyna Chojdak-Łukasiewicz et al.
Introduction: Due to recent progress in multiple sclerosis (MS) research, a range of disease-modifying therapies (DMT) is increasingly available. According to the personalized therapeutic approach, the choice of DMT for a...
Safety and Effectiveness of Satralizumab in Japanese Patients with Neuromyelitis Optica Spectrum Disorder: A 30‑Month Interim Analysis of Post‑marketing Surveillance [0.03%]
司妥昔单抗治疗视神经脊髓炎谱系障碍患者的日本真实世界研究中期分析
Takashi Yamamura,Noriko Isobe,Izumi Kawachi et al.
Takashi Yamamura et al.
Introduction: A large-scale post-marketing surveillance (PMS) study is ongoing to evaluate the safety and effectiveness of satralizumab over 6 years in Japanese patients with neuromyelitis optica spectrum disorder (NMOSD)...
Impact of Adjunctive Istradefylline on Dyskinesia Onset in Patients with Parkinson's Disease Exhibiting Wearing-Off: An Open-Label Randomized Controlled Trial [0.03%]
普拉克索佐剂对帕金森病患者运动波动导致的异动症发生的影响：一项开放标签随机对照试验
Yoshio Tsuboi,Takafumi Hasegawa,Yasushi Shimo et al.
Yoshio Tsuboi et al.
Introduction: Motor complications become major treatment challenges in patients with Parkinson's disease (PD). Istradefylline (IST) is used as an adjunct to levodopa in patients with PD exhibiting wearing-off (WO), but it...
Neurofilament Light Chain Levels as Diagnostic and Prognostic Biomarkers in Guillain-Barré Syndrome: An Updated Systematic Review and Meta-Analysis [0.03%]
神经丝轻链水平作为诊断和预测吉兰-巴雷综合征生物标志物的系统评价和meta分析（更新版）
Giovanni Siconolfi,Francesca Vitali,Maria Ausilia Sciarrone et al.
Giovanni Siconolfi et al.
Introduction: Guillain-Barré syndrome (GBS) is an acute immune-mediated disorder of the peripheral nervous system, marked by rapid onset of neurological symptoms. Despite progress in understanding the etiology and improv...
Testing the Clinical Dementia Rating Sum of Boxes as an Outcome for Dementia with Lewy Bodies Clinical Trials [0.03%]
路易体痴呆临床试验中检测临床痴呆评定量表综合评分作为疗效指标的效果
James E Galvin,Andres Salcedo
James E Galvin
Introduction: Dementia with Lewy bodies (DLB), a common cause of dementia, has no FDA-approved therapies, and clinical trials to date have had limited ability to demonstrate efficacy. The lack of validated DLB-specific cl...
Real-World 24-Month Outcomes of Ofatumumab in Relapsing Multiple Sclerosis: Efficacy, Safety, and the Impact of Frailty [0.03%]
奥扎莫德治疗复发型多发性硬化症的现实世界24个月结果：有效性、安全性及其对衰弱的影响
Gina Ferrazzano,Roberta Fantozzi,Shalom Haggiag et al.
Gina Ferrazzano et al.
Introduction: Ofatumumab (OFA) is a highly effective therapeutic option for multiple sclerosis (MS), but real-world data on its efficacy and safety remain limited. We evaluated the real-world efficacy and safety of OFA in...
The Difficult Journey of a Child with Dravet Syndrome: Perspectives from a Parent and the Neuropaediatrician [0.03%]
Dravet综合征患儿的艰难历程——父母与神经儿科医生的观点
Romain Reboux,Silvia Napuri
Romain Reboux
Dravet syndrome (DS) is a rare and severe form of epilepsy, characterised by recurrent seizures that begin during the first year of life, leading to motor, cognitive and behavioural impairments. This article provides the perspectives of a p...
Microglial Polarization and Therapeutic Strategies in Post-stroke Neuroinflammation [0.03%]
卒中后神经炎症中的小胶质细胞极化及治疗策略
Travis Yui Hei Chan,Brian De Yu Ma,Timothy Keith Hung et al.
Travis Yui Hei Chan et al.
Stroke remains a leading cause of global disability, perpetuated by maladaptive neuroinflammation that drives secondary injury and impairs recovery. An early reparative (M2) state rapidly transitions into a dominant destructive (M1) phenoty...