Sudoscan in ATTRv Amyloidosis: A Potential Marker of Disease Progression? [0.03%]
Sudoscan在ATTRv型淀粉样变性中的应用：疾病进展的潜在标志物？
Angela Romano,Valeria Guglielmino,Francesca Vitali et al.
Angela Romano et al.
Introduction: Hereditary transthyretin amyloidosis (ATTRv amyloidosis) is a severe, autosomal dominant disease resulting from multisystemic extracellular deposition of amyloid fibrils, leading to progressive organ damage ...
Menopause, Perimenopause, and Migraine: Understanding the Intersections and Implications for Treatment [0.03%]
更年期，围绝经期和偏头痛：理解它们的交叉点及其对治疗的影响
Marta Waliszewska-Prosół,Giovanni Grandi,Raffaele Ornello et al.
Marta Waliszewska-Prosół et al.
Migraine affects women three times more often than it does men, and various mechanisms may explain this incidence, including the key role of female sex hormones. Fluctuations in the levels of these hormones and their feedback control regula...
Adjunctive Brivaracetam in People with Epilepsy and Intellectual Disability: Evidence from the BRIVAracetam Add-On First Italian netwoRk Study [0.03%]
BRIVAracetam Add-On First意大利网络研究提供的证据：辅助Brivaracetam在癫痫和智力障碍人群中应用
Simona Lattanzi,Laura Canafoglia,Maria Paola Canevini et al.
Simona Lattanzi et al.
Introduction: Subjects with intellectual disability are usually excluded from clinical trials and there is limited evidence-based guidance for the choice of antiseizure medications in this vulnerable population. The study...
Factors Influencing the Response of Patients with Infantile Epileptic Spasms Syndrome to ACTH as Repeated First-Line Therapy [0.03%]
婴儿痉挛症患者对ACTH反复作为一线治疗反应的影响因素
Wenrong Ge,Ping Pang,Ziyan Zhang et al.
Wenrong Ge et al.
Introduction: The treatment of infantile epileptic spasms syndrome (IESS) aims to achieve spasm control. Current first-line interventions include hormone therapy (adrenocorticotropic hormone [ACTH] and corticosteroids) an...
Expert-Agreed Practical Recommendations on the Use of Fenfluramine in Developmental and Epileptic Encephalopathies Based on Clinical Experience and Literature Review [0.03%]
基于临床经验和文献回顾的芬氟拉明在发育性和癫痫性脑病中应用的专家一致实用建议
Vicente Villanueva,Victor Soto-Insuga,Patricia Smeyers et al.
Vicente Villanueva et al.
Introduction: Fenfluramine (FFA) represents the latest therapeutic option approved for seizure management in Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) for patients aged ≥ 2 years. This article provides exper...
A Multi-omics Framework Based on Machine Learning as a Predictor of Cognitive Impairment Progression in Early Parkinson's Disease [0.03%]
基于机器学习的多组学框架作为早期帕金森病认知障碍进展的预测器
Yang Luo,YaQin Xiang,JiaBin Liu et al.
Yang Luo et al.
Introduction: Cognitive impairment (CI) is a common non-motor symptom of Parkinson's disease (PD). However, the diagnosis and prediction of CI progression in PD remain challenging. We aimed to explore a multi-omics framew...
Health-Related Quality of Life and Cognitive Performance During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures: A Prospective, Observational Study in Europe [0.03%]
在欧洲对存在局灶性发作癫痫的患者进行为期12个月的联合式使用布瓦西坦治疗的效果：一项前瞻性的观察研究
Eduardo Rubio-Nazabal,Marian Majoie,Anne-Liv Schulz et al.
Eduardo Rubio-Nazabal et al.
Introduction: This analysis aimed to evaluate patient-related outcomes for health-related quality of life (HRQoL) and cognitive performance in patients (≥ 16 years) with focal-onset seizures (FOS), with/without focal to ...
Effectiveness During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures in a Real-Life Setting: A Prospective, Observational Study in Europe [0.03%]
在真实世界环境下接受Brivaracetam辅助治疗局灶性癫痫发作的患者中，为期12个月的有效性的研究：欧洲一项前瞻观察性研究
Bernhard J Steinhoff,Jakob Christensen,Colin P Doherty et al.
Bernhard J Steinhoff et al.
Introduction: Efficacy/tolerability of adjunctive brivaracetam (BRV) for focal-onset seizures (FOS) in patients aged ≥ 16 years was established in randomized controlled trials. This study aimed to evaluate the effectiven...
Prolonged Hospital Length of Stay Does Not Improve Functional Outcome in Acute Ischemic Stroke [0.03%]
急性缺血性卒中患者住院时间延长并不能改善功能预后
Yuxuan Lu,Peng Sun,Haiqiang Jin et al.
Yuxuan Lu et al.
Introduction: Ischemic stroke is the second leading cause of mortality and a major contributor to disability worldwide. Hospital length of stay (LOS) is a marker of medical efficiency for stroke care. There is limited inf...
Risk of Exacerbation and Level of Healthcare Resource Utilization in Myasthenia Gravis Assessed by Myasthenia Gravis Activities of Daily Living Score [0.03%]
肌无力日常生活能力评分评估的重症肌无力加剧风险和医疗资源利用程度
Angela Ting,Minjee Park,Oshin Sangha et al.
Angela Ting et al.
Introduction: Limited data are available on the relationship between myasthenia gravis (MG) severity and MG exacerbations and healthcare resource utilization (HCRU) following exacerbations. The objective of this study was...