Preferences of Dutch Parents and Expectant Parents for Respiratory Syncytial Virus Prevention Strategies: A Discrete Choice Experiment [0.03%]
荷兰父母和待产家长对呼吸道合胞病毒预防策略的偏好：离散选择实验
Annefleur C Langedijk,Floris van den Dungen,Lisette Harteveld et al.
Annefleur C Langedijk et al.
Introduction: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infection in infants. This study examined the preferences of Dutch parents and expectant parents for two RSV prevention...
Temporal Dynamics of SARS-CoV-2 Detection in Household Contacts: Divergences Between Time to First Positive Test, Symptom Onset, and Maximum Viral Load [0.03%]
家庭接触者中SARS-CoV-2检测的动态变化：首次阳性测试时间、症状出现时间和最大病毒载量之间的差异
Annemarie Berger,Ana M Groh,Damian Diaz et al.
Annemarie Berger et al.
Introduction: Understanding the temporal dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for optimizing diagnostic strategies. This prospective cohort study aimed to quantify ...
Lung Health and Respiratory Syncytial Virus: Podcast of a Patient-Physician Discussion Based on Insights from a Patient Advisory Board Meeting [0.03%]
基于患者咨询委员会会议见解的患者与医师会谈的 podcast：有关呼吸合胞病毒与肺健康的讨论
Bela Vatsa,Lisa McNeil,Peter Deussen et al.
Bela Vatsa et al.
An advisory board meeting was held with five participants living with chronic respiratory conditions or having experienced a severe episode of respiratory syncytial virus (RSV) infection, to understand the challenges faced by such individua...
Optimizing Polymyxin B Therapy in Critical Care: Pharmacokinetic Insights and Clinical Outcomes in a Retrospective Cohort Study [0.03%]
危重症患者多黏菌素B治疗优化：一项回顾性队列研究中的药代动力学见解和临床结局
Qingyun Peng,Qing Li,Mengru Xiong et al.
Qingyun Peng et al.
Introduction: Carbapenem-resistant Gram-negative bacteria pose significant global health threats due to high infection rates and limited treatment options. Polymyxin B (PMB) has reemerged as a last-line therapy against th...
Antiviral Combination Treatment for COVID-19 in Immunocompromised Patients: Towards Defining Its Place in Therapy [0.03%]
免疫缺陷患者的新冠抗病毒联合治疗：定义其在治疗中的地位
Chiara Sepulcri,Claudia Bartalucci,Elisa Balletto et al.
Chiara Sepulcri et al.
Introduction: Antiviral combinations have been successfully used to treat COVID-19 in immunocompromised patients, especially those with prolonged viral shedding or relapses. This study assessed outcomes of antiviral combi...
The Role of Protease Inhibitors in HIV Treatment: Who Still Needs Them in 2025? [0.03%]
艾滋病治疗中蛋白酶抑制剂的作用：谁还需要它们(直到2025年)?
Abiu Sempere,Rodrigo Alonso,Leire Berrocal et al.
Abiu Sempere et al.
Introduction: Protease inhibitors (PIs) remain an effective antiretroviral therapy (ART) option for people with human immunodeficiency virus (HIV) (PWH), particularly in complex clinical and virological scenarios. Howeve...
The Effects of Cobicistat and Voriconazole on the Safety, Pharmacokinetics, and Pharmacodynamics of the TLR7 Agonist Vesatolimod in People with HIV [0.03%]
Cobicistat和Voriconazole对TLR7激动剂vesatolimod在HIV患者中的安全性、药代动力学和药效学的影响
Yanan Zheng,Mary Wire,Robert Were Omange et al.
Yanan Zheng et al.
Introduction: Vesatolimod (VES), a toll-like receptor 7 agonist, is being investigated as part of a strategy for human immunodeficiency virus (HIV) cure. VES is metabolized through the CYP3A pathway and is a substrate of ...
Estimating the Burden of Mild-to-Moderate Varicella-Related Infections by Medical Helpline Usage: A Time Series Analysis from 2015 to 2023 Among Children in Denmark [0.03%]
基于丹麦2015年至2023年儿童医疗咨询热线使用情况的时间序列分析估算轻至中度水痘相关感染的疾病负担
Amanda Marie Egeskov-Cavling,Caroline Klint Johannesen,Omid Rezahosseini et al.
Amanda Marie Egeskov-Cavling et al.
Introduction: In the absence of a national varicella vaccine program, it is assumed that the annual proportion of children in Denmark acquiring a varicella infection (chickenpox) corresponds to the birth cohort size, appr...
Analysis of Adverse Drug Reactions of Clofazimine Reported in the FDA Adverse Event Reporting System from 2004 to 2025 Q1 [0.03%]
2004年至2025年第一季度FDA不良事件报告系统中克洛法齐明的不良反应分析
Ruoyu Zhang,Yunwen Tao,Ziwei Bao et al.
Ruoyu Zhang et al.
Introduction: Clofazimine (CFZ) is an antimycobacterial agent used primarily for leprosy and multidrug-resistant tuberculosis. Despite its long clinical history, comprehensive pharmacovigilance data remain limited. This s...
Cardiovascular Safety of COVID-19 Treatments: A Disproportionality Analysis of Adverse Event Reports from the WHO VigiBase [0.03%]
新冠肺炎治疗药物的心血管安全性：一项WHO VigiBase数据库中的不良事件信号检测分析研究
Hoi K Cheng,Angel Lai,Maxwell Kwok et al.
Hoi K Cheng et al.
Introduction: The high mortality of Coronavirus Disease 2019 (COVID-19) highlights the need for safe and effective antiviral treatment. Small molecular antivirals (remdesivir, molnupiravir, nirmatrelvir/ritonavir) and imm...