All-In-One Magnetic Nanoparticles for Thermo-Immunotherapy of Malignant Melanoma [0.03%]
用于恶性黑色素瘤热-免疫治疗的一体式磁性纳米粒子
Masahiro Kaneko,Rintaro Saito,Ami Nishikawa et al.
Masahiro Kaneko et al.
Hyperthermia using magnetic nanoparticles is a promising cancer therapy that locally destroys tumors and induces antitumor immunity by releasing tumor antigens from dying cells. However, magnetic hyperthermia in malignant melanomas with poo...
Inflamed Tissue-Targeting Polyphenol-Condensed Antioxidant Nanoparticles with Therapeutic Potential [0.03%]
具有治疗潜力的针对炎症组织的聚酚缩抗氧化纳米粒子
Dohyub Jang,Honghwan Choi,Juhyang Lee et al.
Dohyub Jang et al.
Inflammation is essential for pathogen eradication and tissue repair; However, chronic inflammation can bring on multi-organ dysfunction due to an overproduction of reactive oxygen species (ROS). Among various anti-inflammatory agents, poly...
Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy [0.03%]
基于二氧化铈纳米粒子的检视器通过增强线粒体质量控制来维持骨关节炎治疗中的软骨细胞稳态
Li Chen,Jianye Yang,Zhengwei Cai et al.
Li Chen et al.
Imbalanced mitochondrial quality control is strongly linked to the onset and development of osteoarthritis (OA). However, current research primarily focuses on local cartilage repair and phenotype maintenance, lacking a systematic approach ...
Ultrasensitive Detection of FEN1 Activity for Cancer Diagnosis Using a CRISPR/Cas13a-Based Triple Cascade Amplification System [0.03%]
利用基于CRISPR / Cas13a的三重级联放大系统对FEN1活性进行超灵敏检测用于癌症诊断
Xia Cheng,Wenchen Zhao,Daixi Chen et al.
Xia Cheng et al.
Flap endonuclease 1 (FEN1) is closely associated with tumor progression and proliferation, making it a promising biomarker for cancer diagnosis. However, developing a sensitive, reliable, and user-friendly method for quantitative FEN1 detec...
Advanced Toolboxes for Cryobioprinting Human Tissue Analogs [0.03%]
用于打印人类组织类似物的高级工具箱cryobioprinting中的高级工具箱
Francisca P Correia,Maria V Monteiro,Mafalda Borralho et al.
Francisca P Correia et al.
The increasing demand for biofabricating human tissue analogs for therapeutic applications has encouraged the pursuit of innovative techniques that shift from conventional bioprint-to-use approaches toward instantaneous bioprint-cryopreserv...
"Therapies Through Gut:" Targeted Drug Delivery for Non-Gastrointestinal Diseases by Oral Administration [0.03%]
通过肠道的治疗：口服非胃肠疾病靶向药物递送
Subarna Ray,Shehzahdi S Moonshi,Hang Thu Ta
Subarna Ray
Oral drug delivery is a promising approach for the treatment of various gastrointestinal (GI) diseases but poses significant challenges to target non-GI diseases. The intestinal barrier forms a significant anatomical challenge to reach the ...
Porous PtCu Alloys Decode Plasma Metabolic Fingerprints for the Recognition of Severe Community-Acquired Pneumonia [0.03%]
多孔PtCu合金解码等离子代谢指纹识别重症社区获得性肺炎
Kexin Meng,Yao Shen,Dongni Hou et al.
Kexin Meng et al.
Rapid and accurate recognition of severe community-acquired pneumonia (CAP) would facilitate the optimal intervention. Currently, the diagnosis of severe CAP is commonly based on the criteria established by Infectious Disease Society of Ame...
Dual-Functional Hafnium Oxide Nanoplatform Combining High-Z Radiosensitization With Bcl-2 Gene Silencing for Enhanced Cancer Radiotherapy [0.03%]
集高Z放疗增敏和Bcl-2基因沉默化療增效功能于一体的双功能核氧化物纳米平台用于增强癌症放射治疗
Seungyong Shin,Ga-Hyun Bae,Jun-Hyeok Han et al.
Seungyong Shin et al.
The efficacy of radiotherapy is often limited by insufficient radiosensitization and tumor radioresistance. This study reports a dual-functional hafnium oxide nanoplatform that combines high-Z radiosensitization with Bcl-2 gene silencing fo...
Advancing Chronic Wound Healing through Electrical Stimulation and Adipose-Derived Stem Cells [0.03%]
通过电刺激和脂肪来源的干细胞促进慢性伤口愈合
Qiuyue Peng,Yu Qian,Xinxin Xiao et al.
Qiuyue Peng et al.
Chronic cutaneous wounds are a major clinical challenge worldwide due to delayed healing, recurrent infections, and resistance to conventional therapies. Adipose-derived stem cells (ASCs) have shown promise as a cell-based therapy, but thei...
Dual Functional Radioactive Gel-Microspheres for Combinatorial Radioembolization and Photothermal Therapy of Hepatocellular Carcinoma [0.03%]
兼具放射栓塞和光热治疗功能的治疗肝细胞癌的双重功能放疗水凝胶微球
Jing Sun,Xingwei Sun,Liang Yin et al.
Jing Sun et al.
Transarterial radioembolization (TARE) is an established clinical therapy for treating patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who cannot undergo radical treatment. However, the delivery of a high radi...