Silk Nonwoven Fabric-Based Dressing with Antibacterial and ROS-Scavenging Properties for Modulating Wound Microenvironment and Promoting Diabetic Wound Healing [0.03%]
具有抗菌和ROS清除特性的丝蛋白非织造布敷料，用于调节伤口微环境和促进糖尿病伤口愈合
Zhao-Xi Zhou,Yanbin Chen,Jingyi Li et al.
Zhao-Xi Zhou et al.
The microenvironment of diabetic wounds is exceptionally complex, characterized notably by persistent bacterial infections and the excessive production of reactive oxygen species (ROS). Traditional treatment methods often fall short of achi...
A Dual-Layer Hydrogel Barrier Integrating Bio-Adhesive and Anti-Adhesive Properties Prevents Postoperative Abdominal Adhesions [0.03%]
结合生物粘附性和抗粘附性的双层水凝胶屏障防止术后腹腔粘连
Mena Asha Krishnan,Olawale A Alimi,Mitchell Kuss et al.
Mena Asha Krishnan et al.
Postoperative abdominal adhesions are a common and painful complication after surgery, leading to high healthcare costs and diminished quality of life. This report presents a novel bilayer hydrogel barrier featuring an inner adhesive layer ...
Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound [0.03%]
具有溶解黄酮的自愈水凝胶敷料用于糖尿病伤口全层再生
Qiang Zeng,Sa Du,Rui Yuan et al.
Qiang Zeng et al.
Hydrogels are soft, tissue-like materials that have great potential as wound dressings. However, most hydrogels are unsatisfactory in achieving whole-layer regeneration of diabetic wounds due to the complex pathological microenvironment and...
Nanohybrid Hydrogel with Dual Functions: Controlled Low-Temperature Photothermal Antibacterial Activity and Promoted Regeneration for Treating MRSA-Infected Bone Defects [0.03%]
具有双重功能的纳米杂化水凝胶：低温光热抗菌活性控制和促进再生治疗耐甲氧西林金黄色葡萄球菌感染性骨缺损
Fang Yang,Zewen Shi,Yiwei Hu et al.
Fang Yang et al.
Methicillin-resistant Staphylococcus aureus (MRSA)-related bone defects pose significant clinical challenges due to treatment failures. Here, an injectable nanohybrid hydrogel (FND-ZHD) is developed that combines controlled low-temperature ...
β-Diketone Functionalized Microspheres Chelate Reactive Iron via Metal Coordination for Cartilage Repair [0.03%]
β-二酮功能化微球通过金属配位螯合反应性铁以修复软骨
Yong Xu,Xin Gu,Xingchen Li et al.
Yong Xu et al.
Excessive intracellular iron accumulation can induce mitochondrial dysfunction, leading to chondrocyte ferroptosis, a key contributor to cartilage damage in osteoarthritis (OA). Here, micelle-microfluidic hydrogel microspheres, featuring ke...
Hepatoma Metastasis-Inhibiting Supramolecular Nanoglycocalyx for Enhanced Type I Photodynamic Therapy [0.03%]
用于增强I型光动力疗法的抑制肝癌转移超分子纳米糖萼
Yi-Chen Liu,Gai-Li Feng,Jia-Long Jie et al.
Yi-Chen Liu et al.
Type I photodynamic therapy (PDT) is well demonstrated to have low oxygen dependency. However, fully suppressing the risk of hypoxia-induced tumor metastasis during PDT remains a great challenge. In this study, a tetra-lactosylated amphiphi...
pH-Responsive Engineered Exosomes Enhance Endogenous Hyaluronan Production by Reprogramming Chondrocytes for Cartilage Repair [0.03%]
响应 pH 工程化外泌体通过重新编程软骨细胞促进内源性透明质酸的生成以修复软骨损伤
Xiaodan Wu,Weiyong Tao,Ziyang Lan et al.
Xiaodan Wu et al.
Trauma or inflammation-caused cartilage injury leads to joint dysfunction and pain. Exogenous hyaluronic acid (HA) injection is a well-established treatment, but it has a short duration in vivo and requires multiple injections. Here, a new ...
Matrix Viscoelasticity Orchestrates Osteogenesis via Mechanotransduction Mediated Metabolic Switch in Macrophages [0.03%]
矩阵黏弹性通过巨噬细胞中介的机械转导代谢开关来调控成骨过程
Dihao Tao,Hanzhe Wang,Shiping Chang et al.
Dihao Tao et al.
Understanding the interplay between extracellular matrix (ECM) mechanics and macrophage cellular processes is crucial for bone regeneration. While ECM stiffness has been extensively studied, the role of ECM viscoelasticity (e.g., stress rel...
Microenvironment-Regulated Hydrogels Prepared with a Brand-New Small Molecule Cross-Linker for Stepwise Treatment of Myocardial Infarction [0.03%]
采用新型小分子交联剂制备的微环境调控水凝胶用于心肌梗死序贯治疗研究
Yu Wu,Wen Zhang,Linlin Huang et al.
Yu Wu et al.
Despite the development of many injectable hydrogels intended for the repair of myocardial infarction (MI), their effectiveness is often compromised because they target merely one or two phases of MI's pathological progression. Here, a mult...
CircAars-Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis [0.03%]
CircAars修饰的ADSCs通过成骨分化、巨噬极化和促进血管生成的协同作用修复颌面部骨缺损
Yi He,Yunyang Lu,Runze Li et al.
Yi He et al.
Adipose-derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self-renewal capacity and easy accessibility. However, their limited osteogenic potential remains a critical challenge for clinical applicat...