Unlocking the Gates: A Novel Diagnostic Molecule for Quantifying Efflux Levels in Gram-Positive Bacteria [0.03%]
开启大门：一种用于量化阳性菌外排水平的新诊断分子
Mrunal Patil,Tatiana Munteanu,Gaël Brasseur et al.
Mrunal Patil et al.
Efflux-mediated antibiotic resistance poses a significant global threat, affecting diverse bacterial species. Clinicians recognize the danger of efflux mechanisms during antibiotic treatment, yet precise diagnostic tools remain unavailable....
An In Situ Curing, Shear-Responsive Biomaterial Designed for Durable Embolization of Microvasculature [0.03%]
一种用于微血管持久闭塞的原位固化、切变响应生物材料设计
Quynh P Pham,Jeffrey V Groom nd,Chander Sadasivan et al.
Quynh P Pham et al.
Endovascular embolization is a minimally-invasive technique whereby blood vessels supplying pathological structures are selectively occluded with various embolic agents. In many scenarios, it is desirable for the embolic to distally penetra...
Supramolecular Additive Screening to Engineer Microfibrous Rafts for Expansion of Pluripotent Stem Cells in Dynamic Suspension [0.03%]
用于动态悬浮培养中多能干细胞扩增的超分子添加剂筛选以构建微纤维筏
Johnick F van Sprang,Jasper G M Aarts,Boris Arts et al.
Johnick F van Sprang et al.
Human induced pluripotent stem cells (hiPSCs) hold the potential to generate any human tissue for transplantation in regenerative therapies. These complex cell therapies require billions of cells, which is challenging to acquire in planar a...
Non-Covalent Interaction Induced Supramolecular Precipitate with Hetero-Motif Polyionic Junction for Durable Antimicrobial Activity and Infected Wound Healing [0.03%]
具有异型多离子连接的非共价作用诱导超分子沉淀物在感染创面愈合中表现出持久的抗微生物活性
Xuejiao Wang,Lianbo He,Huanling He et al.
Xuejiao Wang et al.
The advent of the COVID-19 pandemic has underscored the pressing demand for antimicrobial materials that offer both durability and efficacy. Herein, the successful design and fabrication of a "water-insoluble" supramolecular precipitate is ...
A Sophisticated Ratiometric Nuclear Medicine Imaging Strategy for Biological Microenvironment Abnormal Factor Detection [0.03%]
一种复杂的比率核医学成像生物微环境异常因子检测策略
Jianxian Ge,Haodi Qi,Lishu Zhao et al.
Jianxian Ge et al.
Biological microenvironment detection is crucial for deciphering the mechanisms underlying malignant progression and predicting the treatment efficacy of diseases. Nevertheless, only very limited progress has been made toward non-invasive a...
Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers [0.03%]
气体信号分子在现代医学中的应用前景和挑战：多孔晶体载体的使用
Rosana V Pinto,Moisés L Pinto,Christian Serre
Rosana V Pinto
Gas therapy using gasotransmitters is of exponential interest due to the growing recognition of gas signaling molecules that can be involved in multiple therapeutic actions. Finding suitable methods for delivering these molecules is crucial...
Prevascularized Hydrogel Enhancing Innervation and Repair of Full-Thickness Volumetric Muscle Loss in Abdominal Wall Defects [0.03%]
预血管化的水凝胶可以提高腹部缺损中全层肌肉体积损失的神经支配和修复能力
Chia-Chang Hsieh,Jun-Zhi Dai,Chun-Chuan Ni et al.
Chia-Chang Hsieh et al.
Current materials for repairing abdominal peritoneal defects face rapid degradation, infection risk, insufficient vascular ingrowth, slow muscle regeneration, and suboptimal postoperative integration, often causing fibrotic healing and hind...
Intended Mismatch DNA Nanocomplexes for Ultrasensitive, Enzymatic Colorimetric Detection of MPOX Virus in Minutes Using a Paper-Based Fast-Flow Micromixing Device [0.03%]
用于在几分钟内利用纸基快速混合设备超灵敏、酶比色检测MPOX病毒的故意错配DNA纳米复合物
Lalitphan Hongtanee,Sudkate Chaiyo,Hongkai Wu et al.
Lalitphan Hongtanee et al.
In 2024, mpox (formerly "monkeypox") re-emerged as a global health threat due to the more severe Clade I strain, underscoring the need for rapid, accessible diagnostics. Traditional polymerase chain reaction (PCR) methods, while effective, ...
An Intervertebral Disc (IVD) Regeneration Model Using Human Nucleus Pulposus Cells (iHNPCs) and Annulus Fibrosus Cells (iHAFCs) [0.03%]
使用人髓核细胞(iHNPCs)和纤维环细胞(iHAFCs)的椎间盘再生模型研究
Yi Zhu,Qing Liu,Chao Yu et al.
Yi Zhu et al.
Intervertebral disc (IVD) degeneration (IVDD), primarily caused by nucleus pulposus (NP) dehydration, leads to low back pain. While current treatments focus on symptom management or surgical intervention, tissue engineering using IVD-derive...
In Situ-Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)-Based Hydrogels Integrating Bound Quaternary Ammonia Compounds and Antibiotic Functionalities for Effective Infected Wound Healing [0.03%]
包含季铵盐化合物和抗生素功能的原位凝胶抗菌聚(低聚乙二醇甲基丙烯酸酯)水凝胶在感染伤口愈合中的应用研究
Fei Xu,Evelyn Cudmore,Sadru-Dean Walji et al.
Fei Xu et al.
In situ-gelling antibacterial hydrogels are reported in which two antibacterial entities (quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP)) are tethered to a single precursor based on the anti-fouling polymer poly(olig...