An Energy Metabolism Nanoblocker for Cutting Tumor Cell Respiration and Inhibiting Mitochondrial Hijacking from Cytotoxic T Lymphocyte [0.03%]
切断肿瘤细胞呼吸和抑制来自细胞毒性T淋巴细胞的线粒体劫持的代谢纳米阻断剂
Xiaojing Leng,Yang Yang,Tao Jiang et al.
Xiaojing Leng et al.
Energy metabolism modulation emerges as a highly regarded strategy for tumor therapy. However, the efficacy of targeting energy metabolism in tumor cells remains unsatisfactory due to the alternate energy production pathways by switching be...
Injectable 2D-MoS2-integrated Bioadhesive Hydrogel as Photothermal-Derived and Drug-Delivery Implant for Colorectal Cancer Therapy [0.03%]
作为光热源和药物递送植入物用于结直肠癌治疗的可注射的二维二硫化钼集成生物粘性水凝胶
Xiaojun Long,Jiawei Wang,Huijuan Wang et al.
Xiaojun Long et al.
Photothermal therapy (PTT) combined with chemotherapy using hydrogel as a delivery platform is considered a promising strategy for the treatment of advanced colorectal cancer (CRC). However, maintaining the stability of photo-absorbing agen...
Kirill E Zhurenkov,Darren Svirskis,Bronwen Connor et al.
Kirill E Zhurenkov et al.
The human brain is a highly complex organ characterized by intricate neural networks, biochemical signaling, and unique mechanical properties. The soft and dynamic viscoelastic extracellular matrix (ECM) plays a crucial role in supporting d...
Fibrosis Drug Efficacy Assessment Based on Microfluidic Mechanical Property Evaluation of Spheroid Models [0.03%]
基于微流控球状模型机械性能评估的纤维化药物疗效评价
Bolam Kim,Jeong Yeon Kim,Hye Won Kim et al.
Bolam Kim et al.
Fibrotic diseases, such as pulmonary fibrosis, pose significant challenges in both research and treatment. To address the limitations of existing systems, a novel collision-based spheroid mechanical property assessment system is developed. ...
Cascade-Responsive Nanoprodrug Disrupts Immune-Fibroblast Communications for Potentiated Cancer Mechanoimmunotherapy [0.03%]
级联响应型纳米前药破坏免疫-成纤维细胞通讯以增强癌症机免疫治疗
Xin Guan,Yuting Shen,Chongke Zhao et al.
Xin Guan et al.
The abnormal tumor mechanical microenvironment due to specific cancer-associated fibroblasts (CAFs) subset and low tumor immunogenicity caused by inefficient conversion of active chemotherapeutic agents are two key obstacles that impede pat...
Gloria Pizzoli,Marco Gargaro,Giuliana Drava et al.
Gloria Pizzoli et al.
The immune system provides defense against foreign agents that are considered harmful for the organism. Inorganic nanomaterials can be recognized by the immune system as antigens, inducing an immune reaction dependent on the patient's immun...
Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis [0.03%]
用于治疗椎间盘退变的可注射纳米复合水凝胶：对抗氧化应激、线粒体功能障碍和铁死亡
Zhenyu Guo,Xinzhou Wang,Jing Sun et al.
Zhenyu Guo et al.
Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron-dependent form of cell death, is identified as a critic...
A Neuroimmune-Oncology Microphysiological Analysis Platform (NEO-MAP) for Evaluating Astrocytic Scar Formation and Microgliosis in Glioblastoma Microenvironment [0.03%]
用于评估胶质母细胞瘤微环境中星形胶质瘢痕形成和小胶质细胞增生的神经免疫-肿瘤学微型生理分析平台（NEO-MAP）
Yen N Diep,Hee Jung Park,Xiaohui Zhu et al.
Yen N Diep et al.
Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor, characterized by its heterogeneity in cellular components, including reactive astrocytes and microglia. Since neuroimmune responses like astrogliosis and microgliosis...
UCNPs@PVP-Hemin-GOx@CaCO3 Nanoplatform for Ferroptosis Self-Amplification Combined with Calcium Overload [0.03%]
基于UCNPs@PVP-Hemin-GOx@CaCO3纳米平台的铁死亡自放大与钙超载结合疗法
Yuping Xu,Mingming Ren,Runzhi Deng et al.
Yuping Xu et al.
Due to the complexity of the tumor microenvironment (TME), current tumor treatments cannot achieve satisfactory results. A nanocomposite material, UCNPs@PVP-Hemin-GOx@CaCO3 (UPHGC NPs) is developed that responds to the TME and controls rele...
A Self-Priming Pyroptosis-Inducing Agent for Activating Anticancer Immunity [0.03%]
一种自强化的焦亡诱导剂用于激活抗癌免疫能力
Yanjie Li,Hanxin Feng,Huang Yang et al.
Yanjie Li et al.
Pyroptosis, a form of programmed cell death mediated by the gasdermin family, has emerged as a promising strategy for inducing anti-tumor immunity. However, efficiently inducing pyroptosis in tumor cells remains a significant challenge due ...