Engineered Hollow Nanocomplex Combining Photothermal and Antioxidant Strategies for Targeted Tregs Depletion and Potent Immune Activation in Tumor Immunotherapy [0.03%]
工程化的中空纳米复合材料结合光热和抗氧化策略用于肿瘤免疫治疗中的靶向Tregs耗竭和有效免疫激活
Qi Sun,Yuyan Wang,Hetian Ren et al.
Qi Sun et al.
In the tumor immunosuppressive microenvironment (TIME), regulatory T cells (Tregs) critically suppress anticancer immunity, characterized by high expression of glucocorticoid-induced TNF receptor (GITR) expression and sensitivity to reactiv...
A Novel 3D High-Throughput Phenotypic Drug Screening Pipeline to Identify Drugs with Repurposing Potential for the Treatment of Ovarian Cancer [0.03%]
一种新的三维高通量表型药物筛选流程，用于识别具有再利用潜力的卵巢癌治疗药物
Nazanin Karimnia,Amy L Wilson,Brittany R Doran et al.
Nazanin Karimnia et al.
Ovarian cancer (OC) poses a significant clinical challenge due to its high recurrence rates and resistance to standard therapies, particularly in advanced stages where recurrence is common, and treatment is predominantly palliative. Persona...
Functionalized Cerium Oxide Nanoparticles Enhance Penetration into Melanoma Spheroids In Vivo through Angiogenesis [0.03%]
功能化氧化铈纳米颗粒通过促血管生成增强黑色素瘤类器官中的渗透能力
Lu Fu,Joel M Yong,Robyn Yeh et al.
Lu Fu et al.
Angiogenesis is a crucial step in tumor progression, including melanoma, making anti-angiogenic strategies a widely explored treatment approach. However, both innate and acquired resistance to these therapies suggest that this approach may ...
Programable Prodrug Nanomodulator Targets Tumor Redox Homeostasis Imbalance to Amplify Disulfidptosis and Immunogenic Pyroptosis for Breast Tumor Immunotherapy [0.03%]
可编程前药纳米调节器靶向肿瘤氧化还原稳态失衡以放大二硫键凋亡和免疫原性焦亡用于乳腺肿瘤免疫治疗
Ayeskanta Mohanty,Adityanarayan Mohapatra,Woojin Yang et al.
Ayeskanta Mohanty et al.
Despite the great potential of photodynamic therapy (PDT), its success remains compromised by the abnormal redox homeostasis of tumor cells, which supports survival, growth, and resistance to oxidative therapeutic interventions by neutraliz...
Self-Nourishing and Armored Probiotics via Egg-Inspired Encapsulation [0.03%]
受蛋启发的封装技术实现自我营养和 armor型益生菌
Sohyeon Park,Sungwon Jung,Geonhui Lee et al.
Sohyeon Park et al.
The gut microbiota plays an essential role in regulating overall physiology, including metabolism and neurological and immune functions. Therefore, their dysregulation is closely associated with metabolic disorders, such as obesity and diab...
Guannan Zhu,Hong Zhang,Ruoxi Xie et al.
Guannan Zhu et al.
Amyloid beta (Aβ) is the primary early biomarker of Alzheimer's disease (AD), and since an acidic environment promotes Aβ aggregation, acidification plays a crucial role in AD progression. In this study, a novel acid-responsive near-infra...
Tailoring Lipid Nanoparticle with Ex Situ Incorporated Conjugated Oligoelectrolyte for Enhanced mRNA Delivery Efficiency [0.03%]
通过离位掺入共轭寡电解质来优化脂质纳米颗粒以提高mRNA传递效率
Wilson Wee Mia Soh,Esteban Finol,Samuel J W Chan et al.
Wilson Wee Mia Soh et al.
Developing new lipid nanoparticle (LNP) formulations typically involves reconstruction from separate elements followed by rigorous purification steps, contributing to drawn-out drug discovery processes. Membrane-intercalating conjugated oli...
Enhanced cGAS-STING Activation and Immune Response by LPDAM Platform-Based Lapachone-Chemical-Photothermal Synergistic Therapy for Colorectal Cancer [0.03%]
LPDAM平台增强的lapachone化学光热协同疗法对结直肠癌cGAS-STING激活和免疫反应的作用研究
Xiaoyu Pan,Yan Lin,Chunlin Lin et al.
Xiaoyu Pan et al.
The cGAS-STING signaling pathway is a pivotal immune response mechanism that bridges tumor and immune cell interactions. This study describes a multifunctional LPDAM nanoplatform integrating Lapachone, polydopamine (PDA), and Mn2+, which sy...
A Light-Activatable Nitric Oxide Donor for Targeted Glaucoma Therapy with Real-Time Monitoring Capabilities [0.03%]
具有实时监测能力的目标性青光眼疗法的光激活NO供体
Jiamin Liu,Yankun Lu,Yi Tian et al.
Jiamin Liu et al.
Primary open-angle glaucoma (POAG), the most common form of glaucoma, is characterized by a gradual increase in intraocular pressure (IOP). Nitric oxide (NO) donors are promising treatments for POAG, but their effectiveness requires selecti...
On-Demand Removal of Rapid Hemostatic Sponge for Non-Compressible Hemorrhage Through Disrupting Ionic Bonds [0.03%]
通过破坏离子键实现非压缩性出血的止血海绵按需移除
Pengcheng Zhang,Chuan Yu,Zhuofan Hu et al.
Pengcheng Zhang et al.
Self-expanding hemostatic sponge plays an important role in the control of non-compressible hemorrhage in deep wound. After hemostasis is accomplished, the sponge adheres to the wound via blood clots, posing a considerable challenge in woun...