Hydrogel-Based Tumor Tissue Microarchitecture Reshapes Dendritic Cell Metabolic Profile and Functions [0.03%]
水凝胶基肿瘤组织微结构重塑树突状细胞的代谢特性与功能
Brian Chesney Quartey,Jiranuwat Sapudom,Paul Sean Tipay et al.
Brian Chesney Quartey et al.
The extracellular matrix (ECM) plays a pivotal role in immunomodulation, providing structural and biochemical cues that shape immune cell function. In pathological conditions like cancer and chronic inflammation, dysregulated remodeling oft...
Mitochondria-targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain Through Scavenging ROS and Reducing Inflammation [0.03%]
靶向线粒体的双金属团簇纳米酶通过清除ROS和抗炎缓解神经病理性疼痛
Xiaolei Cheng,Tianjiao Xia,Min Han et al.
Xiaolei Cheng et al.
Neuropathic pain is a significant public health concern. Inflammatory mediators and reactive oxygen species (ROS) are recognized as primary contributors to pain perception. In this study, a mitochondria-targeted modification of bimetallic c...
Müller Glial-Derived Small Extracellular Vesicles Mitigate RGC Degeneration by Suppressing Microglial Activation via Cx3cl1-Cx3cr1 Signaling [0.03%]
穆勒氏胶质细胞衍生的小型胞外囊泡通过Cx3cl1-Cx3cr1信号抑制小胶质细胞活化从而减轻RGC变性
Hai-Dong Qian,Xiang-Yuan Song,Guan-Wen He et al.
Hai-Dong Qian et al.
Retinal ganglion cell (RGC) degeneration leads to irreversible blindness. Müller glia (MG) play pivotal roles in retinal homeostasis and disease through paracrine signaling. Small extracellular vesicles (sEVs) are bioactive nanomaterials d...
Multianalyte Nanopore Detection of Alzheimer's Biomarkers: A Label-Free Platform with Improved Sensitivity and Range [0.03%]
阿尔茨海默病生物标志物的多分析纳米孔检测：具有提高灵敏度和范围的无标记平台
Qianshan Liu,Yulin Ouyang,Yunjiao Wang et al.
Qianshan Liu et al.
Due to matrix interference, detection methods for protein biomarkers in body fluids are limited. Commonly used methods often require antibody modification or fluorescent labeling. Furthermore, subtle differences in protein sequences make it...
Membrane-Anchoring and Oxygen-Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy [0.03%]
用于优化癌症免疫治疗的膜锚定和氧气生成介导的纳米超声敏感剂
Qing Zhao,Ye Han,Wushuang Gong et al.
Qing Zhao et al.
Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers to specific subcellular r...
Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy [0.03%]
具有双重保护设计的多孔Fe/Cu纳米反应器用于精准化疗和化学动力学治疗
Xianyu Zhu,Lingli Gao,Yanbo Zheng et al.
Xianyu Zhu et al.
Poor prognosis and chemotherapy response stem from difficulties in precise targeting and the lack of effective synergistic treatments. Nanozymes show promising potential in tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H...
NIR-Propelled Thermosensitive Bowl-Shaped Nanomotors with High Penetration and Targeting for Photoacoustic Imaging Guided Thrombolysis Therapy [0.03%]
具有高穿透性和靶向性的近红外光驱动的热敏碗状纳米电机在光声成像引导下进行溶栓治疗的应用研究
Yina Su,Linjie Huang,Guizhen Xu et al.
Yina Su et al.
Traditional antithrombotic therapeutic strategies encounter challenges including heightened bleeding risks, short circulation times, low targeting ability, and inferior thrombus penetration. Therefore, a novel thrombolysis nanodrug (APBUL) ...
Protein-Interference-Free and Kidney-Targeting NIR Fluorophores for Accurate in Vivo Imaging of H2S2 during Kidney Ferroptosis [0.03%]
用于肾脏铁死亡过程中准确定量H2S2的体内成像的无蛋白干扰和靶向肾脏近红外荧光染料
Zhangkang Lv,Jing Wang,Jinyuan Xu et al.
Zhangkang Lv et al.
High-fidelity kidney function imaging is important for assessing the nephrotoxicity of drugs and diagnosing renal diseases. However, the current challenges in achieving accurate kidney imaging include unspecific signal enhancement due to al...
Unlocking the Untapped Potential of Photoresponsive Dual-Gas Nanomedicine in Glaucoma Therapy [0.03%]
光敏双重气体纳米药物在青光眼治疗中未开发潜能的释放
Jiamin Liu,Yuan Liang,Yi Tian et al.
Jiamin Liu et al.
Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by optic nerve damage often associated with elevated intraocular pressure (IOP). Although gas therapies hold promise for glaucoma treatment, the limitations of ...
Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function [0.03%]
研究Notch信号在卫星细胞表型和功能中作用的人类肌束平台
Torie Broer,Nick Tsintolas,Stewart Hammond et al.
Torie Broer et al.
Notch signaling plays a pivotal role in regulating satellite cell (SC) behavior during skeletal muscle development, homeostasis, and repair. While well-characterized in mouse models, the impact of Notch signaling in human muscle tissues rem...