Blood-Brain Barrier-Penetrating Nanocarriers Enable Microglial-Specific Drug Delivery in Hypothalamic Neuroinflammation [0.03%]
脑渗透纳米载体能够特异性地针对下丘脑神经炎症的小胶质细胞输送药物
Yoon Tae Goo,Vladislav Grigoriev,Tetiana Korzun et al.
Yoon Tae Goo et al.
Hypothalamic inflammation plays a pivotal role in appetite dysregulation across various pathological conditions, including cancer cachexia. However, delivering anti-inflammatory agents to microglia, key mediators of hypothalamic inflammatio...
Development of Akkermansia Muciniphila Membrane-Coated Mesoporous Silica Nanoparticles with a Cerium Oxide Core for Inflammatory Bowel Disease Treatment [0.03%]
开发以氧化铈为核心的阿克曼菌膜包被介孔二氧化硅纳米粒子用于炎症性肠病治疗
Nianhua Zhang,Xu Zhang,Jiulong Li et al.
Nianhua Zhang et al.
While convenient for patient compliance, the efficacy of oral treatments for inflammatory bowel disease (IBD) is often compromised by the dynamic and harsh chemical environment of the gastrointestinal tract, presenting challenges for effect...
Three-Dimensional Dynamic Blood-Brain Barrier Model Incorporating Native Cell Culture Systems Based on Shape Memory Biomaterials [0.03%]
基于形状记忆生物材料的原生细胞培养系统的三维动态血脑屏障模型
Wenjing Ta,Jianxiang Wang,Anqi Zheng et al.
Wenjing Ta et al.
An engineered three-dimensional (3D) dynamic in vitro blood-brain barrier (BBB) model with vascular-like architecture and fluid shear forces is integrated. The model is comprised of a supply pool, fluid transport pump, flow chamber, 3D cell...
Zhetong Liu,Lei Liu,Rong Huang et al.
Zhetong Liu et al.
The assembly of protocells into prototissues represents a significant step forward in mimicking the hierarchical structure and complex functions of biological tissues. This review explores the construction of various protocell models, inclu...
Hydrogel Adhesive Integrated-Microstructured Electrodes for Cuff-Free, Less-Invasive, and Stable Interface for Vagus Nerve Stimulation [0.03%]
用于无袖套、少侵入和稳定的迷走神经刺激的水凝胶粘合剂集成微结构电极
Jae Young Park,Jongcheon Lim,Carl R Russell rd et al.
Jae Young Park et al.
Vagus nerve stimulation (VNS) is a recognized treatment for neurological disorders, yet the surgical procedure carries significant risks. During the process of isolating or cuffing the vagus nerve, there is a danger of damaging the nerve it...
Tri-Layer Citrate-Based Hydroxyapatite Composite Scaffold Promoting Osteogenesis and Gingival Tissue Regeneration for Periodontal Bone Defect Repair [0.03%]
一种促进成骨和牙龈组织再生的三层柠檬酸基羟基磷灰石复合支架用于修复牙周骨缺损
Wei Qiu,Kaiying Zhang,Min Wu et al.
Wei Qiu et al.
Periodontal bone defect (PBD) treatment involving oral soft and hard tissues is complicated and high requirements for regenerated materials. Besides osteogenic effects, the materials are also required to have the function of barrier soft ti...
Donor Optimizing to Boost Type I and Type II Photosensitization for Solid Tumor Therapy [0.03%]
用于固体肿瘤治疗的供体优化以增强I型和II型光动力学疗法
Xingang Liu,Chuang Liu,Min Wu et al.
Xingang Liu et al.
Oxygen-less dependent Type I photosensitizers (PSs) have emerged as a crucial strategy for enhancing photodynamic therapy efficiency in treating hypoxic tumors. However, solid tumors have normoxia regions situated near functional blood vess...
Regenerating Family Protein 3α-Loaded Responsive Hydrogel Accelerates Infected Diabetic Wound Healing [0.03%]
负载再生家族蛋白3α的响应型水凝胶加速糖尿病感染创面愈合
Qingyun Wu,Shenglong Jiang,Jia Liu et al.
Qingyun Wu et al.
Chronic diabetic wounds are characterized by a persistent inflammatory response, severe oxidative stress, and excessive proteolysis, creating an inhibitory microenvironment that impedes tissue regeneration. Recent findings indicate that reg...
Enhanced PDMS Functionalization for Organ-on-a-Chip Platforms Using Ozone and Sulfo-SANPAH: A Simple Approach for Biomimetic Long-Term Cell Cultures [0.03%]
用于芯片器官平台的PDMS增强功能化的方法：使用臭氧和磺基SANPAH进行仿生长期细胞培养的一种简单方法
Mitzi Pérez-Calixto,Cindy Peto-Gutiérrez,Alyssa Shapiro et al.
Mitzi Pérez-Calixto et al.
Surface modification of polydimethylsiloxane (PDMS) for organ-on-a-chip (OOC) systems is fundamental for the success of cell physiological assays. Although UV light is commonly used for this purpose, surface chemical modifications are only ...