Biophysically Optimized Nanofiber-Hydrogel Scaffold Composite Acts as "Bio-Bonsai" for Peripheral Nerve Simulation and Regeneration via Orienting Adipose Derived Stem Cells into Schwann-Like Cell Differentiation [0.03%]
仿生神经引导支架促进脂肪来源干细胞向施万细胞分化及周围神经再生修复的作用研究
Yanrong Qin,Bo Chen,Yubin Hu et al.
Yanrong Qin et al.
Efficient repairment of peripheral nerve injury (PNI) remains a severe clinical challenge worldwide, and recovering the regenerative capability of neurons in peripheral nervous system is hindered by the slow rate and inaccurate direction of...
A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals [0.03%]
一种无线皮层表面植入物 用于诊断并缓解自由活动动物的帕金森病症状
Hongseong Shin,Kyungtae Kim,Jaeseung Lee et al.
Hongseong Shin et al.
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is involved in motor abnormality, primarily arising from the degeneration of dopaminergic neurons. Previous studies have examined the electrotherapeutic effects of...
Nitric Oxide-Mediated Dual-Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant-Associated Infections [0.03%]
用于植入物相关感染的抗细菌和促进骨整合的智能钛植入物涂层的NO介导双功能涂层
Zishuo Hou,Kun Wang,Guming Liu et al.
Zishuo Hou et al.
The balance of antibacterial and osseointegration-promoting properties on titanium (Ti) implants in a simple and efficient manner is crucial for the management of implant-associated infections, a condition that has become a significant glob...
Tissue-Adhesive, Antibacterial, and Antioxidant Hydrogel Sealant for Sealing Colorectal Anastomotic Leakage and Preventing Postoperative Adhesion [0.03%]
用于结直肠吻合口漏密封及术后防粘连的组织黏附、抗菌和抗氧化水凝胶封缝剂
Zhen Wang,Shuang Li,Desheng Qi et al.
Zhen Wang et al.
Surgical treatment of colorectal diseases typically involves excising the diseased portion of the bowel and anastomosing the remaining sections to reestablish continuity. Surgical suturing has limitations in preventing anastomotic leakage a...
Biomimetic Glycosaminoglycan-Analog Hydrogel for Improved Embolization of Aneurysms: Environment-Selective Swelling [0.03%]
一种用于改善动脉瘤栓塞的仿生糖胺聚糖模拟水凝胶：环境选择性溶胀
Sarit S Sivan,Iris Bonshtein,Maria Khoury et al.
Sarit S Sivan et al.
Injectable hydrogels are promising biomaterials for treating aneurysms, life-threatening blood-filled saccular lesions, enabling complete filling of the aneurysm and supporting tissue repair. Yet, the challenge is to enable clinical transla...
Developing Therapeutically Enhanced Extracellular Vesicles for Atherosclerosis Therapy [0.03%]
治疗性增强型细胞外囊泡在动脉粥样硬化治疗中的应用
Neil Patel,Elijah Avery,Yi Huang et al.
Neil Patel et al.
Atherosclerosis is a chronic condition and the leading cause of death worldwide. While statin therapy is the clinical standard, many patients still experience acute cardiovascular events. To develop better therapies, the group previously de...
Mg2+-Loaded Black Phosphorus Nanosheet Protects against Cerebral Ischemic Injury through Anti-Oxidative and Anti-Inflammatory Effects [0.03%]
负载Mg2+的黑磷纳米片通过抗炎和抗氧化作用保护脑缺血损伤
Min Wang,Xinyi Xia,Yaoyao Li et al.
Min Wang et al.
Ischemic stroke is a severe neurological disease, with high morbidity and mortality worldwide. To date, the treatment of ischemic stroke is limited, and its consequent ischemia-reperfusion injury is an important reason for this result. Exce...
Mandibular Implants: A Metamaterial-Based Approach to Reducing Stress Shielding [0.03%]
下颌植入物：一种基于人工周期结构材料的方法降低应力遮挡效应
Jorn-Ids Heins,Bram B J Merema,Joep Kraeima et al.
Jorn-Ids Heins et al.
Biomechanical complications, such as stress shielding, bone resorption, and reconstruction failure, are prevalently associated with solid titanium mandible reconstruction plates. This study evaluates the potential of metamaterial designs wi...
Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro-Inflammatory Macrophage Activation [0.03%]
用于调控促炎性巨噬细胞活化的医用它康酸聚合物微粒的开发
Kaitlyn E Woodworth,Zachary S C S Froom,Natasha D Osborne et al.
Kaitlyn E Woodworth et al.
Itaconate (IA) is an endogenous metabolite and a potent regulator of the innate immune system. It's use in immunomodulatory therapies has faced limitations due to challenges in controlled delivery and requirements of high extracellular conc...
Ultrasound-Guided Functionalized Extracellular Vesicles for Visualized, Controlled, and Efficient Renal Delivery for Enhanced Kidney Repair [0.03%]
声学引导功能化细胞外囊泡用于可视化、可控和高效肾脏递送以增强肾脏修复
Yuhao Chen,Chunjia Sheng,Tuo Xiao et al.
Yuhao Chen et al.
Mesenchymal stem cell-derived extracellular vesicles (EVs) hold great promise for the treatment of acute kidney injury (AKI). However, their efficacy is limited by inefficient delivery. Current studies largely focus on increasing the propor...