Antioxidant and Anti-Senescence Polyvinyl Alcohol-Gallic Acid Supramolecular Hydrogels for Stem Cell Culture [0.03%]
抗氧化和抗衰老的聚乙烯醇-棓酸超分子水凝胶用于干细胞培养
Yiduo Zhou,Matías L Picchio,Yan Nie et al.
Yiduo Zhou et al.
Replicative senescence presents a significant challenge in mesenchymal stem cell (MSC) expansion due to high reactive oxygen species (ROS) levels generated during culture. Elevated ROS levels lead to oxidative stress, cellular damage, and s...
Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Combined with PEG Hydrogel Alleviate Maternal Simulated Birth Injury in a Rat Model [0.03%]
PEG水凝胶联合脂肪来源的间充质干细胞外泌体缓解大鼠模拟分娩伤模型母体损伤
Qing Wang,Yaqin Li,Yue Zhang et al.
Qing Wang et al.
Pelvic organ prolapse (POP) is a common and distressing condition affecting women, particularly those with a history of vaginal delivery. The impact of extracellular vesicles derived from adipose-derived mesenchymal stem cells (ADSC-EVs) on...
pH and Glucose Dual-Responsive Hydrogels Promoted Diabetic Wound Healing by Remodeling the Wound Microenvironment [0.03%]
通过重塑伤口微环境促进糖尿病伤口愈合的pH和葡萄糖双响应性水凝胶疗法研究
Yifan Zhou,Fanjia Dai,Sifang Zhao et al.
Yifan Zhou et al.
The microenvironment of diabetic wounds is complicated and characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and ischemia, making wound restoration and healing extremely challenging. Therefore, functional hyd...
Orally Administered ZnxCeyO2/Se Hydrogel with Effective Antioxidant Activity for Treating Inflammatory Bowel Disease by Inhibiting Ferroptosis [0.03%]
一种口服给药的具有抗氧化活性的ZnxCeyO2/Se水凝胶通过抑制铁死亡治疗炎症性肠病
Lingling Kan,Tongsheng Li,Weinan Zhang et al.
Lingling Kan et al.
Oxidative stress leads to intestinal barrier damage, which induces immune responses to occur and further promotes oxidative stress exacerbating inflammatory bowel disease (IBD). In this work, the multifunctional ZnxCeyO2/Se (ZCSO) nanozyme ...
Organoid-Like Neurovascular Spheroids Promote the Recovery of Hypoxic-Ischemic Skin Flaps Through the Activation of Autophagy [0.03%]
类器官样神经血管球体通过激活自噬促进缺血性皮瓣的恢复
Junjin Jie,Jingyi Ju,Zhenxing Wang et al.
Junjin Jie et al.
Crosstalk between nerves and blood vessels plays a crucial role in flap development, injury repair, and homeostasis maintenance. However, in most flap transplantation strategies, the interactions between nerves and blood vessels have been i...
Fluoroalkane Engineered Magnetic Vectors Unlock the Potential of Gasdermin in Vivo Delivery for Pyroptosis Induced Cancer Therapy [0.03%]
氟代烷烃工程化磁性载体解锁气腺蛋白体外递送诱导细胞焦亡抗肿瘤潜力研究
Yiling Ruan,Yang Liu,Guojun Lei et al.
Yiling Ruan et al.
Pyroptosis, a programmed necrotic cell death mediated by gasdermin, can activate strong immune responses and serve as a potential target for cancer therapy. Nevertheless, the relatively large molecular size and negative surface charge of ga...
Ceria Centre to Enhance Multi-Active and Photothermal Response Janus Patch for Chronic Wound Senescence Inhibition and Repair [0.03%]
用于慢性伤口衰老抑制和修复的具有多活性和光热响应的Janus贴片中的氧化铈中心
Yilin Ding,Zhipeng Sun,Zilin Wu et al.
Yilin Ding et al.
Bacterial infections and complex microenvironments induce cellular oxidative stress and cellular senescence severely affect chronic wound healing. However, the antibacterial effect of most dressings is single, which is only against the woun...
Selenium-Albumin Nanoaccelerator Hydrogel Promotes Wound Healing by Antibacterial, Anti-Inflammatory and Antioxidant along with Inhibits Scar Formation via Downregulating CD36 [0.03%]
硒蛋白纳米加速器水凝胶通过抗菌，抗炎和抗氧化促进伤口愈合并通过下调CD36抑制瘢痕形成
Lulu Zhao,Junyi Wang,Yu Pan et al.
Lulu Zhao et al.
Wounds repairing after skin damage or diabetes remain a vast medical challenge, which often faces infection, inflammation, oxidative stress, and skin scarring. Herein, a multifunctional selenium-albumin nanoaccelerator hydrogel (H-Se NPs-Ge...
Membrane Encapsulated Fe3O4@MnO@cGAMP Nanocatalyst for Cancer Therapy: cGAS-STING Immune Pathway Activation [0.03%]
用于癌症治疗的膜封装Fe3O4@MnO@cGAMP纳米催化剂：cGAS-STING免疫途径激活
Hua Chai,Renpeng Xia,Nan Ouyang et al.
Hua Chai et al.
Reactive oxygen species (ROS) mediated cell damage is one of the most popular and effective ways for cancer therapy. However, overexpressed antioxidant of reduced glutathione (GSH) is always activated in tumor cells, which maintains redox e...
Cell-Free Biomimetic Tracheal Graft via Hybrid 3D Printing for Enhanced Tracheal Reconstruction [0.03%]
基于混合3D打印的仿生气管移植物用于气管重建
Young Su Yu,Sun Hwa Park,Seon Young Choi et al.
Young Su Yu et al.
When the trachea is excessively damaged because of diseases, accidents, or surgery, it is difficult to achieve both mucosal reconstruction and structural stability using current technologies. Here, a biomimetic tracheal graft (BTG) is devel...