Short-Chain Fatty Acids Modulate Anti-ROR1 CAR T-Cell Function and Exhaustion in an Intestinal Adenocarcinoma-on-Chip Model [0.03%]
短链脂肪酸通过肠道腺癌芯片模型调节抗ROR1 CAR-T细胞功能和耗竭
Valentin D Wegner,Adrian Feile,Miriam Alb et al.
Valentin D Wegner et al.
Chimeric antigen receptor (CAR) T-cell therapy represents a promising approach for cancer treatment, with receptor tyrosine kinase-like orphan receptor 1 (ROR1) emerging as a novel target in malignancies. This study investigates how short-c...
Reprogramming Glucose Metabolism of Macrophage for Acute Liver Failure Therapy with Itaconate Lipo-Nanodrug [0.03%]
利用乙酰化脂纳米药物重编程巨噬细胞葡萄糖代谢治疗急性肝衰竭
Chen Qiu,Wei Zhang,Yanan Zhao et al.
Chen Qiu et al.
Acute liver failure (ALF) is a life-threatening disease featuring comprehensive inflammatory response and metabolic disorders in which macrophages exert central roles. A glucose metabolism mediator of macrophages, itaconate, has demonstrate...
Secretome Derived From Mesenchymal Stem Cells Cultured as Monolayer Show Enhanced Bone Regeneration Compared to Secretome From 3D Spheroid - Clues From the Proteome [0.03%]
与三维球体相比，贴壁培养的间充质干细胞衍生的分泌组可增强骨再生-来自蛋白质组的线索
Shalini Raik,Bhavneet Kaur,Saroj Kumar et al.
Shalini Raik et al.
Repair and reconstruction of critical-sized bone defects present a significant challenge due to poor clinical outcomes of conventional bone repair strategies, such as autologous and allogenic bone grafts. The present study underscores the p...
Imine Crosslinked, Injectable, and Self-Healing Fucoidan Hydrogel with Immunomodulatory Properties [0.03%]
一种交联的、可注射的和自修复的具有免疫调节特性的海带硫酸多糖水凝胶
Asma Talib Qureshi,Shajia Afrin,Saad Asim et al.
Asma Talib Qureshi et al.
Biomaterials with inherent anti-inflammatory properties and the ability to foster a pro-regenerative environment hold significant promise for enhancing cell transplantation and tissue regeneration. Fucoidan, a sulfated polysaccharide with w...
Reliable Harvest of Injectable Human Mesenchymal Stem Cell Sheets by Modulating Cell-Substrate Adhesion Strength [0.03%]
通过调节细胞-基底粘附强度可靠收获可注射的人类间充质干细胞片层
Jemin Yeun,Seonghyeon Park,Younseong Song et al.
Jemin Yeun et al.
Cell sheet engineering has emerged as a promising scaffold-free strategy in cell-based therapeutics, preserving essential cell-cell and cell-extracellular matrix (ECM) interactions. To enable minimally invasive delivery, a key challenge rel...
Light-Activatable Hyaluronic Acid-Derivatives Releasing Nitric Oxide and Their Delivery in the Skin [0.03%]
光激活透明质酸衍生物释放一氧化氮及其在皮肤中的传输
Giuseppe Longobardi,Cristina Parisi,Federica Sodano et al.
Giuseppe Longobardi et al.
Hyaluronic acid (HA), renowned for its hydrating properties, penetrates deeper into the skin at a very low molecular weight, promoting cellular repair and reducing inflammation. Nitric oxide (NO), a gaseous mediator with a very relevant rol...
Dendrimer Conjugates with PD-L1-Binding Peptides Enhance In Vivo Antitumor Immune Response [0.03%]
树枝状大分子-PD-L1结合多肽缀合物能够增强抗肿瘤免疫应答
DaWon Kim,Jin Woong Lee,Piper A Rawding et al.
DaWon Kim et al.
Peptides are an emerging class of biologics for cancer immunotherapy; however, their clinical translation is hindered by poor binding kinetics, bioavailability, and short plasma half-life compared to their corresponding antibodies. Nanopart...
Advances of Metal-Based Nanomaterials in the Prevention and Treatment of Oral Infections [0.03%]
金属基纳米材料在口腔感染预防和治疗中的研究进展
Junnan Qi,Chao Si,Haofeng Liu et al.
Junnan Qi et al.
The complicated environment of the oral cavity presents significant challenges to traditional antibacterial approaches, which has driven the exploration of novel therapeutic strategies. Metal-based nanomaterials (MNMs), with diverse antibac...
3D-Printed Hydrogel Patches Embedded with Cu-Modified Liquid Metal Nanoparticles for Accelerated Wound Healing [0.03%]
用于加速伤口愈合的Cu改性液态金属纳米颗粒嵌入式水凝胶补片的3D打印技术
Bo Wang,Xiaohui Shan,Jianye Gao et al.
Bo Wang et al.
Wound healing is significantly challenged by resistant bacterial infections. Gallium-based liquid metal (LM) antibacterial agents show promise due to their non-inducement of resistance, though their efficacy remains limited. Here, we graft ...