Guofeng Liu,Pengcheng Xia,Bokun Li et al.
Guofeng Liu et al.
Tendons exhibit outstanding mechanical performance due to their hierarchical and anisotropic structures. Despite notable progress in mimicking anisotropy, developing biomaterials that simultaneously exhibit high strength, and excellent bioc...
Engineering Antibacterial, Biocompatible, Anti-Oxidant Titanium-Based Implants Using Polyphenols-Chlorhexidine Networks for Bone Regeneration [0.03%]
用于骨再生的抗菌、生物相容性、抗氧化钛基植体的工程化制备：聚酚-氯己定网络体系
Yankai Wang,Biao Hong,Baozang Yin et al.
Yankai Wang et al.
Implant-associated infections leading to osteolysis and implant loosening are an ongoing clinical challenge. Various strategies have been proposed to equip bone implants with antibacterial properties to prevent infection. However, the cytot...
Engineered Prussian Blue-Curcumin Nanozyme with RONS Scavenging Properties for Augmented Reversible Treatment of Cardiac Hypertrophy [0.03%]
一种用于增强心脏肥厚可逆治疗的工程普鲁士蓝-姜黄素纳米酶及其一氧化氮和过氧化物清除性能
Anlin Luo,Jing Tan,Haisong Wang et al.
Anlin Luo et al.
Pathological cardiac hypertrophy, often triggered by the excessive production and accumulation of reactive oxygen and nitrogen species (RONS), may ultimately lead to heart failure. The treatment of myocardial hypertrophy often involves anti...
Glioblastoma Cell Lysate and Adjuvant Nanovaccines via Strategic Vaccination Completely Regress Established Murine Tumors [0.03%]
通过战略性疫苗接种利用胶质母细胞瘤细胞裂解物和佐剂纳米疫苗完全消退小鼠建立的肿瘤
Songsong Zhao,Yanyi Qu,Zhiwei Sun et al.
Songsong Zhao et al.
Tumor vaccines have shown great promise for treating various malignancies; however, glioblastoma (GBM), characterized by its immunosuppressive tumor microenvironment, high heterogeneity, and limited accessibility, has achieved only modest c...
Extracellular Matrix-Mediated Crosslinking of Adhesive Hyaluronic Acid Patch for Treating Volumetric Muscle Injury [0.03%]
用于治疗体积性肌肉损伤的透明质酸粘合补片的细胞外基质介导交联技术
Eun Je Jeon,Soohwan An,Seung Yeop Han et al.
Eun Je Jeon et al.
The treatment of volumetric muscle loss (VML) is challenging owing to the deficiency of appropriate bioscaffolds and ineffective therapeutic outcomes with conventional approaches. Adhesive hydrogels have emerged as potential tools for promo...
Macrophage-Tased Dual-Phase T Cell Immunomodulation to Combat Transplant Rejection [0.03%]
巨噬细胞介导的双重相态T细胞免疫调节对抗移植排斥反应
Wenyuan Wang,Tang Gao,Yihui Wang et al.
Wenyuan Wang et al.
Transplant rejection remains a major challenge, driven primarily by the activation of alloreactive T cells. While enhancement of PD-L1 checkpoint molecules has exhibited potential in inhibiting T cell activity, its efficacy is often hindere...
Drug Delivery Platform Targeting MMP9 in Combination with Photothermal Therapy to Improve Tumor Chemosensitivity [0.03%]
一种药物递送平台结合光热疗法靶向MMP9以提高肿瘤化疗敏感性
Jixian Fu,Chunyu Song,Shan Jiang et al.
Jixian Fu et al.
Tumor chemotherapy insensitivity poses a significant challenge in cancer treatment, with angiogenesis being a key contributing factor. Angiogenesis supplies oxygen and nutrients to tumor cells, thereby impairing treatment outcomes. Based on...
Tri-Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full-Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies [0.03%]
一种分层生物活性皮肤支架，集成生物活性金属有机框架促进感染性糖尿病全层伤口愈合：多面体治疗策略
Ayse Gunyakti Mujtaba,Ayşe Karakeçili,Berna Topuz et al.
Ayse Gunyakti Mujtaba et al.
Chronic infected diabetic wounds are complex and often lead to severe clinical outcomes such as sepsis, gangrene, and amputation. To address these challenges, herein we developed a novel tri-layered scaffold to provide multi-functional ther...
Strategically Designed Mitochondria-Targeting AIEgens for Effective Eradication of Primary and Metastatic Tumors via Synergistic Phototherapy and Induced Immunogenic Cell Death [0.03%]
一种通过协同光动力疗法和诱导免疫原性细胞死亡有效根除原发性和转移性肿瘤的靶向线粒体聚集诱导发光分子的设计战略
Lin Yang,Jiachang Huang,Yanan Liao et al.
Lin Yang et al.
In recent years, photoimmunotherapy has emerged as an innovative modality in antitumor therapy, garnering significant research interest due to its integration of the advantages of both phototherapy and immunotherapy. However, despite extens...
Near Infrared II Laser-Boosted Peroxynitrite Generation Hollow Copper Single Atom Nanozyme for Effective Bacterial Infection Treatment [0.03%]
近红外II激光增强过硝基化单铜原子纳米酶有效抗菌治疗
Wei Tang,Yuan Fang,Linhao Xie et al.
Wei Tang et al.
The peroxynitrite anion (ONOO-) is the product of a specific reaction between nitric oxide (NO) and the superoxide anion (O2 •-), showing great potential for treating multidrug-resistant bacterial infections. However, antibacterial materia...