Multifunctional Fluorescent Probes for Profiling Cys, Hcy, GSH, and SO₂: Illuminating Their Dynamics in Apoptosis and Ferroptosis [0.03%]
用于检测半胱氨酸、同型半胱氨酸、谷胱甘肽和二氧化硫的多功能荧光探针：阐明其在细胞凋亡及铁死亡中的动态变化机制
Guoxing Yin,Ting Yu,Chunhua Lian et al.
Guoxing Yin et al.
The ability to perform simultaneous fluorescence imaging of multiple targets is essential, providing crucial multi-parametric information necessary for understanding complex biological interactions and processes. In this study, TBC, a novel...
A pH/STEAP Cascade-Responsive Nanomedicine with Self-Supplied Peroxide for Precise Chemodynamic Therapy [0.03%]
一种自供过氧化氢的pH/STEAP级联响应型纳米药物用于精准化学动力学治疗
Huilan Cai,Shenghan Chen,Yang Zhu et al.
Huilan Cai et al.
Self-supply of peroxo compounds has been regarded as a promising strategy to enhance Fenton chemistry-based chemodynamic therapy (CDT). However, the inherent selectivity of CDT will be affected after introducing peroxide-supplementing funct...
Targeted Anti-Inflammatory Nanozymes with Pro-Angiogenic Activity for Myocardial Infarction Therapy [0.03%]
具有促血管生成活性的针对炎症的纳米酶用于心肌梗死治疗
Wenling Yang,Xuelian Li,Jie Lei et al.
Wenling Yang et al.
Myocardial infarction (MI) poses a significant threat to human health. Current treatments emphasize early revascularization to restore blood supply to the myocardium, often overlooking the extensive oxidative damage and autophagy dysfunctio...
Bio-Nano Innovations Targeting the Neurovascular Complex for Epilepsy Treatment [0.03%]
针对神经血管复合体的生物纳米创新 epilepsy 治疗方法
Xin Wang,Yanlong Cheng,Zhengzhuo Qi et al.
Xin Wang et al.
Epilepsy is a prevalent chronic neurological disorder characterized by seizures resulting from an imbalance between excitatory and inhibitory neurons. While pharmacotherapy remains the standard treatment, traditional pharmacotherapy faces s...
Systematic Comparison of Commercial Uranyl-Alternative Stains for Negative- and Positive-Staining Transmission Electron Microscopy of Organic Specimens [0.03%]
有机标本负染和薄层透射电子显微镜的商用铀染料替代品的系统比较
Vera M Kissling,Stephanie Eitner,Davide Bottone et al.
Vera M Kissling et al.
Negative- and positive-staining transmission electron microscopy (ns/psTEM) is a cornerstone of research and diagnostics, enabling nanometer-resolution analysis of organic specimens from nanoparticles to cells without requiring costly cryo-...
β-1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery [0.03%]
β-1,3葡聚糖微粒及纳米粒：制备方法及其在免疫调节和靶向给药中的应用
Nate Dowdall,Todd Hoare
Nate Dowdall
Innate immune cells such as macrophages and dendritic cells play major roles in the progression of many cancerous, fibrotic, and autoimmune diseases, often due to environmental cues that skew these cells toward a phenotype that progresses o...
Natural Turmeric-Derived Nanovesicles-Laden Metal-Polyphenol Hydrogel Synergistically Restores Skin Barrier in Atopic Dermatitis via a Dual-Repair Strategy [0.03%]
天然姜黄素衍生的纳米囊泡负载金属-多酚水凝胶通过双重修复策略协同恢复特应性皮炎皮肤屏障功能
Mingzhen Zhong,Tong Liao,Zehan Zeng et al.
Mingzhen Zhong et al.
Skin barrier impairment is critical in the development of atopic dermatitis (AD), increasing vulnerability to external pathogens and disrupting cell metabolism, which leads to inflammatory stress and immune imbalance. In this study, a natur...
Cyclic Enrichment of Urinary Exosomes Using a MOF-on-MOF-Based Asymmetric Impinging Streams Chip for Bladder Cancer Diagnosis and Prognosis Prediction [0.03%]
基于MOF-on-MOF的非对称撞击流芯片增强尿源性外泌体用于膀胱癌诊断及预后预测
Min Liu,Gaihua Jia,Xiangyu Meng et al.
Min Liu et al.
Urinary exosomes are valuable biomarkers for the liquid biopsy of bladder cancer (BCa), carrying critical biomolecules associated with BCa that assist in clinical diagnosis and prognosis prediction. However, the lack of rapid, efficient, an...
Aggregation-Assisted Three-Photon Fluorescence Resonance Energy Transfer Boosts Phosphorescence for Deep-Tissue Time-Resolved Intravital Brain Imaging [0.03%]
聚集增强三光子荧光共振能量转移促进磷光用于深组织脑活体成像
Bingshun Wu,Yifei Li,Lan Liu et al.
Bingshun Wu et al.
Three-photon phosphorescence microscopic bioimaging holds promise for deep-tissue time-resolved brain imaging with high spatial resolution and contrast. However, developing probes with bright phosphorescence and strong second near-infrared ...
Mild Phototherapy Strategies for Preventing Pathogen Infection and Enhancing Cell Proliferation in Diabetic Wound [0.03%]
糖尿病伤口病原体感染的预防及细胞增殖促进的弱光疗策略研究
Mingji Jiang,Renhao Nie,Jing Kang et al.
Mingji Jiang et al.
Excessive inflammation, bacterial infection, and impaired cell proliferation posed significant challenges to diabetic wound healing. There is an urgent need for an effective method that can simultaneously provide antibacterial activity and ...