Physical Encapsulation and Chemotherapy: A Synergistic Hydrogel Strategy for Tumor Suppression [0.03%]
物理封装与化疗相结合：一种协同水凝胶肿瘤抑制策略
Yajie Gong,Weiguang Yuan,Siyu Liu et al.
Yajie Gong et al.
Conventional chemotherapy remains a fundamental strategy for cancer treatment but is often limited by systemic toxicity. To address this challenge, Mix Gel is developed as a hybrid hydrogel combining the biocompatibility of decellularized o...
Dispersed Graphene Nanosheets Enhance Piezoelectricity of Poly (L-lactic acid) Nanofibrous Scaffold to Promote Bone Defect Repair [0.03%]
分散的石墨烯纳米片增强聚乳酸纳米纤维支架的压电性以促进骨缺损修复
Zhichao Feng,Shengming Zhang,Na Ren et al.
Zhichao Feng et al.
The reconstruction of a localized electrical microenvironment at the defect site is considered an effective strategy to promote bone regeneration by mimicking the electrophysiological properties of natural bone tissue. Nano-piezoelectric ma...
Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery [0.03%]
用于体内mRNA递送的不饱和硫醚离子化脂质的理性设计
Eleni Samaridou,Johanna Simon,Moritz Beck-Broichsitter et al.
Eleni Samaridou et al.
Safe and functional delivery of delicate mRNA molecules to target tissues is a crucial step in the development of effective vaccines and therapeutic interventions. Lipid nanoparticles (LNP) are the most clinically advanced delivery vehicles...
Lucia Rossi,Beatrice Auletta,Luigi Sartore et al.
Lucia Rossi et al.
Skeletal muscle (SkM) tissue engineering aims to generate in vitro 3D products that can be implanted in patients to replace or repair damaged muscles. Having a humanized in vitro model able to mimic the interaction between the innervated re...
Polyphenol Conductive Nanozyme-Enhanced Redox Hydrogel Coupled with Vagus Nerve Electrical Stimulation for Diabetic Wound Repair [0.03%]
用于糖尿病伤口修复的聚苯酚导电纳米酶增强型氧化还原水凝胶与迷走神经电刺激相结合技术
Jinhui Ran,Hao Xia,Chubao Liu et al.
Jinhui Ran et al.
Diabetic wound repair is complicated by excessive oxidative reactions, bacterial infection, and persistent inflammation. Nanozyme-incorporated hydrogels have shown potential to facilitate diabetic wound repair. This study developed a polyph...
Fabrication of Janus-adhesion Multifunctional Hydrogel Based on β-cyclodextrin for Wound Dressing [0.03%]
基于β-环糊精的用于伤口敷料的具有Janus粘附性的多功能水凝胶的制备
Juanli Shen,Shiyu Fu,Xiaohong Liu et al.
Juanli Shen et al.
Conventional wound dressings frequently face challenges of insufficient mechanical strength, inadequate adhesion, irregular drug release, and contamination from adherence to extraneous surfaces. These issues can lead to wound contamination ...
Piezoelectric-Triggered Ferroptosis for Cancer Therapy via Cascade-Enhanced Immune Response [0.03%]
基于压电调控铁死亡的级联增强免疫响应抗癌研究
Huijuan Zheng,Huimin Lin,Yun Ke et al.
Huijuan Zheng et al.
Eliciting ferroptotic cell death in tumors has enhanced prospects for cancer therapy because of its proinflammatory properties, which enable damage-associated molecular pattern (DAMP) release and immune response activation. However, the imm...
Biohybrid Vascular Graft Made of Textile-Reinforced Elastin-Like Recombinamers and Its Preservation via Drying Processes [0.03%]
用于制作生物杂交血管移植物的纺织增强型重组类弹性蛋白多肽及其干燥保存方法
Dominic Pascal Andre,Stephan Ruetten,José Carlos Rodríguez-Cabello et al.
Dominic Pascal Andre et al.
Vascular grafts are crucial for treating cardiovascular diseases and providing vascular access for hemodialysis in end-stage renal disease, conditions that affect millions of people globally. To address the persisting clinical need for bett...
Anti-Infective Polyurethane Dressings via Ultrafast Laser Micro/Nanostructuring [0.03%]
基于超快激光微纳结构的抗菌聚氨酯敷料研究进展
Liang Jing,Zexu Zhang,Zongjing Li et al.
Liang Jing et al.
Bacteria-associated wound infections lead to life-threatening complications such as systemic inflammatory response (SIRS) or septic shock. Even though affordable and permeable polyurethane (PU) dressings are widely used in clinical practice...
Dual-Network Hydrogel Loaded With ROS-activated Hydrogen Sulfide Donor to Accelerate Wound Healing and Inhibit Scar Production [0.03%]
负载ROS激活的供氢硫化物的双网络水凝胶促进伤口愈合和抑制瘢痕生成
Ziqiang Zhou,Xuyang Ning,Wenlong Wei et al.
Ziqiang Zhou et al.
The wound healing process consists of four continuous and overlapping stages-hemostasis, inflammation, proliferation, and remodeling-involving a variety of cells, growth factors, and the extracellular matrix. In recent years, growing eviden...