Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration [0.03%]
多层次的混合表面拓扑结构可协调免疫调节、抗菌防御和组织再生
Mohammad Asadi Tokmedash,Jacob Robins,J Scott VanEpps et al.
Mohammad Asadi Tokmedash et al.
Implant-associated complications-including infection, adverse immune responses, and poor tissue integration-pose significant risks to patients, often leading to implant failure, revision surgeries, or chronic disease. Current chemical-based...
Ascorbic Acid Modulates Collagen Properties in Glucocorticoid-Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation [0.03%]
抗坏血酸调节糖皮质激素诱导的骨质疏松症骨胶原性质：化学、机械和生物调控的新见解
Micaila DE Curtis,Yoontae Kim,Rahul Patil et al.
Micaila DE Curtis et al.
Osteoporosis is a prevalent skeletal disorder characterized by decreased bone mass and structural deterioration, leading to an increased risk of fractures. This study focuses on the regulatory role of Vitamin C (ascorbic acid; AA) in the co...
Cell-Membrane-Camouflaged Biomimetic Nanomedicines for Cerebral Ischemia-Reperfusion Injury Treatment [0.03%]
用于治疗脑缺血再灌注损伤的仿生纳米药物细胞膜伪装技术
Yihong Su,Bingcang Huang,Dingsheng Liu et al.
Yihong Su et al.
Cerebral ischemia-reperfusion injury (CIRI) involves complex pathological processes, including multifaceted inflammatory responses and the extensive recruitment of immune cells, ultimately leading to neuronal damage and functional impairmen...
Targeting PIN1 in Pancreatic Tumor Microenvironment with Peptide Amphiphiles Unleashes Immune Checkpoint Therapy [0.03%]
靶向肿瘤微环境的胰腺癌肽两亲分子制剂可解除免疫检查点疗法抑制作用
Yuanyuan Wu,Jianan Guo,Yuwei Zhang et al.
Yuanyuan Wu et al.
Pancreatic cancer (PC) is a highly aggressive malignancy with a dismal 5-year survival rate of only 12%. Currently, no effective therapeutic strategies can improve the prognosis of pancreatic cancer. The activation of quiescent pancreatic s...
Co-Delivery Evodiamine-Porphyrin Nano-Drug to Enhance Photodynamic-Chemo-Immunotherapy for Triple-Negative Breast Cancer Treatment [0.03%]
共输送埃沃迪明-卟啉纳米药物以增强光动力-化疗-免疫治疗三阴性乳腺癌
Qiang Zhou,Kui Wang,Dahong Yang et al.
Qiang Zhou et al.
Immunotherapy is a promising treatment for triple-negative breast cancer (TNBC), but the immunosuppressive tumor microenvironment (TME) compromises its efficacy. Therefore, the nano-drug TPGS@EVO/Ppa (TEP) is designed and prepared to achiev...
Emily B Roloson,Wei-Hung Jung,Stephanie L McNamara et al.
Emily B Roloson et al.
Current biomaterial strategies are typically unable to return skeletal muscle to pre-injury function following damage, resulting in permanent loss of muscle function. Recently, there has been a growing appreciation for the role of matrix vi...
Multifunctional Immunomodulatory Hydrogel With Bacterial Capture Properties, Intelligently Exhibited Viscous or Elastic Properties and On-Demand Removal Properties for the Treatment of Bacterially Infected Irregular Chronic Wound Healing [0.03%]
一种具有捕获细菌功能的多功能智能免疫调节水凝胶，可按需去除且能根据需求在粘性和弹性之间转换治疗不规则慢性伤口感染愈合性质的水凝胶
Jiakang Zhang,Yuhui Zhang,Tao Fu et al.
Jiakang Zhang et al.
Bacterial infections can trigger disturbances in the wound's internal environment and overstimulate the inflammatory stress response, causing the formation of chronic wounds and even tricky complications. However, irregular wounds with intr...
Engineering Bacteria in Hydrogel for Photo-Triggered Metabolic-Regulation AND-Gated Tumor Immunotherapy [0.03%]
基于水凝胶工程菌的光控代谢调节与肿瘤免疫治疗_AND_逻辑门系统
Qiliner Feng,Chen Wang,Si Shi et al.
Qiliner Feng et al.
Tumor cells reprogram the energy metabolism and re-shape the microenvironment to maintain their fast proliferation and metastasis, leading to immunosuppression. Inspired by the design of engineered living materials, in this study, the AND-g...
Repurposing Nano-Dimensions of a Small Phytomolecule, Rhein, Into Nano-Rhein to Unveil Its Efficacy on Hypercalciuria-Induced Nephropathies on a SERS-Based Calcification Profiling Platform [0.03%]
基于SERS的钙化轮廓平台将小植物分子番红花素重新定位为纳米番红花素以揭示其对高钙尿症诱导肾病的有效性研究
Madhukrishnan Murali,Vishnu Priya Murali,Roopasree O Jayarajan et al.
Madhukrishnan Murali et al.
Renal disorders induced by calcium oxalate (CaOx) crystals potentiate a complex pathophysiological landscape devoid of effective pharmacological interventions. Herein, a bioactive herbal compound, rhein, isolated from Cassia fistula Linn is...
Visible Light Induced DLP-Printed Oxygen-Releasing TPMS Scaffolds Mitigate Early Hypoxia in Bone Defects [0.03%]
光固化打印的TPMS结构氧释放支架用于骨缺损修复诱导早期局部供氧作用
Anastasia B Timoshenko,Ali Ghasemkhani,Chanul Kim et al.
Anastasia B Timoshenko et al.
Oxygen deprivation within large or poorly vascularized bone defects remains a key barrier to successful regeneration, especially during the early postimplantation period before vascular ingrowth. Here, the development of COSnPPOD (CaO2-Sili...