Bioinspired Dormant-ATP-Stabilized Biomineral Amorphous Nanoparticles and Saliva-Activated Rapid Mineralization Toward High-Performance Dental Enamel Restoration [0.03%]
受生物启发的休眠型ATP稳定仿生矿化无定形纳米颗粒及唾液活化快速矿化高效修复牙本质敏感性研究
Si-Yi Li,Ying-Jie Zhu,Heng Li et al.
Si-Yi Li et al.
The high stability of storage and high mineralization efficiency are pivotal for the restoration of acid-etched dental enamel, yet these demands are mutually exclusive and difficult to be met. Herein, we propose a bioinspired "dormancy-to-a...
Spatiotemporally Programmed Nanofiber Scaffold for Coordinated Hierarchical Multi-Tissue Regeneration in Pressure Ulcers [0.03%]
用于压力性溃疡的协同分层多组织再生的时空程序纳米纤维支架
Fan Zhang,Xindan Zhang,Hongtao Hu et al.
Fan Zhang et al.
Stage IV pressure ulcers (PUs) represent the most severe form of chronic wounds, involving full-thickness damage to skin, vasculature, nerves, and muscle, and remain difficult to treat due to the need for coordinated multi-tissue regenerati...
Next-Generation Hydrogel Skin Adhesives: From Bioinspired Adhesion Chemistry to Regenerative Wound Interfaces [0.03%]
下一代水凝胶皮肤粘合剂：从仿生粘附化学到再生伤口界面
Eunyeong Moon,Mehret Tesfaye Nake,Jin-Ju Kim et al.
Eunyeong Moon et al.
Hydrogel-based skin adhesives have emerged as promising alternatives to conventional wound-closure methods such as sutures and staples because they can establish conformal contact with soft, irregular, and wet tissue surfaces. Recent advanc...
Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment [0.03%]
星上药物纳米乳液稳定性试验研究报告
Modupe Adebowale,Nguyen Van Duc Long,Philip M Williams et al.
Modupe Adebowale et al.
Space missions require liquid drug formulations that remain physically stable and exhibit predictable release under launch, microgravity, and handling stresses. This study examined melatonin‑loaded nanoemulsions flown on the MAPHEUS‑15 so...
Mechanically Compliant, Precision-Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration [0.03%]
机械顺应性精密多孔脑植入物可减少异物反应并引导再生
Ian Dryg,Le Zhen,Rebecca Darrow et al.
Ian Dryg et al.
Central nervous system (CNS) diseases and injuries might be treated by implanted devices, tissue regenerative scaffolds, or drug delivery platforms. However, inflammatory CNS responses limit these interventions and may worsen outcomes follo...
Shewanella-Augmented Cerium Oxide Nanoclusters With Superior Antioxidant Activity for Enhanced Radioprotection of Intestine [0.03%]
一种新型席万娜增强型纳米二氧化铈簇抗氧化材料及其肠放射保护作用
Haidong Li,Yuanyuan Shi,Weihao An et al.
Haidong Li et al.
Developing oral radioprotectants for radiation-induced gastrointestinal syndrome (RIGS) is hindered by the non-renewable catalytic capacity of conventional antioxidants and the harsh gastrointestinal biological barriers. Herein, we develope...
Wearable OLED-Assisted Photodynamic Cancer Therapy Using Chlorin e6-Loaded Pluronic Nanocapsules as Photosensitizers [0.03%]
用于辅助光动力癌症治疗的负载血红素e6的普朗尼克纳米囊封剂作为光敏剂用于可穿戴OLED治疗
Hyeryeon Oh,Seung Min Jeong,Cheol Hui Park et al.
Hyeryeon Oh et al.
Photodynamic therapy (PDT) is a minimally invasive cancer treatment strategy. Despite numerous studies confirming its potential advantages, the clinical translation of this technique remains limited owing to the impracticality of using conv...
Peptide Coacervates as Dynamic and Interactive Depots for Tetrodotoxin in Long-Acting Local Anesthesia [0.03%]
用于长效局部麻醉的四叠芽毒素动态和交互式储罐肽共聚物
Xing Wang,Jiahao Zhang,Wen Liu et al.
Xing Wang et al.
Hydrophilic small-molecule therapeutics are difficult to encapsulate using conventional depot delivery systems because of their high-water solubility and rapid diffusion. Here we report a drug-interactive peptide coacervate platform for sus...
Lysosome-Targeted D-π-A Near-Infrared Photosensitizer With Dual Type-I/Type-II ROS Generation for Hypoxia-Resilient Photodynamic Tumor Therapy [0.03%]
一种双机制缺氧耐受型近红外光敏剂用于精准光动力治疗
Yongfei Huang,Li Zhang,Zhefeng Fan
Yongfei Huang
Photodynamic therapy (PDT) is a promising minimally invasive antitumor approach, but its clinical efficacy is severely limited by the single Type‑II reaction of conventional photosensitizers (PSs), insufficient subcellular targeting and po...
Hierarchical Collagen Nanofiber Gels Recapitulate a Physiologically Relevant Tumor Stromal Microenvironment [0.03%]
分层次的胶原纳米纤维凝胶再现了生理相关的肿瘤基质微环境
Naoko Sasaki,Tomoyuki Suezawa,Shiro Kitano et al.
Naoko Sasaki et al.
Cancer tissue forms cancer stroma with a high elastic modulus due to increased type I collagen (Col I) production from fibroblasts and cross-linking of Col I fibers. Stiffened cancer stroma acts on cancer cells as a mechanical stress and pr...