HGF/c-Met Axis-Targeted Nanotherapy via GSH-Responsive Polymer Platforms Suppresses Uveal Melanoma Metastasis [0.03%]
基于GSH响应型高分子平台的HGF/c-Met轴靶向纳米治疗抑制脉络膜黑色素瘤转移
Hui Tao,Hanhan Liu,Hanchen Zhang et al.
Hui Tao et al.
Uveal melanoma (UM), a malignant tumor originating within the ocular, characterizes high metastasis and lethality among patients. Cancer stem cells (CSCs) distinguished by the c-Met protein are believed to mediate tumor metastasis in UM. Ho...
Geometric Adjustment of T Cell-Sensitive Nanorobots for Enhanced Stability [0.03%]
基于几何结构调节的T细胞响应型纳米机器人增强稳定性研究
Yoojin Lee,Dahae Kim,Taihyun Kim et al.
Yoojin Lee et al.
Personalized dendritic cell (DC) based vaccines offer promising immunotherapeutic approaches for cancers and infectious diseases by leveraging living DCs to stimulate a patient's immune system through interactions with T cells. However, con...
Advancing Cellular-Specific Delivery: Machine Learning Insights into Lipid Nanoparticles Design and Cellular Tropism [0.03%]
利用机器学习深入研究脂质纳米颗粒设计和细胞嗜性的细胞特异性输送的进展
Belal I Hanafy,Michael J Munson,Ramesh Soundararajan et al.
Belal I Hanafy et al.
Lipid nanoparticles (LNPs) have gained significant attention as effective nucleic acid delivery vehicles. Despite their success, LNPs are predominantly liver-targeted which limits their broader application. To expand the therapeutic potenti...
Construction of Cells-Membrane-Cells Living Complexes for Cartilage Repair by Enhancing the Structural Stability of Fibrous Membranes [0.03%]
通过增强纤维支架的结构稳定性构建细胞-膜-细胞活性复合物修复软骨损伤
Yanru Hu,Lihui Meng,Wenchao Li et al.
Yanru Hu et al.
3D cartilage tissue engineering scaffolds with stable structures are crucial for promoting cartilage tissue growth and repair. However, limited research attention is given to the effects of 3D cells-membrane-cells sandwich-like living compl...
Manipulating ICG J-Aggregation and Disaggregation for Imaging-Guided Cancer Therapy with Self-Reporting Efficiency [0.03%]
用于自我报告效率的影像引导癌症治疗的ICG J型聚集和解散研究
Zhicong Chao,Kun Wu,Jiahui Sun et al.
Zhicong Chao et al.
Integrating imaging guided therapy and therapeutic effect self-reporting would highly benefit clinic applications. J-type aggregates of organic dyes with corresponding photothermal effect have made them popular agents for photoacoustic (PA)...
Carrier-Free Self-Assembled Nanoparticles for Triple-Amplified Tumor Chemodynamic Therapy and Cuproptosis Induction [0.03%]
一种用于肿瘤化学动力学治疗和铜死亡诱导的无载体自组装纳米粒子
Jiamin Cheng,Siyu Chen,Meijuan Geng et al.
Jiamin Cheng et al.
Chemodynamic therapy (CDT) holds great promise in cancer treatment, whereas its efficacy is severely compromised by the low concentration of endogenous hydrogen peroxide(H2O2), insufficient exogenous catalytic ions, and the presence of high...
Pericyte-Assisted Vascular Lumen Organization in a Novel Dynamic Human Blood-Brain Barrier-on-Chip Model [0.03%]
一种新型动态人体血脑屏障芯片模型中的周细胞辅助血管管腔组织作用研究
Vita Guarino,Elisabetta Perrone,Elisa De Luca et al.
Vita Guarino et al.
Organ-on-Chip (OoC) technology provides a powerful platform for neurovascular research, enabling the precise replication of the blood-brain barrier (BBB) microenvironment, including its 3D architecture and the influence of dynamic blood flo...
Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal-Phenolic Networks [0.03%]
聚乙二醇金属酚网络选择性解组装壳封装小细胞外囊泡
Chenyu Wang,Ailifeire Fulati,Kenta Kimura et al.
Chenyu Wang et al.
Small extracellular vesicles (sEVs) are cell-derived particles used for intercellular communication in living organisms that have gained great interest from researchers for their use as drug carriers and diagnostic agents. However, the isol...
Bioinspired 3D-Printed NIR-Responsive MXene-Based Multifunctional Eutectogel Microneedles for Personalized Infected Wound Healing [0.03%]
仿生3D打印近红外响应性MXene基共晶凝胶微针用于个性化感染创面修复
Huan Liu,Aminov Nail,Decheng Meng et al.
Huan Liu et al.
Infected wound healing remains a significant clinical challenge, demanding innovative therapeutic strategies to simultaneously address bacterial elimination, tissue regeneration, and controlled drug delivery. Inspired by the hierarchical st...
Hossein Vojoudi,Masoud Soroush
Hossein Vojoudi
MXenes exhibit remarkable properties, including high electrical conductivity, tunable surface chemistry, outstanding mechanical strength, and notable hydrophilicity. Recent advancements in bio-functionalization have further enhanced these i...