Rod-shaped Polymerized Salicylic Acid Particles Modulate Neutrophil Transendothelial Migration in Acute Inflammation [0.03%]
棒状聚合水杨酸颗粒调节急性炎症中的中性粒细胞迁移穿过内皮屏障
M Valentina Guevara,Emma R Brannon,Daniel Kupor et al.
M Valentina Guevara et al.
Neutrophilic inflammation is present in numerous high-mortality pathologies, including sepsis, deep vein thrombosis, and acute lung injury (ALI). Therefore, regulating neutrophil recruitment becomes an attractive therapeutic approach for ne...
Bioengineering a Patient-Derived Vascularized Lung Tumor-on-Chip Model to Decipher Immunomodulation by the Endothelium [0.03%]
基于患者的含血管肺肿瘤芯片模型的生物工程用于揭示内皮细胞介导的免疫调节作用
Christine Lansche,Ségolène Ladaigue,Giacomo Gropplero et al.
Christine Lansche et al.
The endothelium compartment is a key player in tumor initiation and progression, but most existing tumor-on-chip models lack clinical relevance. Here, a 3D vascularized tumor-on-chip (vToC) model, generated with patient-derived microvascula...
Morphometric-Assisted Prediction of Developmental Toxicity Using Stem Cell-Based Embryo Models in Microwells [0.03%]
基于干细胞的胚胎模型在微孔板中用于发育毒性预测的形态计量学研究
Vinidhra Shankar,Athanasia Zoi Pappa,Clemens van Blitterswijk et al.
Vinidhra Shankar et al.
Congenital abnormalities cause ≈3% of fetal defects and premature deaths in Europe, often due to maternal exposure to toxicants. To mitigate the ethical and logistical challenges of animal studies, stem cell-based models are being explored...
A Wet-Adhesive Hydrogel Patch with Rapid-Adhesion, Anti-Swelling, and Pro-Healing Properties for Sutureless Repair of Dural Tear [0.03%]
一种用于硬脑膜撕裂无创修复的快速粘附、防肿和促愈合水凝胶补丁
Hao Zhou,Yue Fan,Jiajun Huang et al.
Hao Zhou et al.
Dural tears and subsequent cerebrospinal fluid leakage are common and intractable in spinal surgery. However, the existing clinical treatments are still unsatisfactory and the effective closure and repair of dural tears remain a huge challe...
Magnesium Ions Induce Endothelial Cell Differentiation into Tip Cell and Enhance Vascularized Bone Regeneration [0.03%]
镁离子诱导内皮细胞向顶细胞分化并增强血管化骨再生
Liang Wang,Xu Wang,Jicenyuan Wu et al.
Liang Wang et al.
Vascularization has been considered an essential strategy for bone regeneration and can be promoted by magnesium ions (Mg2+). During angiogenesis, the differentiation of endothelial cells (ECs) into tip cell is a critical step since it cont...
Selenide-Driven Reactive Oxygen Species Activation and Fe(II) Regeneration for Enhanced Nanocatalytic Antibacterial Therapeutics [0.03%]
硒驱动的活性氧活化和Fe(II)再生增强纳米催化抗菌治疗
Chenyao Wu,Yanling You,Dehong Yu et al.
Chenyao Wu et al.
Fenton-based nanocatalytic therapy has attracted widespread attention for its high efficiency and safety. Nevertheless, Fe2+ regeneration, as the rate-limiting step of Fenton reaction, hinders the ROS-induced oxidative killing. Herein, a Fe...
Ultrasound-Activated Selenium Nanocarrier: Bactericidal Enhancement and Osseointegration Promotion for Implant-Associated Infections [0.03%]
超声激活硒纳米载体：用于种植体相关感染的杀菌增强和促进骨整合
Zhiying Cao,Renhao Xu,Wenyi Zheng et al.
Zhiying Cao et al.
Implant-associated infections (IAIs) are common and challenging complications of orthopedic surgery. The physical barrier formed by biofilms and the antioxidant defense system of bacteria shield them from attack by antimicrobial agents and ...
Niveen M Khashab,Ying-Wei Yang,Jeremiah J Gassensmith
Niveen M Khashab
Development of DNase-1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation for Neutrophil-Mediated Drug Delivery to In Vitro Thrombi [0.03%]
基于反向闪光纳米沉淀法载DNase-1聚合物纳米粒的中性粒细胞介导的血栓定向给药研究
Sophie Maiocchi,Erica E Burnham,Ana Cartaya et al.
Sophie Maiocchi et al.
Activated neutrophils release Neutrophil Extracellular Traps (NETs), comprising decondensed chromatin, peroxidases, and serine proteases, which aid in host defense but are also implicated in thrombosis and resistance to thrombolysis. Recomb...