Smart Silk-Based In Situ Sol-Gel Modulates Rectal Microenvironment for Effective Ulcerative Colitis Alleviation [0.03%]
基于智能丝蛋白原位溶胶-凝胶调节直肠微环境有效缓解溃疡性结肠炎
Perumal Ramesh Kannan,Liuting Chen,Yudie Lv et al.
Perumal Ramesh Kannan et al.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, with untreated cases often progressing to colorectal cancer. Current treatments aim to induce inflammatory remission but often neglect the surrounding microenvironment, which ...
A Polysaccharide-Based Self-Gelling Powder With Antibacterial and Antioxidant Capacities for Acute Hemostasis and Efficient Infected Wound Healing [0.03%]
一种具有抗菌和抗氧化特性的止血和促伤口愈合的多糖自凝粉
Wei Li,Jiahao Yang,Weishi Kong et al.
Wei Li et al.
Traumatic wounds with severe bleeding and heavy contamination present significant challenges, including delayed healing and high infection rates. An ideal wound dressing should achieve rapid hemostasis, provide antibacterial activity, and r...
Synergistic Provoking of Pyroptosis and STING Pathway by Multifunctional Manganese-Polydopamine Nano-Immunomodulator for Enhanced Renal Cell Carcinoma Immunotherapy [0.03%]
一种多功能锰-聚多巴胺纳米免疫调节剂协同促进焦亡和STING信号通路用于增强肾细胞癌免疫治疗
Yufei Du,Yiyin Mai,Zhiwen Liu et al.
Yufei Du et al.
Manganese ions are known to enhance anti-tumor immunity by activating the cGAS-STING signaling pathway. However, precise modulation of the tumor microenvironment using manganese ions remains a challenge. Dopamine, with its controlled releas...
An All-In-One Dendrobium Ionic Hydrogel with Wound Microenvironment Remodeling for Promoting Diabetic Wound Healing [0.03%]
一种用于促进糖尿病伤口愈合的综合性石斛离子水凝胶（调节伤口微环境）
Beige Zong,Yongquan Lu,Zhongfu Li et al.
Beige Zong et al.
Diabetic wounds pose a complex clinical challenge due to their intricate pathological microenvironment and delayed healing process. To address this challenge, this work has developed a multifunctional all-in-one ionic hydrogel through dynam...
A 3D Co-Culture System Inspired by Fracture Healing Cell Interactions for Bone Tissue Engineering [0.03%]
一种受骨折愈合细胞相互作用启发的三维共培养系统用于骨组织工程
Jicenyuan Wu,Yuxuan Wang,Liang Wang et al.
Jicenyuan Wu et al.
Peri-bone fibroblasts play a crucial role in regulating bone regeneration during early fracture healing. Inspired by the synergy between osteoblasts and fibroblasts at fracture sites, a biomimetic three-dimensional (3D) indirect co-culture ...
A NIR-Responsive Deep Penetration Phototherapy Strategy for Treating Infected Skin Defect via Antibacterial Effect and Inflammation Elimination [0.03%]
一种用于治疗感染性皮肤缺损的近红外响应深层穿透光疗策略：抗菌和消炎作用
Jinze Song,Wenxin Liu,Li Yang et al.
Jinze Song et al.
The increasing severity of antibiotic resistance and the delayed healing of infected wounds have triggered an arduous challenge that threatens human health. Instantly, quiet a few novel, efficient, and safe antibacterial strategies are urge...
NIR-II-Responsive Chainmail Nanocatalysts for Spatiotemporally Controlled Enzymatic Tumor Therapy [0.03%]
时空可控的近红外响应型纳米网状酶催化前药用于肿瘤治疗
Hongji Liu,Zhenxing Wang,Xinyue Hu et al.
Hongji Liu et al.
The clinical translation of metal-based peroxidase-like nanozymes for antitumor therapy faces two critical challenges: off-target catalytic activation and suboptimal hydroxyl radical (•OH) generation efficiency. To address these limitation...
ROS-Responsive Hydrogel Delivering METRNL Enhances Bone Regeneration via Dual Stem Cell Homing and Vasculogenesis Activation [0.03%]
ROS响应性水凝胶递送METRNL通过双重干细胞归巢和内皮细胞激活促进血管发生及骨再生
Yue Xu,Rui Huang,Wodong Shi et al.
Yue Xu et al.
Critical-sized bone defects arising from bone-related diseases pose a clinical challenge, exceeding the body's natural healing capacity. Evidence has shown that a disordered microenvironment characterized by reactive oxygen species (ROS) ov...
Bioinspired Carbon Dots with Multi-Enzyme Activity, Single-Atom Catalytic, High Efficiency ROS Scavenging and Antioxidant Therapy for Rheumatoid Arthritis [0.03%]
具有多酶活性、单原子催化、高效ROS清除和抗氧化疗法的仿生碳点治疗类风湿性关节炎
Qian He,Ruijiao Li,Jiawen Liu et al.
Qian He et al.
Carbon dots (CDs) with enzyme-like activity have garnered significant attention due to their ability to mimic the catalytic functions of natural enzymes, making them suitable for specific biochemical reactions in biological environments. Ho...
Harnessing Aggregation-Induced Emission and Multi-FRET Strategies in a Single Conjugated Polymer Nanosystem for Enhanced Antibacterial Phototheranostics at Minimal Dosage [0.03%]
通过单共轭聚合纳米系统同时利用聚集诱导发光和多福勒共振能量转移策略实现最小剂量下的增强型抗菌光诊疗功能
Chunhong Zhu,Sameer Hussain,Ziyu Yue et al.
Chunhong Zhu et al.
Developing effective antibacterial photosensitizers with excellent fluorescence properties, enhanced reactive oxygen species (ROS) generation, and low dosage requirements is highly desirable but remains a major challenge. Herein, a new aggr...