Nanocatalytic Therapy for Pneumonia by a Hetero-Element-Doped Carbon Nanozyme [0.03%]
异质元素掺杂的碳纳米酶用于肺炎纳米催化治疗
Min Zhou,Minxuan Zhang,Jiayuan Feng et al.
Min Zhou et al.
Pneumonia continues to be complicated by its progression to acute lung injury (ALI). The onset of ALI is linked to an overproduction of reactive oxygen species (ROS) and a severe inflammatory response. Therefore, the rapid mitigation of ROS...
Engineered 3D Kidney Glomerular Microtissues to Model Podocyte-Centric Diseases for the Validation of New Drug Targets [0.03%]
用于验证新药物靶点的以足细胞为中心的肾脏疾病的工程三维肾球囊微组织模型
Sara Buttό,Solange Vidal,Xi Rui Zeng et al.
Sara Buttό et al.
Podocytopathies are a diverse group of kidney diseases characterized by podocyte injury, leading to proteinuria and reduced kidney function. This injury often disrupts cytoskeletal dynamics and cellular adhesion, causing glomerular dysfunct...
Pyrophosphate-Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality [0.03%]
含焦磷酸的钙磷化合物会对异位骨质量产生负面影响
Martina Jolic,Isabella Åberg,Omar Omar et al.
Martina Jolic et al.
In bone, critical size defects pose substantial challenge in maxillofacial and orthopedic reconstructions as they are incapable of spontaneous regeneration. In such cases, autografts, allografts, and bone graft substitutes are used. Calcium...
Mechanics Mediated Semi-Convertible Hydrogel Enabled Sustained Drug Release [0.03%]
力学介导的半互换水凝胶载药体系用于药物长效缓释
Hongyue Jiang,Xing Lu,Tianshi Bu et al.
Hongyue Jiang et al.
The dynamic mechanic environment surrounding the wound may retard wound healing, and even lead to an exacerbation of inflammation and scar. How to actively promote wound healing under a dynamic mechanical environment during human motion is ...
Intracellular In Situ Assembled DNA Networks Targeting Mitochondria Enable Selective Elimination of Senescent Cells and Improve Cell Viability [0.03%]
细胞内原位组装的靶向线粒体DNA网络选择性消除衰老细胞并提高细胞存活率
Zhi-Qi Dai,Sha Lu,Zhen-Tong Shen et al.
Zhi-Qi Dai et al.
Mitochondria play crucial roles in energy production, metabolism regulation, and cell death. Mitochondrial dysfunction is associated with many diseases, including cancers, aging, and neurodegenerative disorders. Consequently, developing met...
Photoimmuno-Lure Nanoplatform for Enhancing T Cell Expansion in Glioblastoma via Synergistic Treatment of Photodynamic Therapy and Immune Checkpoint Inhibition [0.03%]
通过光动力疗法和免疫检查点抑制的协同治疗增强胶质母细胞瘤中T细胞扩增的光免疫吸引纳米平台
Minji Ahn,Yuhyun Na,Hani Choi et al.
Minji Ahn et al.
The immunosuppressive tumor microenvironment (TME) of glioblastoma (GBM) limits the efficacy of immune checkpoint inhibitors (ICI), primarily due to the absence of cytotoxic T (Tc) cells. In this study, a photoimmuno-lure nanoplatform is pr...
Si Microanemones Integrated Microfluidic Chip for Highly Efficient Isolation of Extracellular Vesicles [0.03%]
硅微海葵集成式芯片实验室微流控芯片高效提取细胞外囊泡
Hanyue Kang,Lei Qiu,Yecheng Li et al.
Hanyue Kang et al.
Liquid biopsy has emerged as a transformative approach for early cancer detection and treatment monitoring, offering significant potential to improve patient outcomes. However, isolating tumor-derived extracellular vesicles (EVs) from body ...
Light-Responsive Oxygen Generation from Chlorella Hydrogels for Facial Nerve Injury Recovery: Crosstalk between M1/M2 Macrophages and Schwann Cells [0.03%]
富含小球藻的水凝胶通过光响应产氧促进面神经源损伤修复及微环境调控研究
Guihua Wei,Xi Li,Mengqi Huang et al.
Guihua Wei et al.
Facial nerve injury (FNI), hindered by hypoxic microenvironments limiting Schwann cell (SCs) repair potential, remains a therapeutic challenge. We developed light-responsive Chlorella hydrogels (C-Gel) to modulate oxygen release and inflamm...
Dual-Responsive Immunomodulatory RNAi Nanoplatform for Effective Immune Checkpoint Blockade and Enhanced Cancer Immunotherapy [0.03%]
用于有效免疫检查点封闭和增强癌症免疫治疗的双重响应型免疫调控RNAi纳米平台
Yuan Cao,Zixuan Zhao,Junyue Fang et al.
Yuan Cao et al.
Immune checkpoint blockade (ICB) therapy has become the first-line treatment for cancer patients. However, the low response rate remains a clinical pain-point. Anti-hyperglycemic drug metformin has shown remarkable anticancer effect with th...
Polymer-Conjugated SOD-Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia-Reperfusion Injury During Kidney Transplantation [0.03%]
聚合物结合的SOD-Pt⁰胶束增强ROS级联清除以缓解肾移植缺血-再灌注损伤
Shengzhou Li,Fei Duan,Zhiwen Qiu et al.
Shengzhou Li et al.
Ischemia-reperfusion injury (IRI) during kidney transplantation is linked to oxidative stress induced by excessive reactive oxygen species (ROS), which causes the injury of transplanted kidney, leading to further intensified organ shortages...