Mussel-Inspired Hemostatic Hydrogel Adhesive Formulated from a Gelatin-Oxidized Dextrin Double Network [0.03%]
受贻贝启发的凝血止血水凝胶双网络粘合剂的设计及其作用机理研究
Baokun Liu,Jiming Zhang,Wen Liu et al.
Baokun Liu et al.
Hydrogels are recognized for their excellent biocompatibility and biodegradability, making them promising candidates for hemostatic materials, especially in cases of intra-abdominal bleeding or injury to vital organs. In this study, a musse...
Weibo Zhang,Chong Chen,Ran Wang et al.
Weibo Zhang et al.
Human serum albumin (HSA) plays an indispensable role as a carrier of endogenous and exogenous substances in vivo. The efficiency of endocytosis determines the transport capacity. However, the potential for enhancing the efficiency of HSA e...
Inflammation-Targeted and Antioxidative Poly(Ferulic Acid) Nanoparticles Directly Treat Chronic Nonbacterial Prostatitis via Inhibiting Pyroptosis by Disrupting Nrf2/KEAP1 Multimer Formation and as a Robust Drug Carrier [0.03%]
炎症靶向和抗氧化的聚阿魏酸纳米颗粒通过破坏Nrf2/KEAP1多聚体形成抑制细胞焦亡直接治疗慢性非细菌性前列腺炎并作为稳健药物载体
Bingliang Chen,Liying Wang,Ruihui Xie et al.
Bingliang Chen et al.
Chronic nonbacterial prostatitis (CNP) is challenging to treat due to limited options. This study introduces a new approach using natural ferulic acid-based polymer nanoparticles to target CNP. Ferulic acid (FA) is polymerized into poly(fer...
Mesoporous Fe3O4 Nanoparticles Loaded with IR-820 for Antibacterial Activity via Magnetic Hyperthermia Combined with Photodynamic Therapy [0.03%]
一种用于磁热和光动力联合杀菌的介孔Fe3O4纳米颗粒载IR-820体系
Yuange Li,Song Xue,Hong Sung Min et al.
Yuange Li et al.
The formation of bacterial biofilms presents a major challenge in infection treatments. Antimicrobial photodynamic therapy (aPDT) typically employs photosensitizers to generate reactive oxygen species (ROS) under irradiation, causing oxidat...
Customizable Polymeric Nanoparticle Materials Optimized on Hypoxic Cells Facilitate mRNA Expression in the Lungs In Vivo [0.03%]
可在缺氧细胞上优化的可定制聚合物纳米颗粒材料可促进体内肺部mRNA表达
Palas Balakdas Tiwade,Vincent Fung,Yutian Ma et al.
Palas Balakdas Tiwade et al.
mRNA therapy has shown great potential in treating lung diseases by enabling transient protein expression without permanently altering the genome. Despite advancements, most mRNA delivery systems, such as lipid nanoparticles and polymeric n...
An Osteochondral Tissue-Mimicking Hydrogel-Scaffold Di-Block Patch for Rapid Repair of Focal Load-Bearing Cartilage Lesions [0.03%]
一种仿软骨组织的水凝胶-支架嵌段贴片，用于快速修复局部负重软骨损伤
Ge Zhou,Xiao Geng,Xinguang Wang et al.
Ge Zhou et al.
Load-bearing cartilage lesions are progressive, so focal lesions require rapid repair to support loading; otherwise, they may generate degeneration of a large area of cartilage till worse osteoarthritis occurs. Replacing the focally lesione...
A Novel Aldehyde Scavenging Modification Boosted Pericardium Valve Materials against Calcification [0.03%]
一种新的甲醛清除修饰方法可增强心包瓣膜材料的抗钙化性能
Fei Kong,Jingjing Zhang,Yang Yang et al.
Fei Kong et al.
Calcific aortic valve disease is an inexorably degenerative pathology and a common cause of morbidity and mortality in heart disease. Clinically, it has no effective medical therapy but can be managed with artificial heart valve replacement...
Immunosuppressive Cytokine-Tethered Hydrogel for Treating Rheumatoid Arthritis [0.03%]
治疗类风湿性关节炎的免疫抑制细胞因子栓系水凝胶
Woojin Back,Moonkyoung Jeong,Huyen-Thao Le et al.
Woojin Back et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Current therapies primarily rely on general immune suppression, often leading to suboptimal outcomes and ...
Targeted Reprogramming of TREM2-Positive Macrophages and MRI-Guided Immune Monitoring in Colorectal Cancer Using CSF1R@Mn@MPDA-Antitrem2 Nanoplatform [0.03%]
基于CSF1R@Mn@MPDA-Antitrem2纳米平台的结直肠癌TREM2阳性巨噬细胞再编程及MRI引导下免疫监测研究
Jie Zhao,Ming Li,Qiong Wu et al.
Jie Zhao et al.
Colorectal cancer (CRC) poses a significant therapeutic challenge due to its immunosuppressive tumor microenvironmentl (TME). In this environment, triggering receptors expressed on myeloid cells 2 (TREM2+) tumor-associated macrophages (TAMs...