Multicomponent Peptide-MXene-Hyaluronic Acid Hydrogel as a Conductive Scaffold for Enhanced Fibroblast Proliferation and Migration Under Electrical Stimulation [0.03%]
导电多组分肽-MXene-透明质酸水凝胶敷料促进电气刺激下成纤维细胞增殖和迁移性能研究
Offir Loboda,Dana Cohen-Gerassi,Dor Aaron Goldstein et al.
Offir Loboda et al.
Chronic and acute skin wounds remain a major clinical challenge due to impaired angiogenesis, persistent inflammation, reduced cell proliferation and migration, and a high risk of infection. These pathological conditions highlight the need ...
An Engineered Bacterial Platform Combining Photothermal Ablation with Immunogenic Cell Death and Microenvironment Remodeling for Synergistic Tumor Therapy [0.03%]
一种集光热消融、免疫原性细胞死亡和微环境重塑于一体的协同抗肿瘤工程细菌平台
Pandi Peng,Peiren Wang,Xue Yang et al.
Pandi Peng et al.
Cancer poses a significant burden on human health and has emerged as a pressing global public health issue. Conventional cancer therapies are constrained by poor spatial precision in drug delivery, inadequate immunogenic cell death, and per...
Engineered Injectable Hydrogel Platform for Tailoring the Osteoarthritis Microenvironment [0.03%]
一种用于调节骨关节炎微环境的新型可注射水凝胶平台
Jiaping Wu,Jianbin Shi,Xinyang Luo et al.
Jiaping Wu et al.
Osteoarthritis (OA) represents a self-sustaining degenerative process characterized by maladaptive interactions among the cartilage, bone, and synovium triads, with current palliative treatments falling short of addressing its pathophysiolo...
Solanum nigrum-Derived Carbon Dots Alleviate Tumor Hypoxia to Potentiate Photodynamic Therapy in Esophageal Squamous Cell Carcinoma [0.03%]
番黑果番茄衍生的碳点通过缓解肿瘤缺氧增强食管鳞癌光动力疗法
Sheng-Nan Luo,Guang-Song Zheng,Jun Jin et al.
Sheng-Nan Luo et al.
Esophageal squamous cell carcinoma (ESCC) is highly prevalent and aggressive in China, with conventional therapies causing significant morbidity. Photodynamic therapy (PDT) kills tumor cells via photosensitizer-mediated reactive oxygen spec...
Xiangzhou Li,Wenjing Xie,Xinyu Jin et al.
Xiangzhou Li et al.
Manganese-ion-based nanoparticles have emerged as highly versatile platforms that seamlessly integrate diagnostic and therapeutic functions, enabling precision cancer theranostics. In this review, we discuss manganese-based nanomaterials th...
Engineering Concentration-Dependent Intravitreal Mobility via Cyclic Arginine-Enriched Nanocarrier Surface Modification: In Vivo Proof-of-Concept in a Porcine Large Animal Model [0.03%]
通过环状精氨酸富集的纳米载体表面修饰调节工程浓度依赖性玻璃体内流动性：猪大动物模型中的概念验证研究
Maximilian Hammer,Bryan Calder Ackermann,Anna Stoß et al.
Maximilian Hammer et al.
Nanoparticulate drug delivery systems represent a promising platform for sustained intraocular drug release following intravitreal administration, leveraging low metabolic turnover of the vitreous to maintain therapeutic drug levels over ex...
An Efficient Biosafe Bioresorbable Hemostatic Nonwoven Gauze From Protonated Carboxymethyl Cellulose [0.03%]
一种高效的生物安全可降解止血非织造布敷料：质子化羧甲基纤维素非织造布敷料
Junhong Wu,Zongxuan Huang,Miaomiao Jiang et al.
Junhong Wu et al.
Currently bioresorbable oxidized regenerated cellulose (ORC) gauze faces significant challenges in terms of harsh manufacture conditions and high cost. To address these issues, we prepared a novel cellulose-based bioresorbable gauze compose...
Molecular Engineering of AIE Photosensitizers for Enhanced Antitumor Phototheranostics [0.03%]
分子工程学在AIE光敏剂中的应用及增强抗肿瘤光疗诊断学的效果
Yin Li,Dong He,Luyao Liu et al.
Yin Li et al.
Cancer remains a major threat to global public health, highlighting the urgent need for precise and effective treatment strategies. Photothermal therapy (PTT) has gained increasing attention as a promising alternative owing to its non-invas...
Programming the Diabetic-Infected Wound Microenvironment With a Smart Hydrogel for Ordered Healing Cascade Restoration [0.03%]
用于糖尿病感染性伤口微环境编程的智能水凝胶，以恢复有序的愈合级联反应
Aihong Chen,Xiaoran Liu,Xiaoqiang Wang et al.
Aihong Chen et al.
The diabetic-infected wound microenvironment, marked by elevated reactive oxygen species (ROS) levels, ongoing inflammation, and defective angiogenesis, interferes with the normal wound healing cascade and contributes to delayed and treatme...