Engineering Resatorvid-Loaded Sub-Microgels of Epigallocatechin-3-gallate/Hyaluronic Acid to Treat Acute Lung Injury [0.03%]
负载儿茶素/透明质酸亚微凝胶的制备及其治疗急性肺损伤的效果研究
Bo Liu,Olawale Alimi Alimi,Benjamin Stearnes et al.
Bo Liu et al.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain life-threatening conditions with high morbidity and mortality, largely due to excessive reactive oxygen species (ROS) generation and uncontrolled inflammatory cas...
Glutathione-Triggered Nanodrug Disassembly for Enhanced Combined Ferroptosis and Photodynamic-Chemotherapy of Tumors [0.03%]
谷胱甘肽触发的纳米药物解组装增强肿瘤铁死亡和光动力化学综合治疗效应
Anna Wang,Jingwen Xue,Keying Cai et al.
Anna Wang et al.
Cancer treatment remains challenging due to tumor heterogeneity, drug resistance, and the complex microenvironment that limits monotherapy efficacy. Herein, we report a glutathione (GSH)-responsive multifunctional nanodrug FeCe6@SKN that is...
Engineered Microglial Exosome-Liposome Hybrid Nanovesicles for Synergistic Therapy of Hypoxic-Ischemic Encephalopathy by Dual-Targeting Ferroptosis and Neuroinflammation [0.03%]
工程化的小胶质细胞外泌体-脂质体杂合纳米囊泡通过双重靶向铁死亡和神经炎症协同治疗缺氧缺血性脑病
Chanyue Wang,Kangqian Tian,Changfeng Jia et al.
Chanyue Wang et al.
Hypoxic-ischemic encephalopathy (HIE) is a major cause of neurological injury in neonates, with pathological cascades such as neuroinflammation and ferroptosis driving disease progression. Current therapeutic strategies for HIE are largely ...
The Uric Acid Degrading Probiotics MC1 in Quercetin Nanocoatings and Bioactive Polysaccharides Microgels for Anti-Hyperuricemia and Gut Microenvironment Modulation [0.03%]
檞皮素纳米涂层与益生菌MC1复合微凝胶抗高尿酸血症及调节肠道微环境的研究
Zekun Li,Zhaoxiang Ma,Dongyu Zhao et al.
Zekun Li et al.
Hyperuricemia (HUA), a metabolic disorder associated with inflammatory and gut microbiota dysbiosis, demands effective intestinal-targeted therapies. Herein, a novel intestinal-targeted delivery system was designed based on quercetin nanoro...
Negative Electrets Directed Fibrinogen Assembly for Surface Enrichment of Platelets [0.03%]
负电荷驻极体导向的纤维蛋白原组装用于血小板富集表面
Zhong Wang,Yuji Liu,Hao Geng et al.
Zhong Wang et al.
Platelet-encapsulated growth factors are desired for rapid tissue healing and personalized regeneration; however, guided platelet enrichment on implantable biomaterial surfaces still faces challenges, undermining the clinical effects of com...
Natural Spirulina Platensis Dressing Promotes Diabetic Wound Repair via Mitigating Inflammation, Clearing Advanced Glycation End Products, and Stimulating Angiogenesis [0.03%]
天然螺旋藻提取物促进糖尿病伤口愈合的机制研究
Yangzi Yang,Shasha Liu,Lin Sun et al.
Yangzi Yang et al.
Chronic nonhealing wounds pose a significant and growing global healthcare burden, particularly in the diabetic population, where impaired healing often leads to severe complications like ulceration and amputation. The pathophysiology is mu...
Mapping Nanoscale Protein-Corona Kinetics of DoE-Optimized Perfluorocarbon Encapsulated-PLGA Nanoparticles by In Situ, Time-Resolved Synchrotron SAXS [0.03%]
采用同步辐射时间分辨小角X射线散射原位表征DOE优化的全氟碳封装PLGA纳米颗粒的纳观蛋白冠动力学行为
Joice Maria Joseph,Maria Rosa Gigliobianco,Cristina Minnelli et al.
Joice Maria Joseph et al.
Integrated frameworks that couple statistically guided formulation with nanoscale, time-resolved mapping of the protein corona (PC) remain rare for perfluoro-15-crown-5-ether-loaded poly(lactic-co-glycolic acid) nanoparticles (PFCE-PLGA NPs...
A Physiological Microfluidic Blood-Brain-Barrier Model for In Vitro Study of Nanoparticle Trafficking and Accumulation [0.03%]
一种用于体外研究纳米颗粒转运和积累的生理微流控血液屏障模型
Bryan B Nguyen,Neona M Lowe,Sophia Kellogg et al.
Bryan B Nguyen et al.
Although the blood-brain barrier (BBB) restricts passage of most molecules, various naturally occurring and synthetic nanoparticles (NPs) are nonetheless found within the brain parenchyma. To study the mechanisms underlying this phenomenon,...
A 3D-Printed Compact Multi-Nozzle Microfluidic Device for Scalable Microencapsulation of Pluripotent Stem Cells [0.03%]
一种用于多能干细胞规模化微胶囊化的紧凑型多喷嘴微流控设备
Quoc Huynh Nguyen,Kianna Nguyen,Quang Tuan Che et al.
Quoc Huynh Nguyen et al.
Encapsulation of human pluripotent stem cells (hPSC) has high relevance for biomedical applications ranging from tissue engineering to drug screening and cellular therapies. Microcapsules serve a multitude of purposes-from promoting hPSC or...
A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer-Associated Fibroblasts in Prostate Cancer Metastasis [0.03%]
超疏水三维细胞培养系统揭示癌症相关成纤维细胞在前列腺癌转移中的力学生物学作用
Alexandria T Carter,Abigail R Fabiano,Ehsan Aalaei et al.
Alexandria T Carter et al.
The ability to model metastatic dissemination under physiologically relevant mechanical conditions, especially of aggregated circulating tumor cells (CTCs), remains a challenge in cancer research. To address this need, this work presents th...