Degradable Nanoregulators Based on Ultra-Small Ferrous Sulfide for Photoacoustic/Magnetic Resonance Imaging-Guided Tumor Starvation and Ferroptosis [0.03%]
基于超小硫化亚铁的降解型纳米调控剂用于光声/磁共振成像引导的肿瘤饥饿及铁死亡疗法
Jingjing Wang,Rui Zhang,Shen Gao et al.
Jingjing Wang et al.
Malignant tumors pose a great threat to human health due to their abnormal vascular system and high interstitial density, leading to high invasiveness and low curability. Tumor vasodilation and ensuring deep drug delivery are essential to e...
Biomimetic Nanodrug Prepared by Cell Exocytosis Induces Cancer Stem Cell Differentiation by Attenuating Wnt Signaling Pathway [0.03%]
基于细胞出胞作用的类细胞纳米药物通过抑制Wnt信号通路诱导癌症干细胞分化
Juncai Zhang,Jinchao Zhang,Leyao Kang et al.
Juncai Zhang et al.
Cancer stem cells (CSCs) represent a critical therapeutic target due to their role in chemoresistance and tumor recurrence. Targeting CSCs based on their distinct differentiation ability is a brilliant cancer therapeutic strategy. Although ...
Flexible Electronics-Driven Intelligent Oral Healthcare Paradigms and Next-Generation Preventive Diagnostics [0.03%]
柔性电子驱动的智能口腔医疗模式及下一代预防性诊断技术
Hongwei Sheng,Jinkun Hu,Qing Yue et al.
Hongwei Sheng et al.
Oral health is a vital component of systemic well-being, with neglected conditions potentially triggering broader physiological complications. Current challenges in dental care, including high patient-to-dentist ratios and costly treatments...
Multimaterial and Multidimensional Bioprinting in Regenerative Medicine: Advances, Limitations, and Future Directions [0.03%]
用于再生医学的多材料和多维度生物打印：进展、局限性及未来方向
Zhiruo Yuan,Xiaoqiang Bai,Sida Li et al.
Zhiruo Yuan et al.
3D bioprinting has been advanced from creating simple, static structures with single materials to sophisticated multimaterial and multidimensional designs. This evolution has improved printing precision, the range of application and dynamic...
A Photo-Driven Immune Modulator Combined with Chemo-Photothermal Therapy Blocks Immune Checkpoint for Helicobacter pylori Infection [0.03%]
一种用于治疗幽门螺杆菌感染的基于光控调控免疫调节剂的化疗和光热结合疗法
Jie Li,Xianhui Song,Siyuan Huang et al.
Jie Li et al.
Accumulating scientific evidence has established a strong etiological association between Helicobacter pylori infection and the pathogenesis of gastric disorders. Clinical antibiotic therapy for this microorganism is significantly constrain...
Ternary Copolymers Incorporating Tunable Conjugated Donors for Near-Infrared II Fluorescence Imaging and Photothermal Therapy [0.03%]
用于近红外二区荧光成像和光热治疗的可调共轭给体的三元共聚物
Qiang Qi,Zhongxiu Jiang,Jianqing Li et al.
Qiang Qi et al.
The near-infrared second window (NIR-II) offers excellent spatial resolution and tissue penetration, drawing attention to NIR-II laser-excited photothermal therapy (PTT) and NIR-II fluorescence imaging. However, integrating these two applic...
Generalizing Gelatin Methacryloyl Granular Hydrogel Fabrication Using Stable Microgels with Predictable Stiffness [0.03%]
具有可预测刚度的稳定微凝胶的通用明胶甲基丙烯酰胺颗粒水凝胶制造方法
Yuanhui Xiang,Zaman Ataie,Angie Castro et al.
Yuanhui Xiang et al.
Gelatin methacryloyl (GelMA) granular hydrogel scaffolds (GHS) outperform their bulk, nanoporous hydrogel counterparts in regenerative engineering as a result of cell-scale tunable interconnected void spaces among assembled microgel buildin...
Advanced Multipurpose Spectroscopic Nanobio-Device for Concurrent Lab-on-a-Chip Label-Free Separation and Detection of Extracellular Vesicles as Key-Biomarkers for Point-of-Care Cardiovascular Disease Diagnostics [0.03%]
用于心血管疾病即时检验诊断的外泌体关键生物标志物联合芯片实验室无标签分离检测的多功能光谱纳米生物器件
Emma Buchan,Jonathan James Stanley Rickard,Mark Robert Thomas et al.
Emma Buchan et al.
The global aging population presents a major public health challenge, with cardiovascular diseases (CVDs) remaining the leading cause of death worldwide. Often asymptomatic in early-stages, CVDs are frequently undiagnosed until critical eve...
Manganese-Based Biofunctional 2D Nanosheets Enabled In Situ Macrophage Engineering for Precise Eradication of Osteomyelitis [0.03%]
基于锰的生物功能二维纳米片原位工程化巨噬细胞精准根除骨髓炎
Shengchang Zhang,Huaijuan Zhou,Bowen Chi et al.
Shengchang Zhang et al.
Efficient treatment of osteomyelitis caused by Staphylococcus aureus is a great clinical challenge due to bacterial resistance and immune evasion issues. Macrophages play a crucial role in the fight against S. aureus but suffer from deficie...
Lysozyme Fiber-Inspired Versatile Supramolecular Hydrogel Against Drug-Resistant Pathogens and Biofilm Formation [0.03%]
一种抗耐药病原体及生物膜形成的类溶菌酶纤维多功能超分子水凝胶
Xirui Long,Yuanyuan He,Ao Wang et al.
Xirui Long et al.
Multidrug-resistant (MDR) bacterial infections pose a significant threat to human health, particularly when introduced by surgical contamination, resulting in early-stage implant-related biofilm infections and potential implant failure. Ins...