Dual-Switchable Nanoparticles Resolving the Safety-Efficacy Paradox of Sonodynamic Immunotherapy for Hepatocellular Carcinoma [0.03%]
一种声动力免疫治疗肝癌的双重可切换型纳米颗粒及其缓解疗效与安全性的矛盾关系研究
Xiujun Gao,Yao Wang,Mingyuan Wang et al.
Xiujun Gao et al.
Clinical translation of sonodynamic therapy for hepatocellular carcinoma is limited by a safety-efficacy paradox: sonosensitizer activation in healthy tissues poses risks, while tumor efficacy is constrained by hypoxia and redundant antioxi...
A Fully Defined GelMA-Based Matrix Allows Fine Tuning of Tissue-Relevant Biomechanical and Biochemical Cues for Organoid Culture [0.03%]
一种全新的明胶美(MA)基质完全不含外来物质，适用于类器官培养，并可精确调节组织相关生物力学和生物化学信号
Junyi Liu,Su Su Htwe,Lay Poh Tan et al.
Junyi Liu et al.
Organoids are powerful models for developmental biology, disease modelling, and personalized medicine. However, their broader application is limited by the inability of extracellular matrix (ECM) hydrogels to mimic the biomechanical and bio...
A Multifunctional Nanozyme-Based mRNA Delivery Platform Restores Neurovascular and Sudomotor Function in Diabetic Neuropathy [0.03%]
一种多功能纳米酶mRNA递送平台可恢复糖尿病神经病变的神经血管和汗液分泌功能
Xu Guo,Kangli Guo,Chao Zhang et al.
Xu Guo et al.
Diabetic sudomotor dysfunction, one of the most prevalent complications of diabetic neuropathy (DN), is characterized by impaired sweating due to degenerative changes in sweat glands (SGs) and associated neurovascular networks. Despite its ...
Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment [0.03%]
肺癌治疗中纳米材料在免疫疗法肺递送的策略研究
Han Zhang,Wei Tang
Han Zhang
Organ-selective immunomodulation is increasingly viewed as a route to improve the therapeutic index of cancer immunotherapy, yet most agents are still delivered systemically, where limited tumor exposure and immune-related toxicities remain...
Injectable Supramolecular Hydrogel Encapsulating CRISPR-Engineered MSCs Drives Synergistic Neuroprotection and Functional Recovery After Traumatic Brain Injury [0.03%]
负载CRISPR工程间充质干细胞的可注射超分子水凝胶促进创伤性脑损伤后的协同神经保护和功能恢复
Chao Xu,Yi Liu,Mengge Wang et al.
Chao Xu et al.
Traumatic brain injury (TBI) triggers complex secondary pathologies that lack effective treatments. While mesenchymal stem cell (MSC) transplantation is promising, it is severely limited by poor cell retention and survival. To address these...
Inflammation-Responsive Nanocolloidal Hydrogel Enables On-Demand Gene Activation for Osteoarthritis Therapy [0.03%]
炎症响应纳米胶体水凝胶用于骨关节炎治疗的按需基因激活
Yuexin Zhao,Yang Song,Yuling Shen et al.
Yuexin Zhao et al.
Synovitis-driven inflammation and oxidative stress are key drivers of osteoarthritis (OA) progression. As a master regulator of antioxidant and anti-inflammatory defenses, nuclear factor erythroid 2-related factor 2 (Nrf2) represents a prom...
Selective Blood Cell Hitchhiking in Whole Blood With Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection [0.03%]
具有离子液体包被的PLGA纳米粒在全血中选择性地“搭便车”以改变静脉注射后的体内分布行为
Christine M Hamadani,Duoyi Hu,Gaya S Dasanayake et al.
Christine M Hamadani et al.
Nanoparticles (NPs) are great for systemic drug delivery because they can encapsulate diverse therapeutics, protect cargo from degradation, and enable controlled release profiles. Their performance, however, strongly depends on the ability ...
Large Language Model-Driven Throat-Wearable Sensing System for Real-Time Recognition and Evaluation of Swallowing Disorders [0.03%]
基于大语言模型的咽喉穿戴式实时吞咽障碍感知与评估系统
Zitang Yuan,Yihan Lin,Xiyao Zhao et al.
Zitang Yuan et al.
Swallowing disorders are a common complication after stroke, yet current assessment methods rely largely on clinical observation and subjective screening, limiting continuous and objective evaluation. Here, we report a large language model ...
Mesoporous Silica-Confined Ruthenium Nanozyme Motors Reprogram Redox-Inflammatory Crosstalk to Suppress Atherosclerosis via NRF2 Nuclear Translocation [0.03%]
限域在介孔二氧化硅中的钌纳米酶电机通过NRF2核转位重新编程氧化炎症交叉对话以抑制动脉粥样硬化
Hao Tang,Lu Chen,Junyue Xing et al.
Hao Tang et al.
Elevated intravascular reactive oxygen species (ROS) and persistent inflammation are defining characteristics of the atherosclerotic microenvironment, making their simultaneous modulation a pivotal challenge in cardiovascular therapy. In re...
Gradient Zinc-Doping Strategy Combined With Tumor Metabolic Interference for Effective Catalytic Immunotherapy [0.03%]
结合肿瘤代谢干扰的梯度锌掺杂策略用于有效的催化免疫治疗
Chang Liu,Jing Wang,Weili Xue et al.
Chang Liu et al.
Photocatalytic immunotherapy has attracted significant attention due to high selectivity and low side effects. However, the poor tissue penetration of ultraviolet-visible light and the low energy of near-infrared (NIR) photons, combined wit...