Hyperbranched Polylysine-Based Lipopolyplexes Enable Efficient mRNA Delivery With Long-Term Storage Stability [0.03%]
基于 hyperbranched 聚 lysine 的脂质聚复合物可实现高效 mRNA 传递并具有长期储存稳定性
Huidi Meng,Bingjie Fu,Min Liang et al.
Huidi Meng et al.
Clinical translation of messenger RNA (mRNA) therapeutics is often hampered by the poor storage stability of lipid-based delivery vectors. Many lipopolyplex (LPP) delivery systems struggle to achieve efficient nucleic acid release through t...
Bioinspired All-in-One Wound Dressing: Integrating Photothermal-Enhanced Drainage and Strain-Sensing Monitoring for Intelligent Healing [0.03%]
智能伤口愈合仿生多功能敷料：光热增强引流与应变监测
Zhihua Liu,Naiqian Zhang,Tianjia Jiang et al.
Zhihua Liu et al.
The effective management of chronically infected wounds faces numerous challenges, with the core difficulty lying in achieving efficient liquid drainage and continuous antibacterial effects. Inspired by the asymmetric wetting property of Pi...
A γ-Ray-Responsive Dynamic Covalent Polymeric Radioprotectant for Efficient Radiation Injury Treatment [0.03%]
一种高效治疗辐射损伤的γ射线响应型动态共价聚合物放射防护材料
Yingyi Ning,Xiaoxue Hou,Chaoyi Lyu et al.
Yingyi Ning et al.
The increasing risk of radiation exposure has intensified the demand for advanced radioprotective strategies to counteract radiation injury. Here, a γ-ray-responsive dynamic covalent polymeric radioprotectant, engineered by integrating phe...
Engineering Advanced Nanomedicine Against Depression: From Treatment Challenges to Delivery Strategies [0.03%]
工程化高级纳米药物治疗抑郁症：从挑战到递送策略
Mijia Zhang,Enyao He,Youlan Xiong et al.
Mijia Zhang et al.
Depression is a leading global health burden, yet current pharmacotherapy remains constrained by depression-specific challenges that extend beyond simple blood-brain barrier (BBB) penetration, including delayed onset of action, poor regiona...
Multifunctional Thiolated Hyaluronic Acid-graft-PEDOT Dressing With Antifouling, On-Demand Drug Delivery and Electrical Stimulation for Wound Healing [0.03%]
具有防污，按需药物输送和电刺激功能的透明质酸接枝PEDOT敷料促进伤口愈合
Jingwen Yang,Jiwon Hong,Anthony Phillips et al.
Jingwen Yang et al.
Recent advances in electro-responsive wound dressings have enabled on-demand drug delivery or electrical stimulation (ES) to accelerate healing; however, integrating both functions within a single platform remains challenging. Here, we repo...
A Hierarchical Hydrogel Modulates Immune-Mechanical Microenvironments to Spatiotemporally Reprogram Fibroblasts for Scarless Diabetic Wound Healing [0.03%]
分级水凝胶通过调节免疫-力学微环境实现时空重塑成纤维细胞促进糖尿病伤口无瘢痕修复
Shuangli Zhu,Qiuyue Ma,Ayang Zhao et al.
Shuangli Zhu et al.
Fibrosis remains a major challenge in wound repair due to the dual role of fibroblast in tissue regeneration and fibrotic deposition. Early fibroblast activation supports wound closure, whereas sustained activation during remodeling drives ...
An Intelligent Spatially Selective Modified Starch Hydrogel Dressing Breaks the Stability-Efficiency Trade-Off in Bioactive Delivery [0.03%]
一种智能型空间选择性改良淀粉水凝胶敷料打破生物活性物质递送的稳定性与有效性折中trade-off效应
Xiaolu Liu,Zhenyu Hu,Xu Fei et al.
Xiaolu Liu et al.
Intelligent controllable-release hydrogel systems hold significant promise for wound management, owing to their capacity for on-demand and precise drug delivery. Nevertheless, existing delivery systems encounter substantial challenges in en...
Smart Immunomodulating Nanocomposites Enabling on-Demand Solid Tumor Treatment With Quasi-Real-Time Response Monitoring [0.03%]
一种智能免疫调节纳米复合材料用于实体肿瘤的按需治疗及准实时响应监测
Andreia P Magalhães,Lara Diego-González,Cátia D F Martins et al.
Andreia P Magalhães et al.
Recent advances in cancer immunotherapy face challenges such as limited efficacy in solid tumors, adverse effects, and prohibitive costs. This study addresses these challenges by developing a theranostic magnetic nanocomposite (mNC) system ...
Antioxidant MOF Nanozyme-Engineered Periodontal Ligament Stem Cells Promote Diabetic Wound Healing [0.03%]
抗氧化MOF纳米酶工程化牙周膜干细胞促进糖尿病伤口愈合
Xinjuan Liu,Qing Dong,Yuhui Sun et al.
Xinjuan Liu et al.
Diabetic chronic wounds, as a prevalent and serious complication of diabetes, pose serious threats to patient health and survival, underscoring the urgent need for effective therapeutic strategies. Stem cell therapy has emerged as a promisi...