A Dual-Crosslinked Collagen/Oxidized Cellulose Composite Sponge Synergistically Constructed via Polyelectrolyte Complexation for Efficient Emergency Hemostasis [0.03%]
一种通过聚电解质复合作用协同构建的双交联胶原/氧化纤维素复合海绵，用于高效应急止血
Yeqing He,Zhaohui Sun,Ruixin Guo et al.
Yeqing He et al.
The development of effective hemostatic materials for acute hemorrhage control remains a significant clinical challenge. This study presents a dual-crosslinked hemostatic sponge fabricated by modifying collagen (COL) with dialdehyde oxidize...
A Bioelectric Therapy for Glioblastoma: Stimulating Purinergic Signaling via Pulsed Electric Fields [0.03%]
一种针对胶质母细胞瘤的生物电疗法：通过脉冲电场刺激嘌呤能信号转导
Marie Celine Lefevre,Nathan Dumas,Romanos Poulkouras et al.
Marie Celine Lefevre et al.
Glioblastoma is a highly aggressive brain cancer with limited treatment options due to the blood-brain barrier and the development of acquired chemoresistance. Bioelectric therapies, including pulsed electric field (PEF) treatment, have sho...
Single-Doped W18O49-x@Au-Embedded Dual-Network Silk Fibroin Hydrogel for NIR-Responsive Phototherapeutic Wound Healing [0.03%]
单掺杂W18O49-x@Au-嵌入双网络丝素蛋白水凝胶用于近红外响应性光疗伤口愈合
Chaofan Yao,Yu Zhao,You Wu et al.
Chaofan Yao et al.
Bacterial infections remain a critical challenge in wound care, demanding advanced multifunctional materials for effective treatment. Here, this work presents a 3D-printable hydrogel (STFWA) integrating a Schottky heterojunction and dual-ne...
Sustained Activation of Nrf2 Antioxidant Pathway by Flexible Liposome Based on Low Phase Transition Temperature to Delay Skin Aging [0.03%]
基于低相变温度的柔性脂质体激活Nrf2抗氧化途径延缓皮肤衰老
Huihui Liu,Yilong Hu,Wanting Ji et al.
Huihui Liu et al.
Intrinsic skin aging and photoaging induce alterations in skin morphology and increase the risk of skin diseases. Reactive oxygen species (ROS) are key contributors to these processes, and nuclear factor erythroid 2-related factor 2 (Nrf2),...
Integrating Disease Mechanisms and Design Strategies in Gradient Biomaterials for Soft-Hard Tissue Interfaces [0.03%]
用于软硬组织界面的梯度生物材料的疾病机制和设计策略整合
Tan Chen,Yao Jiang,Jiaping Huang et al.
Tan Chen et al.
Engineered soft-hard tissue interfaces such as the tendon-bone, cartilage-bone, bone-ligament, and periodontal complexes are essential for load transfer and functional integration. However, injuries or degeneration at these sites is highly ...
Hannah M Zlotnick,Declan N Goddard,Jason A Burdick
Hannah M Zlotnick
Orthopedic tissue-on-a-chip systems are rapidly emerging to model tissue homeostasis and disease, including to screen new therapeutics. These platforms range in complexity, related to the number of cells, materials, and other factors that a...
Phase Separation-Induced Surface Protuberances in Hydrogel Particles for Enhanced Intestinal Retention [0.03%]
相分离诱导的水凝胶颗粒表面突起用于增强肠道滞留效应
Bin Kong,Rui Liu,Yang Zhao et al.
Bin Kong et al.
The surface roughness of microparticles enhances their biological interactions; however, engineering such features in fully assembled polymeric membranes remains challenging. Inspired by natural budding phenomena, this study developed solve...
Advancing Cancer Diagnostics: Technologies for Quantifying the Particle Concentration of Extracellular Vesicles in Complex Biological Samples [0.03%]
癌症诊断的技术进步：定量复杂生物样本中细胞外囊泡颗粒浓度的技术
Gisela Ströhle,Manjusri Misra,Huiyan Li
Gisela Ströhle
Extracellular vesicles (EVs) have emerged as pivotal mediators in cancer biology, offering unprecedented opportunities for early detection and real-time disease monitoring. These nanoscale cargo carriers, which mirror the molecular signatur...
Harnessing Advances in Bone Tissue Engineering for Design of Bone-on-Chip Systems [0.03%]
利用骨组织工程学的进展设计芯片上的骨系统
Farhad Sanaei,Yannick Hajee,Gerry L Koons et al.
Farhad Sanaei et al.
Organ-on-Chip systems demonstrate significant potential as next-generation models to study human (patho)physiology and to assess new therapies. Whereas on-chip models of soft tissues and organs have progressed substantially over the past de...
Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review [0.03%]
肌腱再生中脱细胞基质材料的研究进展及临床应用前景综述
Kumaresan Sakthiabirami,Yeonwoo Park,Seong Kyeong Jo et al.
Kumaresan Sakthiabirami et al.
Tendon injuries pose significant clinical challenges due to complex structure and limited healing capacity. Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoti...