Spatial Transcriptomics-Inspired Targeted Hydrogel for Dental Pulp Therapy via Strengthen Macrophage Communication [0.03%]
灵感源自空间转录组学的牙髓治疗用凝胶及其强化巨噬细胞通信的方法研究
Mingmei Yang,Houwang Lai,Fan Wu et al.
Mingmei Yang et al.
Tissue repair depends on how inflammatory cues drive regenerative cell-state transitions; a process poorly understood in human tissues. Human dental pulp provides an accessible, structurally well-defined injury model with robust clinical re...
Engineered Exosome-Mediated FIH-1 Delivery for Targeted Therapy of Hyperuricemic Nephropathy by Inhibiting NF-κB/NLRP3 Inflammasome Signaling and Restoring Autophagic Homeostasis [0.03%]
工程化外泌体递送FIH-1治疗高尿酸血症肾病：通过抑制NF-κB/NLRP3炎性小体信号及恢复自噬稳态实现靶向治疗
Ting Xiao,Yu Liu,Zhe He et al.
Ting Xiao et al.
Renal tubular epithelial fibrosis is a key pathological process in the progression of hyperuricemia (HUA), and hyperuricemic nephropathy (HN). Targeted inhibition of renal tubular epithelial cell (RTEC) fibrosis represents a promising thera...
Targeted NIR-II Photothermal Therapy Enabled by Bioorthogonal Click Reaction With Olympicenyl Radical Nanoparticles [0.03%]
基于生物正交点击反应的奥运烯自由基纳米颗粒介导的近红外二区光热治疗
Mingzhe Wang,Xingchi Liu,Jinlian Hu et al.
Mingzhe Wang et al.
This study presents an application of delocalized hydrocarbon neutral monoradical, an olympicenyl radical (OR6), as a high-performance organic photothermal agent (PTA) for targeted photothermal therapy (PTT). By encapsulating OR6 into funct...
Cell-Cell Interaction of Chondrocytes in Porous Alginate Hydrogels With Different Spatial Cell Distributions and Its Influence on Cell Functions [0.03%]
具有不同空间细胞分布的多孔海藻酸盐水凝胶中软骨细胞的细胞相互作用及其对细胞功能的影响
Mingxin Zhang,Huajian Chen,Tianjiao Zeng et al.
Mingxin Zhang et al.
Cell-cell interactions play a critical role in regulating chondrocyte functions and cell fate. However, how the transition from single-cell dispersion to multicellular aggregation affects chondrocyte functions has not yet been systematicall...
Decoration of Porous TiO2 Implants With Metal-Organic Composites Enables Synergistic Therapy for Osteoporotic Fracture Healing [0.03%]
金属有机复合材料修饰多孔二氧化钛植入物可促进骨质疏松性骨折愈合的协同治疗
Xinyi Huang,Shaoyin Wei,Zhenqian Sun et al.
Xinyi Huang et al.
Osteoporotic fracture healing is trapped in a vicious cycle where multiple pathological factors, including persistent oxidative stress, inadequate vascular supply, and an imbalance bone remodeling process that favors resorption, combine to ...
Algae-Integrated Optoelectronic Nanoplatform for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy [0.03%]
用于肿瘤低氧缓解和增强光动力治疗的海藻结合型光电纳米平台
Gongcheng Ma,Nan Zhang,Hongrong Shi et al.
Gongcheng Ma et al.
The clinical efficacy of photodynamic therapy (PDT) is fundamentally limited by the scarcity of efficient photosensitizers (PSs) and the oxygen dependence of singlet-oxygen-mediated cytotoxicity. Here we report pentaperylene decaimide selen...
A Bioorthogonal Ratiometric Fluorescence Nanoprobe for Imaging the Regulation of O-GlcNAcylation in Atherosclerosis [0.03%]
一种用于成像动脉粥样硬化中O-GlcNAc酰化调控的生物正交比值型荧光纳米探针
Jiheng Xu,Wei Zhang,Ping Li et al.
Jiheng Xu et al.
Protein post-translational modification (PTM) plays a significant role in the progression of atherosclerosis (AS). However, the role of O-GlcNAcylation, as an important O-glycosylation modification, in the formation of foam cells remains un...
A Bioorthogonal Ratiometric Fluorescence Nanoprobe for Imaging the Regulation of O-GlcNAcylation in Atherosclerosis [0.03%]
一种用于成像动脉粥样硬化中O-GlcNAc酰化调控的生物正交比值型荧光纳米探针
Jiheng Xu,Wei Zhang,Ping Li et al.
Jiheng Xu et al.
Protein post-translational modification (PTM) plays a significant role in the progression of atherosclerosis (AS). However, the role of O-GlcNAcylation, as an important O-glycosylation modification, in the formation of foam cells remains un...
A Bioorthogonal Ratiometric Fluorescence Nanoprobe for Imaging the Regulation of O-GlcNAcylation in Atherosclerosis [0.03%]
一种用于成像动脉粥样硬化中O-连接的N-乙酰氨基葡萄糖(O-GlcNAc)调节情况的生物正交比率型荧光纳米探针
Jiheng Xu,Wei Zhang,Ping Li et al.
Jiheng Xu et al.
Protein post-translational modification (PTM) plays a significant role in the progression of atherosclerosis (AS). However, the role of O-GlcNAcylation, as an important O-glycosylation modification, in the formation of foam cells remains un...
Chuanxiong Extract-Decorated Mitochondria-Targeted Nanocarriers Attenuate Infarct Injury by Restoring Mitochondrial Homeostasis and Blocking Oxidative Cascade [0.03%]
红花提取物修饰的线粒体靶向纳米递药系统通过恢复线粒体稳态及阻断氧化级联反应抑制心肌梗死损伤
Qinran Chen,Yaxi He,Guangbing Luo et al.
Qinran Chen et al.
The complex phytochemical composition of Traditional Chinese Medicines (TCM) like Ligusticum chuanxiong offers multi-target therapeutic potential, yet their intracellular mechanisms remain largely undefined due to a lack of suitable investi...