Biomimetic Mineralization and Enzymatic Tailoring of Bacterial Cellulose Towards Degradable, Mechanically Adaptive Substitutes with Enhanced Bioactivity and Cerebrospinal Fluid Barrier Properties [0.03%]
Yang Zheng,Jia Li,Yi Liu et al.
Yang Zheng et al.
Artificially degradable dura mater substitutes are critical for protecting brain tissue and cerebrospinal fluid (CSF), yet current materials struggle with biomechanical mismatches, uncontrolled degradation, permeability, and limited bioacti...
Engineering Next-Generation Vascular Grafts with Improved Endothelialization and Long-Term Patency [0.03%]
Janeesh Das P,Krishnameera Sajayan,Sagar Devakate et al.
Janeesh Das P et al.
The rising global burden of cardiovascular diseases has intensified the demand for vascular grafts (VGs) that provide mechanical durability and hemocompatibility for replacing damaged or occluded vessels. While autologous conduits remain th...
Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti-Apoptotic, and Neurotrophic Treatments [0.03%]
Thelma Akanchise,Fucen Luo,Borislav Angelov et al.
Thelma Akanchise et al.
Neurodegenerative diseases present a significant challenge in modern medicine, largely due to the interplay of oxidative stress, apoptosis, and neuroinflammation. The development of advanced materials capable of simultaneously regulating mu...
Multimodal Imaging and Therapeutic Effects of Targeted Phase Change Nanoparticles in Venous Thromboembolism [0.03%]
Zi-Cheng Hu,Xun Yang,Yang Cao et al.
Zi-Cheng Hu et al.
Venous thromboembolism (VTE) remains a critical clinical challenge due to limitations in conventional therapies, including poor thrombus targeting, inadequate imaging, and bleeding risks. This study develops nanoparticles composed of polyla...
Hemostatic Sponge With Excellent Wet Tissue Adhesion Performance for Anticoagulant-Associated and Unsuturable Visceral Hemorrhage Management [0.03%]
Yuwei Li,Yu Gao,Nan Jiang et al.
Yuwei Li et al.
The management of uncontrolled hemorrhage in anticoagulant-associated patients and visceral trauma necessitates hemostatic agents that operate independently of classical coagulation pathways. Herein, we report a gelatin sponge patch by one-...
Beatriz Peñín,Raúl Losantos,Ignacio Funes-Ardoiz et al.
Beatriz Peñín et al.
High-energy visible radiation (HEVR) induces adverse effects on the skin, yet a limited number of commercial compounds have been approved for use in humans. As most conventional filters are ineffective in this region, there is an urgent nee...
Ruisi He,Xinyue Cao,Zhuhao Wu et al.
Ruisi He et al.
Tissue engineering technique exhibits considerable therapeutic potential in skin injuries treatment. Current efforts in this area mainly focus on improving the cells diversity, density and spatial distribution to enhance therapeutic effects...
Rethinking Neuroregenerative Microenvironments: Synergy Between Bioengineering and Organoids [0.03%]
He Zhu,Kai Guo,Juan Feng et al.
He Zhu et al.
Neurological injuries and neurodegenerative disorders, including spinal cord injury, traumatic brain injury, stroke, and Parkinson's disease remain largely incurable. In the central nervous system (CNS), a self-reinforcing cascade of neuroi...
Enhanced Endoscopic Internal Drainage of Gastric Abscess Through Additively Manufactured Stents [0.03%]
Parima Phowarasoontorn,Yongbin Ko,Juan S Barajas-Gamboa et al.
Parima Phowarasoontorn et al.
Postoperative gastric leaks (GL), a serious complication of bariatric surgery, are often managed by endoscopic internal drainage using biliary double-pigtail stents (DPS). However, conventional extruded thermoplastic (e.g., polyethylene, po...
Oxime Sulfonates-Based Photoinitiator Activates Pyroptosis and Ferroptosis for Hypoxia Tumor Therapy [0.03%]
Qiyu Zhan,Lidong Deng,Qiyan Li et al.
Qiyu Zhan et al.
The development of biocompatible and efficient photo-triggered hydrogen abstraction systems holds considerable promise for the oxidation of NADH, thereby disrupting the NADH/NAD+ balance, modulating redox homeostasis, and advancing therapeu...