Proton Sponge-Enabled Dual-Driven Nanomotors for MRI-Guided Tumor-Penetrating Synergistic Therapy of Pancreatic Cancer [0.03%]
用于胰腺癌MRI引导肿瘤渗透协同治疗的质子海绵驱动纳米电机
Shuai He,Fulin Li,Pan Yang et al.
Shuai He et al.
Dense stromal barriers and lysosomal sequestration severely restrict the extracellular transport and intracellular trafficking of nanomedicines in pancreatic cancer, while the robust glutathione (GSH)-dependent antioxidant defense further c...
Tumor-Targeted Hyaluronic Acid/Tannic Acid-Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual-Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment [0.03%]
负载IR780的肿瘤靶向透明质酸/单宁酸工程氧气纳米生成器用于黑色素瘤治疗中的双模式谷胱甘肽耗尽及有效单线态氧生成疗法
Chai-How Hsu,I-Ju Liu,Hsiang-Yun Chih et al.
Chai-How Hsu et al.
Despite advances in combined photothermal (PTT) and photodynamic (PDT) therapy for melanoma, therapeutic efficacy remains limited by tumor hypoxia, intracellular glutathione (GSH), insufficient tumor targeting, and photobleaching of photose...
Rare-Earth-Functionalized Carbon Dot Hydrogels as Mechanically Robust Antibacterial Wound Dressings [0.03%]
罕见地球元素功能化碳点水凝胶的抗菌伤口敷料
Shih-Han Tsai,Ramadhass Keerthika Devi,Muthusankar Ganesan et al.
Shih-Han Tsai et al.
Hydrogel-based wound dressings have attracted sustained interest due to their ability to support fibroblast proliferation and maintain a moist healing environment; however, achieving simultaneous antibacterial efficacy, mechanical robustnes...
Pyroptosis-Inducing Nanomedicine for Cancer Immunotherapy: Mechanisms and Emerging Strategies [0.03%]
癌症免疫治疗的诱导式纳米药物：机制与新兴策略
Pengfei Wang,Xinxin Sun,Yuning Yang et al.
Pengfei Wang et al.
Cancer immunotherapy has revolutionized oncologic treatment, yet its efficacy remains constrained by tumor immune evasion and the immunosuppressive tumor microenvironment. Addressing these multifaceted barriers calls for strategies that can...
A Non-Cryogenic Dugout-Structured Microneedle Patch for Co-Delivery of Irisin and Fibroblasts in Diabetic Wound Repair [0.03%]
一种非 cryo-genic dugout-结构的微针贴片，可协同递送 Irisin 和成纤维细胞以修复糖尿病伤口
Yu-Chi Pan,Hsi-Chen Tung,Ying-Tzu Chen et al.
Yu-Chi Pan et al.
Diabetic wounds remain difficult to treat due to persistent inflammation and impaired fibroblast function, which slow tissue repair. Microneedle systems provide a minimally invasive route for localized delivery, but live-cell applications h...
Ferritin-Inspired Mineralized Iron Phosphate Nanominerals for Precision Ferroptosis-Immunotherapy via Controlled Iron Storage and Release [0.03%]
受铁蛋白启发的铁磷酸化纳米矿物，通过控制储铁和释铁用于精确铁死亡-免疫治疗
Hanyu Zhang,Yongsheng Li,Qiang Wu et al.
Hanyu Zhang et al.
Ferroptosis provides promising method for tumor therapy but is limited by the low efficiency and safety concerns of conventional iron delivery systems. Herein, we report efficient ferritin-mimetic nanominerals engineered via a small molecul...
Stem Cell-Derived Mitochondria-Enriched Preservation Solutions as Organelle-Based Therapeutic Strategy for Cold Storage of Liver and Kidney [0.03%]
基于干细胞的线粒体富集保存液作为器官冷保存的 organoid 疗法在肝肾保存中的应用
Fang Lin,Jianxin Jiang,Jing Liu et al.
Fang Lin et al.
Organ preservation remains a critical challenge in transplantation, primarily due to hypothermia-induced oxidative stress and metabolic dysfunction. Here, we report a mitochondria-enriched, cell-free preservation strategy by supplementing s...
A Novel Drug-Loaded Porous Parylene Electrode for Targeted Anti-Inflammatory Therapy and Hearing Preservation in Cochlear Implantation [0.03%]
一种新型载药多孔聚对二甲苯电极用于人工耳蜗植入时的 targeted 抗炎治疗和听力保护
Chi-Chieh Chang,Ying-Chang Lu,Yu-Ming Chang et al.
Chi-Chieh Chang et al.
This study investigates the feasibility and therapeutic effectiveness of a novel drug‑loaded parylene electrode prototype (PEP) designed to reduce inflammation and hearing loss associated with cochlear implantation (CI). The porous PEP was...
A Unifying Dental Gel for Enamel-Remineralization, and Whitening Effects [0.03%]
一种统一的牙科凝胶，用于牙釉质再矿化和美白效果
Hong Yue,Xinxue Tang,Jie Zhou et al.
Hong Yue et al.
This study reports a multifunctional dental gel of calcium peroxide-amorphous calcium carbonate phosphate (CaO2-ACCP), capable of synergistically repairing damaged dentin, tooth-whitening, and exerting antibacterial activity. The CaO2 nanop...
Multifunctional Janus Membrane Promotes Neurovascular Network Regeneration for Diabetic Wound Healing [0.03%]
用于糖尿病伤口愈合的促进神经血管网络再生的Janus膜
Zouwei Li,Renxin Chen,Yezheng Wang et al.
Zouwei Li et al.
The complex microenvironment of diabetic wounds poses a formidable challenge to tissue repair, particularly due to the absence of a functional neurovascular network. In this study, we developed a multifunctional Janus-structured scaffold (P...