Phase-Separated Nanoarchitecture of Adhesion-Cytoskeleton Force Coupling Reforms Nuclear Spatiotemporal Posture Conformation and Mechanotransduction of Osteosarcoma on Biofunctional Microarrays [0.03%]
生物功能微阵列上成骨肉瘤的细胞外基质相互作用力耦联相分离纳米结构重塑其时空核力学构象和机械转导机制
Huayu Fan,Xinxin Cui,Yan Hou et al.
Huayu Fan et al.
Osteosarcoma is widely concerned because it is a malignant tumor with a high incidence rate among teenagers. Although some chemical, physical, and synergetic technologies have been developed to treat malignant osteosarcoma, molecular mechan...
A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses [0.03%]
一种监测神经损伤反应的三维人类神经芯片平台
Ruiping Tang,Charles-Francois Latchoumane,Avi Chopra et al.
Ruiping Tang et al.
Traumatic brain injury (TBI) is a major cause of neurological dysfunction and long-term neurodegeneration, yet the intrinsic neuronal contributions to TBI pathophysiology remain incompletely defined. Here, we present a novel Neuron-on-Chip ...
Injectable Thermoresponsive Hybrid Hydrogel for Localized Chemo-Immunotherapy via Co-Delivery of Doxorubicin-Loaded Tumor-Derived Exosomes and Immunoadjuvants [0.03%]
负载多西他赛的肿瘤来源型外泌体与免疫佐剂共递送的温敏型杂化水凝胶的局部综合治疗注射液
Yunan Yuan,Yijun Wu,Jiaxuan Yang et al.
Yunan Yuan et al.
The therapeutic efficacy of melanoma immunochemotherapy is severely limited by insufficient intratumoral drug retention, systemic toxicity, and immunosuppressive tumor microenvironment (TME). Thus, we developed a single-dose injectable loca...
Hyaluronic Acid-Based Injectable Dual-Network Hydrogel for 6'-Sialyllactose Mimetic Peptide Delivery and Microenvironment Reconstruction in Brachial Plexus Root Avulsion [0.03%]
一种透明质酸基双网络水凝胶，用于递送类六磷酸神经节糖苷肽并重构臂丛神经根撕脱的微环境
Fubing Xiao,Ying Ding,Cong Ning et al.
Fubing Xiao et al.
Brachial plexus root avulsion (BPRA) results in extensive motor neurons (MNs) loss, muscle atrophy, and irreversible motor dysfunction. Current surgical strategies with reimplantation fail to promote the motor recovery often leading to poor...
Advanced Nanomaterials for Chronic Wounds: M.O.I.S.T. Concept-Driven Design Strategy [0.03%]
用于慢性伤口的高级纳米材料：由M.O.I.S.T.概念驱动的设计策略
Yingying Li,Chen Hu,Keyi Fang et al.
Yingying Li et al.
Clinical management of chronic wounds remains a major challenge, stemming from their complex etiology, high infection risk, and pronounced inter-patient variability. While nanomaterials offer innovative solutions to overcome the limitations...
Dual-Locked Glutathione-Activatable Nanoassemblies With Cascade Energy Transfer for Amplified Photodynamic Immunotherapy [0.03%]
双锁定谷胱甘肽激活的纳米组装体通过级联能量转移用于增强光动力免疫治疗
Xuan Zhang,Bin Dong,Shan Su et al.
Xuan Zhang et al.
Photodynamic immunotherapy is constrained by the immunosuppressive tumor microenvironment (TME) that scavenges reactive oxygen species (ROS) and limits immunogenic cell death. Lanthanide-doped upconversion nanoparticles enable near-infrared...
A Naphthalimide-Based NIR-Emissive AIE Photosensitizer for Synergistic Apoptosis/Ferroptosis-Mediated Antitumor Therapy and Broad-Spectrum Bacterial Inactivation With Rapid Wound Healing [0.03%]
一种萘酰亚胺基近红外发光AIE型光敏剂协同介导抗肿瘤治疗和广谱快速细菌消杀促伤口愈合的化学小分子疗法研究
Sayed Mir Sayed,Zeeshan Tahir,Fahri Alkan et al.
Sayed Mir Sayed et al.
Fluorescence-guided photodynamic therapy (PDT) that targets both malignant cells and pathogenic bacteria is attractive yet challenging, because a single photosensitizer (PS) must combine near-infrared (NIR) emission, efficient reactive oxyg...
Correction to "Coacervates Made of Elastin-Like Polypeptides Fused with Melanocyte-Stimulating Hormone and Monocyte Chemoattractant Protein Enhance Skin Wound Healing in Spinal Cord-Injured Mice" [0.03%]
弹性蛋白多肽与黑素细胞刺激激素和单核细胞趋化蛋白融合的缔合滴聚体可增强脊髓损伤小鼠皮肤伤口愈合的研究订正通知
Published Erratum
Advanced healthcare materials. 2026 Jul 29:e71518. DOI:10.1002/adhm.71518 2026
A Cathepsin-Triggered Size-Shrinkable Nanoparticle Enhances Fibrous Cap Penetration to Relieve Atherosclerosis [0.03%]
一种 cathepsin 诱导的尺寸缩小型纳米粒子增强纤维帽渗透以缓解动脉粥样硬化
Xiaoya Liang,Maochang Xu,Daobin Wu et al.
Xiaoya Liang et al.
In the microenvironment of atherosclerosis (AS), excessive migration of vascular smooth muscle cells led to the formation of a thick fibrous cap. This structure acted as a physical barrier and hindered efficient drug delivery to lesional ma...
Blood-Coagulation-Inspired Dual-Network Hydrogel with Delayed In Situ Gelation for Enhancing Intradiscal Diffusion and Promoting Intervertebral Disc Degeneration Repair [0.03%]
一种模仿血液凝固机理的具有延迟原位交联特性的双网络水凝胶及其在椎间盘退变修复中的应用研究
Minglang Zou,Yifan Wang,Junyao Cheng et al.
Minglang Zou et al.
Injectable hydrogels offer a promising strategy for treating intervertebral disc degeneration (IVDD), a leading cause of chronic low back pain. However, effective intradiscal diffusion and timely in situ gelation remain challenging within t...