Phellodendron amurense Rupr. Polysaccharides protects against diabetic nephropathy via alteration of PI3K/GSK-3β/Nrf2/TGF-β/Smad signaling pathway and gut microbiota [0.03%]
黄檗多糖通过改变PI3K/GSK-3β/Nrf2/TGF-β/Smads信号通路和肠道微生物群来预防糖尿病肾病
Mei Mei,Huawei Sun,Kai Zhang et al.
Mei Mei et al.
In this study, a diabetic nephropathy (DN) rat model was established using 2% Streptozocin (STZ) solution, and an in vitro DN model was constructed by stimulating HK-2 cells with 30 mM glucose to investigate the mechanism of Phellodendron a...
The role of bacteriophages and CRISPR-Cas in combating multidrug-resistant bacteria [0.03%]
细菌噬菌体和CRISPR-Cas在对抗多重耐药细菌中的作用
Ciamak Ghazaei
Ciamak Ghazaei
The alarming increase of multidrug-resistant (MDR) bacteria presents a serious global health crisis, reducing the effectivenessof traditional antibiotics and requiring alternative therapeutic strategies. Among the most promising innovations...
Mevalonic acid exerts procoagulant effect by potentiating factor Xa [0.03%]
异戊酸通过增强凝血酶原激酶FXa的作用促进血液凝固反应
Liyuan Niu,Chuanfeng Liu,Shaoying Wang et al.
Liyuan Niu et al.
Thrombosis pathogenesis is closely linked to dysregulated lipid metabolism and inflammatory processes. However, the direct regulatory role of mevalonate pathway within the coagulation cascade is still not well understood. This study aimed t...
Panunoids A - D, four new prenylhydroquinone derivatives isolated from the fungus Panus rudis [0.03%]
源自齿瑚菌的新倍半奎宁环衍生物帕努诺因A-D
Yun Liu,Jian-Qiang Zhao,Yan-Long Yang et al.
Yun Liu et al.
A chemical constituent study on the fermented rice substrate of basidiomycetous fungus Panus rudis led to the isolation of four previously undescribed prenylhydroquinone derivatives compounds (1-4) and eight known compounds (5-12). Among th...
Metabolomics reveal how strong water binding naturally enhances wheat seed longevity and Fusarium resistance [0.03%]
代谢组学揭示了强结合水如何自然增强小麦种子的寿命和抗 Fusarium 病害能力
Lorenzo Goglia,Vito Campanella,Agata Rascio
Lorenzo Goglia
Seed water content affects wheat quality, storage, and food safety, influencing viability and fungal contamination risks. Grain moisture is influenced by both genetic and environmental factors, with agronomic practices aiming to optimize it...
Unraveling the metabolic potential and roles of reductases in the omicsynin biosynthetic gene cluster [0.03%]
解开Omicsynin生物合成基因簇中还原酶的代谢潜能及作用机制
Yihong Li,Jie Fu,Hongmin Sun et al.
Yihong Li et al.
Omicsynins are a group of pseudo-tetrapeptides produced by Streptomyces sp. 1647, which exhibited potent anti-influenza A virus and anti-coronavirus activities. However, its biosynthesis mechanism of C-terminus reduction remains unknown. In...
Novel triterpenoids from Ganoderma resinaceum attenuate UV-induced photoaging via modulating Nrf2 and MAPK signaling pathways [0.03%]
Ganoderma resinaceum 灵芝的新三萜类化合物通过调节Nrf2和MAPK信号通路缓解紫外线引起的皮肤光老化效应
Yi Luo,Xiao-Cui Liu,Yu-Jie Li et al.
Yi Luo et al.
As a dual-purpose medicinal and edible mushroom, Ganoderma species have garnered significant interest in both the food, cosmetics and pharmaceutical industries. To further substantiate its traditional and functional uses, we conducted a sys...
Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour [0.03%]
Aglaia odorata Lour中具有多维度神经保护活性的10个未报道倍半萜类化合物研究
Meng Ding,Yue-Han Wang,Chen-Hao Liu et al.
Meng Ding et al.
Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved...
Anti-obesity Effects of Panax ginseng-derived exosomes via AMPK-mediated inhibition of adipocyte differentiation and lipogenesis [0.03%]
通过AMPK介导的抑制脂肪细胞分化和脂质生成诱导的潘克斯人参源外泌体抗肥胖效应
Min Ho Han,Sun Hye Lee,Youn Seon Hwang et al.
Min Ho Han et al.
This study investigated the anti-obesity potential of Panax ginseng-derived exosomes (PGE) by evaluating their influence on energy metabolism, adipogenesis, and lipid accumulation. PGEs were isolated using a tangential flow filtration syste...
Diverse phloroglucinols with hAChE inhibitory and anti-VRE effects from Rhodomyrtus tomentosa fruits [0.03%]
Rhodomyrtus托木草果中具有抗VRE和hAChE抑制作用的多元菲咯啉醇类化合物
Ling-Yun Chen,Mu-Yuan Yu,E-E Luo et al.
Ling-Yun Chen et al.
Rhodomyrtus tomentosa fruits serve as both functional food and medicinal resources due to their rich bioactive constituents and manifold pharmacological effects. Phytochemical exploration of the R. tomentosa fruits led to the identification...