New patchoulol- and guaiane-type sesquiterpenoids from Sanguisorba officinalis with anti-melanogenic activity [0.03%]
具抗黑化活性的蛇床子素化合物新.patchoulenol和guaiane型茋倍半萜类成分
Long-Long Wu,Jia-Rui Wu,Kai-Xian Chen et al.
Long-Long Wu et al.
Twelve new sesquiterpenoids, sanguisorbaols A-L (1-12), along with twenty-five known compounds (13-37), were isolated from the roots of Sanguisorba officinalis. Structures were determined through comprehensive analysis of HRESIMS, 1D and 2D...
Four new Cyclohexenone with antibacterial activity from the coral-derived fungus Aspergillus flavus [0.03%]
来源于棘球孢子菌的4种具有抗菌活性的环己内酯类化合物
Cili Wang,Jiarui Zhang,Lei Li et al.
Cili Wang et al.
Marine fungus-derived natural products are an important source of new drugs and lead compounds. In this study, guided by the Global Natural Products Social (GNPS) molecular networking strategy, four new cyclohexenone derivatives, aspergiflo...
Mechanistic insights into polyphenolic constituents from traditional Chinese medicines in inhibiting colorectal cancer metastasis [0.03%]
基于传统中药的多酚类成分抑制结直肠癌转移的作用机制研究
Ming-Hong Li,Lu Liu
Ming-Hong Li
Colorectal cancer (CRC) is the third most predominant cancer caused by genetic, environmental and nutritional factors and is the world's second most significant cause of cancer-related mortality. During the process of tumor metastasis, firs...
First total synthesis of (±)-spirobroussonin B via electromediated oxidative coupling for constructing spirodienone ring [0.03%]
介电氧化偶联构建螺环二酮环的手段并完成(±)-Spirobroquinoline B首次全合成
Hong-Ji Shi,Xing-Ping Zhang,Cong-Xi Gao et al.
Hong-Ji Shi et al.
An electromediated oxidative coupling strategy for constructing spirodienone fragment has been developed and applied as the key step for the total synthesis of (±)-spirobroussonin B. This concise route was accomplished in only four steps, ...
Facile synthesis and biological evaluation of glomuferrin and rhizoferrin as ferroptosis inhibitors in rice blast disease [0.03%]
一种简单的合成和生物评价方法：可用于防治水稻稻瘟病的胶束铁和丛生铁合成及生物评价
Anna Fusetti,Francesca Annunziata,Michael S Christodoulou et al.
Anna Fusetti et al.
Iron homeostasis has recently emerged as a key determinant in the early stages of plant-pathogen interactions, particularly in phytopathogens that exploit iron-dependent cell death (known as ferroptosis) to initiate host invasion. In Pyricu...
Peng-Ju Xu,Ai-Lin Liang,Wen-Yu Lu et al.
Peng-Ju Xu et al.
Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (3), and seven new trichothecene sesquiterpenoids, trichot...
Diversity of oligosaccharides in lipooligosaccharides of Akkermansia muciniphila and its anti-atherosclerotic activity [0.03%]
Akkermansia黏蛋白聚糖脂寡糖结构多样性及其抗动脉粥样硬化活性
Yuting Zhang,Wang Dong,Jinghan Lin et al.
Yuting Zhang et al.
As an important and beneficial gut commensal, Akkermansia muciniphila plays a crucial role in regulating host metabolism and immunity. Lipooligosaccharides from A. muciniphila (ALOS) show anti-obesity effects in high-fat diet-fed mice. Here...
Prenylated acylphloroglucinols from the fruits of Hypericum patulum [0.03%]
膜荚 hypericum果实中的牻牛儿基代酰基 phloroglucinol类化合物
Yu-Feng Qiu,Yi Zhou,Cheng Chen et al.
Yu-Feng Qiu et al.
Twenty-eight prenylated acylphloroglucinols, including the new hypulatones C-F (1-4), have been isolated from the fruits of Hypericum patulum and structurally characterized. Compound 1 represents a rare meroterpenoid formed through the addi...
Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans [0.03%]
牻牛儿醇通过激活秀丽隐杆线虫的SKN-1/Nrf2活性来促进抗氧化防御和抗逆性
Stéfano Romussi,Ailin Lacour,Diego Rayes et al.
Stéfano Romussi et al.
Oxidative stress (OS) is a major contributor to aging and the pathogenesis of numerous conditions, including diabetes, neurodegenerative, cardiovascular, and autoimmune disorders. Consequently, therapeutic strategies aimed at enhancing endo...
Artificial intelligence-based screening of phytochemicals for targeted cancer therapy [0.03%]
基于人工智能的植物化学成分靶向癌症治疗筛选研究
Livia Ramos Santiago,Estéfani Alves Asevedo,Maria Eduarda Jeunon de Oliveira et al.
Livia Ramos Santiago et al.
Cancer remains one of the leading causes of death worldwide and continues to pose a serious public health challenge. The limited success of many current treatments-often due to toxicity, poor selectivity, and the development of drug resista...