Discovery of pyridomycin derivatives as InhA inhibitors from actinomycetes through molecular networking and an In-House tandem mass library [0.03%]
基于分子网络和实验室内的串联质谱库从放线菌中发现抑制结核分枝杆菌InhA的批大霉素衍生物
Byeongsan Lee,Gwi Ja Hwang,Jun-Pil Jang et al.
Byeongsan Lee et al.
A screen of ~ 4000 actinomycetes strains identified Streptomyces sp. W3009 as a producer of the antituberculosis agent pyridomycin. Using a mass spectrometry-based metabolomics approach coupled with molecular networking, we identified seven...
Cortinarius mapuveronicae from South America, a chemical and morphological link between European and Australian dermocyboid Cortinarii [0.03%]
南美红球菌属地图 Veronica 药用变种：欧洲和澳大利亚红球菌属色素种类的化学和形态学联系
Josefine Lange,Lesley Huymann,Sophie Schwarzkopf et al.
Josefine Lange et al.
The new species Cortinarius mapuveronicae from Andean-Patagonian Nothofagus-forests is described in a polythetic approach combining chemical analysis of the anthraquinonoid secondary metabolites, microscopical and morphological characterist...
Mining anticoagulant peptides from Poecilobdella manillensis by peptidomics analysis [0.03%]
基于肽组学分析从曼氏血吸虫中挖掘抗凝活性多肽
Han-Xue Zheng,Xiao-Li Deng,Teng-Teng Li et al.
Han-Xue Zheng et al.
Thrombosis triggers various severe diseases, while antithrombotic drugs carry bleeding risks, making the development of novel natural anticoagulants a subject of widespread attention. Poecilobdella manillensis, a prevalent medicinal leech, ...
Dietary ellagic acid inhibiting gastrointestinal pathogens by modulation of microbiome-metabolite-immune axis [0.03%]
膳食Ellagic酸通过调节微生物组-代谢物-免疫轴抑制肠道病原菌
Li-Na Mei,Jia-Shan Shen,Yu Duan et al.
Li-Na Mei et al.
Antibiotic-induced depletion of the gut microbiota facilitated the colonization of vancomycin-resistant Enterococci (VRE) in the gastrointestinal tract, and then increased patients' susceptibility to secondary infections. Ellagic acid, a ma...
Genome mining reveals the unique function of UbiA-type prenyltransferase in Laetiporus sulphureus [0.03%]
基因组挖掘揭示了Laetiporus sulphureus中UbiA型焦磷酸二酯酶的特有功能
Yue Wang,Qian Wang,Chunlei Wang et al.
Yue Wang et al.
Eight UbiA-type prenyltransferases were mined in Laetiporus sulphureus by bioinformatic analysis, and phylogenetic analysis showed that they have unique functions. Through heterologous expression in Aspergillus oryzae and addition of exogen...
Xylanins A-P, sixteen new guaiane-type dimers from the branches and leaves of Xylopia vielana with anti-proliferative activity against PANC-1 cell line [0.03%]
来自XYLOPIA VIELANA枝和叶的十六种新的香树烷型二聚体木聚糖素A-P及其对PANC-1细胞系增殖的抑制作用
Xianglian Jiang,Ting Zhang,Fancheng Meng et al.
Xianglian Jiang et al.
Sixteen previously undiscovered guaiane-type sesquiterpene dimers, xylanins A-P (1-16), along with six known analogues (17-22), were isolated from the branches and leaves of Xylopia vielana with chromatographic techniques. Their structures ...
Monoterpene indole alkaloids from the aerial parts of Ophiorrhiza brevidentata and their immunological activities [0.03%]
Ophiorrhiza brevidentata地上部分来源的单萜吲哚生物碱及其免疫活性研究
Fan Xu,Zheng-Hui Li,Meng-Lin Feng et al.
Fan Xu et al.
Phytochemical study of the EtOAc extract of Ophiorrhiza brevidentata resulted in the discovery of 10 new monoterpene indole alkaloids (1-10), along with 13 known compounds (11 - 23). Compound 1 possess an unprecedented skeleton consisting o...
Enhancing detection of low‑abundance metabolites in proton NMR through band‑selective suppression and presaturation [0.03%]
利用带选择压制和预饱和提高氢核磁共振中低丰度代谢物的检测能力
Upendra Singh,Renad Z Al Ahmadi,Ruba Al-Nemi et al.
Upendra Singh et al.
Metabolomics provides powerful means to analyze metabolite profiles in biological samples, enabling insights into biochemical changes under genetic, environmental, or pathological conditions. Nuclear Magnetic Resonance (NMR) spectroscopy is...
Harziachalasins A-G, polycyclic-fused cytochalasins from the endophytic fungus Trichoderma harzianum MLJ-4 with HIV latency reversal activity [0.03%]
从内生真菌Trichoderma harzianum MLJ-4中分离得到的多环并合细胞松素Harziachalasins A-G及其抗HIV潜伏库活性研究
Yan-Jiang Zhang,Xian-Yuan Yang,Yi-Fan Fu et al.
Yan-Jiang Zhang et al.
Seven new polycyclic-fused cytochalasins (CYTs), harziachalasins A-G (1-7), together with three known analogues (8-10) were isolated from the solid culture of the endophytic fungus Trichoderma harzianum MLJ-4, which was originally isolated ...
Revolutionizing microbial treasure troves: innovative strategies for natural products discovery [0.03%]
革新三域生物宝库：天然产物发现的创新策略
Yu-Jie Li,Ming-Hua Qiu,Xing-Rong Peng
Yu-Jie Li
Microorganisms represent Earth's most abundant biological resource, producing metabolites of immense value across medicine, agriculture, and industry. Conventional cultivation and screening techniques, however, suffer from inefficiency and ...