Targeting Hsp70 triggers ferroptosis: a novel anti-cancer mechanism of a marine natural product in prostate cancer [0.03%]
靶向Hsp70引发铁死亡：海洋天然产物在前列腺癌中的新型抗肿瘤机制
Qiuyu Liu,Mengjing Cong,Chenghai Gao et al.
Qiuyu Liu et al.
Prostate cancer (PCa) remains one of the most common malignant tumors among men worldwide, typically relying on the androgen receptor (AR) signaling pathway. Inducing ferroptosis, a novel form of iron-dependent cell death, represents a prom...
Revitalizing actinobacteria research: an urgent response to the antimicrobial resistance crisis [0.03%]
应对微生物抗药性危机：复苏放线菌研究刻不容缓
Samuel Paulo Cibulski,Valnês da Silva Rodrigues-Junior
Samuel Paulo Cibulski
The crisis of antimicrobial resistance (AMR) is escalating while the antibiotic pipeline remains stagnant. Our bibliometric analysis of eight decades of literature reveals a critical imbalance: research on AMR has grown, yet fundamental res...
Combined treatment with naringin and osthole ameliorates colitis through microbiota-amino acid metabolism and the JNK pathway [0.03%]
柚皮素和欧洛林联合治疗通过微生物群-氨基酸代谢和JNK途径改善结肠炎
Mengqin Chen,Zihao Lu,Tong Zhang et al.
Mengqin Chen et al.
Inflammatory bowel disease (IBD), particularly ulcerative colitis, involves disruption of the intestinal mucosal barrier due to ecological and metabolic imbalances in the gut as its underlying pathology. Current therapies for Ulcerative col...
Three new 14-noreudesmane-type sesquiterpenoids from the roots of Hippophae rhamnoides [0.03%]
来自沙棘根的新三类14-脱氢马兜铃烷型倍半萜内酯类化合物
Fatima Abdurrahman Galadanchi,Polina Lopukhina,Sisi Bai et al.
Fatima Abdurrahman Galadanchi et al.
Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of th...
Pyrimidine-containing natural products: occurrences and biological activities [0.03%]
含嘧啶天然产物的研究及其生物活性
Jian-Neng Yao,Yongjie Zhu,He-Ping Chen et al.
Jian-Neng Yao et al.
Nitrogen-containing core structure pyrimidine has long been regarded as one of the privileged scaffolds for novel drug development. Natural products embedded with pyrimidine motifs are distinguished by their exceptional scaffold diversity a...
Polydosetins & pullularins-bioactive tetramic acids & cyclodepsipeptides from the endophytic and nematophagous fungus Polydomus karssenii [0.03%]
来自内生和线虫食菌真菌Polydomus karssenii的多多塞汀和泡斑素-四甲酸及环肽类生物活性化合物
Natalia A Llanos-López,Jan-Peer Wennrich,Janette Miled et al.
Natalia A Llanos-López et al.
In course of investigating the endophytic and nematode-associated fungus Polydomus karssenii for the production of secondary metabolites, seven previously undescribed natural products were isolated from liquid and solid-state fermentations....
Targeting Integrin β3: novel antiplatelet lignans 6'-Hydroxyjusticidin B and Neojusticin A from Justicia procumbens unveiled via multi-omics and biophysical validation [0.03%]
靶向整合素β3：新的抗血小板木脂体6'-羟基justicidin B和Neojusticin A从Justicia procumbens通过多组学和生物物理验证揭露出来
Meixian Xiang,Songtao Wu,Hanxiang Mei et al.
Meixian Xiang et al.
Thrombotic disorders remain a global health burden, necessitating novel antiplatelet agents with improved safety and efficacy. This study investigates the molecular mechanisms of two lignans, 6'-Hydroxyjusticidin B (6'-HJB) and Neojusticin ...
Genome mining and functional characterization of four type I sesquiterpene synthases from the Tiger Milk Mushroom Lignosus rhinocerus [0.03%]
基因组挖掘及虎奶菇四种I型倍半萜合成酶的功能表征
Ming-Xuan Gao,Li-Li Guo,Meng-Ting Wang et al.
Ming-Xuan Gao et al.
The Tiger Milk mushrooms (Lignosus spp.) have long been used as traditional folk medicines throughout Southeast Asia. However, the chemical constituents of these species remain largely unexplored. In this study, four type I sesquiterpene sy...
Eight new α-pyrone and γ-butenolide derivatives from the plant endophytic fungus Diaporthe sp. CCY4 [0.03%]
来自植物内生菌Diaporthe sp. CCY4的新α-吡喃酮和γ-丁内酯类化合物
Jie-Chun Zeng,Xu-Ping Zhang,Lu Gao et al.
Jie-Chun Zeng et al.
Five new α-pyrones, diaporpyrones G-K (1-5) and three new γ-butenolide derivatives, porbutenolides A-C (6-8), along with seven known compounds (9-15), were isolated from the culture extract of the endophytic fungus Diaporthe sp. CCY4. The...
Clerodane diterpenoid glycosides from the tuberous roots of Paratinospora sagittata: targeted isolation, structure characterization and immunomodulatory properties [0.03%]
具免疫调节活性的钩序黄连属中 clerodane 二萜苷类化合物的研究
Jun-Sheng Zhang,Rui Ao,Yin-Bo Pan et al.
Jun-Sheng Zhang et al.
Guided by the MS/MS-based molecular networking, eight previously undescribed clerodane diterpenoid glycosides, designated tinospinosides F-M (1-8), along with 12 known analogues (9-20), were isolated from the tuberous roots of Paratinospora...