A critical review on the roles of natural products in shaping oral microbiota and preventing chronic diseases [0.03%]
天然产物在塑造口腔微生物群和预防慢性疾病方面的作用的批判性评论
Yogesh Kumar,Baojun Xu
Yogesh Kumar
The oral microbiome plays a central role in maintaining both oral and systemic health, and disruptions in its balance can contribute to a wide range of diseases. This review brings together current evidence on how natural products modulate ...
Phenazinoates A‒E, five pairs of phenazine conjugates from a mangrove soil-derived Streptomyces strain OUCMDZ-4923 [0.03%]
来源于互花米草根际放线菌OUCMDZ-4923的菲尼嗪酸类化合物A-E
Dongyang Wang,Peipei Liu,Yukang Gao et al.
Dongyang Wang et al.
Phenazinoates A-E (1-5), comprising five pairs of methyl saphenate conjugates with genistein, o-aminophenol, p-acetaminophenol and glycerol, were isolated from the fermentation broth of mangrove soil-derived Streptomyces sp. OUCMDZ-4923. Th...
Calabanones A‒H, chromanone derivatives from the stem bark of Calophyllum calaba and their cytotoxic activities against cancer cells [0.03%]
来源于Calophyllum calaba树皮的Calabanones A-H及其抗肿瘤活性研究
Sutin Kaennakam,Fadjar Mulya,Manussada Ratanasak et al.
Sutin Kaennakam et al.
The genus Calophyllum (Calophyllaceae), distributed mainly in tropical regions, is rich in chromanone derivatives with diverse molecular structures that exhibit potential antimicrobial and anticancer effects. Phytochemical investigation of ...
Peniexpansones A-F: polyketides from Penicillium expansum DWS880 capable of enhancing the activity of fluconazole against Candida albicans [0.03%]
Peniexpansones A-F：产黄青霉DWS880的聚酮类化合物可增强氟康唑对白色念珠菌的作用
Wen-Yu Lu,Qing-Hui Xiao,Ai-Lin Liang et al.
Wen-Yu Lu et al.
Six new polyketides, peniexpansones A-F (1-4, 6, 7), along with an additional novel compound, (2E,4E,6E)-8-methyldeca-2,4,6-trienoic acid (5), and a known naphthopyrone, were isolated from the ethyl acetate extract of rice fermented with th...
Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008 [0.03%]
来源于链霉菌HKIB0008的3种萘诺霉素型聚酮类化合物
Yuan Chen,Fei Zhang,Zi-Kang Zhao et al.
Yuan Chen et al.
Three new naphthomycin derivatives were isolated and identified from Streptomyces sp. HKIB0008, and were designated as naphthomycin R (1), naphthomycin S (2), and naphthomycin T (3). Their structures were elucidated using a combination of s...
Colloidal lignin particles for Pickering emulsion stabilization: multifunctional properties and prospects for cosmetic applications [0.03%]
莱纳胶粒的Pickard乳液稳定作用：多功能性质及化妆品应用前景
Giovana Colucci,Alírio Egídio Rodrigues,Maria Filomena Barreiro
Giovana Colucci
Lignin, the most abundant aromatic biopolymer on Earth, is abundantly found as a by-product of biomass processing industries. Lignin presents remarkable properties, including antioxidant, UV-blocking, thermal stability, and antimicrobial; t...
De novo synthesis of plant polyketide plumbagin in yeast: a platform for sustainable production of naphthoquinones [0.03%]
从酵母中从头合成植物聚酮类棕榈碱：生产萘醌的可持续生产平台
Arati P Vasav,Vitthal T Barvkar
Arati P Vasav
Plumbagin is a natural naphthoquinone with different pharmacological properties and abundantly present in the roots of Plumbago zeylanica L. In spite of its therapeutic anti-cancerous potential, its limited availability from plant sources h...
Nematode-trapping fungus Arthrobotrys oligospora is hungry for iron-chelating agent COQ7 of nematodes [0.03%]
捕线虫真菌阿太罗杆菌吞食线虫辅酶Q7竞争铁元素
Qunfu Wu,Jiao Zhou,Donglou Wang et al.
Qunfu Wu et al.
Iron homeostasis is critical for the survival of almost all organisms, yet its dysregulation is often caused by a synergistic effect of genetic and environmental factors. Previous studies have shown that trapping devices of the predominant ...
Nature meets machine: the AI renaissance in natural product drug discovery [0.03%]
天造机宜：天然产物药物发现的AI复兴
Rajesh Muthuraj,Jaikanth Chandrasekaran
Rajesh Muthuraj
Natural products (NPs) have long served as a cornerstone of drug discovery, yielding landmark therapeutics such as paclitaxel and artemisinin and providing sustained access to biologically relevant chemical space. Despite this legacy, NP-ba...
Advanced delivery of natural bioactive compounds for atopic dermatitis: a review of polymeric conjugates and nanocarriers [0.03%]
用于治疗特应性皮炎的天然生物活性化合物的进阶递送：聚合物缀合物和纳米载体的综述
Jigar Vyas,Nensi Raytthatha,Puja Vyas et al.
Jigar Vyas et al.
Atopic dermatitis (AD) is a persistent, relapsing skin inflammatory disorder characterised by epidermal barrier dysfunction, immune system anomalies, and microbial dysbiosis. Current therapies encompass calcineurin inhibitors, topical corti...